Articles tagged "Autoimmunity"

2017 American Transplant Congress
Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.
T. Brennan,¹ L. Lin,¹ M. Song,¹ F. Feng,¹ Q.-J. Li,² A. Kirk,^1,2 H. Xu.¹
¹Surgery, Duke University, Durham, NC; ²Immunology, Duke University, Durham, NC
Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…
2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
R. Gill,¹ M. Coulombe,¹ T. Kupfer,¹ K. Beard,¹ A. Burrack.²
¹Surgery and Immunology, University of Colorado Denver, Aurora, CO; ²University of Minnesota, Minneapolis, MN
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
2017 American Transplant Congress
IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.
P. Chhabra,¹ C. Wilson,² D. Moore,² K. Brayman.¹
¹Surgery, University of Virginia, Charlottesville, VA; ²Pediatric Endocrinology, Vanderbilt University, Nashville, TN
Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…
2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
A. Arterbery,¹ M. Martinez,³ S. Lobritto,³ Y. Avitzur,² U. Ekong.¹
¹Ped Gastro. and Hep., Yale University, New Haven, CT; ²Gastro., Hep., and Nutr., Hospital for Sick Children, Toronto, ON, Canada; ³Ped. Gastro., Hep., and Nutr., Columbia University, New York, NY
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…
2017 American Transplant Congress
Combining Neural Stem Cell Transplantation with Mixed Hematopoietic Chimerism Promotes Restoration of Self-Tolerance in Established Experimental Autoimmune Encephalomyelitis.
W. Orent, J. Marino, B. Gonzalez Nolasco, J. Paster, A. Harney, D. Sachs, G. Benichou.
Surgery, Massachusetts General Hospital, Boston, MA
Multilineage mixed hematopoietic chimerism induces tolerance to alloantigens in rodents, large animals and kidney-transplanted patients. Here we combined mixed chimerism with neural stem cell (NSC)…
2017 American Transplant Congress
Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.
M. Dieudé,^1,4 J. Turgeon,^1,4 A. Karakeussian-Rimbault,^1,4 L. Pomerleau,¹ A. Robitaille,¹ N. Grandvaux,¹ É. Boilard,^2,4 M.-J. Hébert.^1,3,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal, Montreal, Canada; ²CHU de Québec, Québec, Canada; ³Montreal University, Montreal, QC, Canada; ⁴Canadian National Transplantation Research Program, Edmonton, Canada
Autoantibodies to apoptotic antigens, such as perlecan/LG3, are present pre-transplantation and contribute to organ rejection. We previously showed that during tissue injury, apoptotic endothelial cells…
2017 American Transplant Congress
Non-Human Primate Auto-Immune Responses to Col V, Kα-1Tubulin and Vimentin Are P2X7R Dependent.
J. Sullivan,¹ E. Jankowska-Gan,¹ D. Kaufman,¹ L. Denlinger,² W. Burlingham.¹
¹Surgery, University of Wisconsin, Madison, WI; ²Medicine, University of Wisconsin, Madison, WI
Background: Auto-immune responses to Collagen type V (ColV) have been associated with coronary artery disease and lung or heart transplant rejection in humans and murine…
2017 American Transplant Congress
Predictive Value of Serum Biomarkers of Autoimmunity for Recurrence of IgA Nephropathy After Kidney Transplantation.
N. Maillard,¹ H. Suzuki,² H. Mohey,¹ C. Mariat,¹ J. Novak,³ B. Julian,⁴ F. Berthoux.¹
¹Nephrology, Dialysis and Renal Transplantation, CHU Saint Etienne, Saint Etienne, France; ²Division of Nephrology, Department of Internal Medicine, Juntendo University, Tokyo, Japan; ³Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL; ⁴Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
The recurrence of IgA nephropathy (IgAN) after kidney transplantation is frequent and can cause graft losses. The prediction of the recurrence cannot be performed from…
2017 American Transplant Congress
HLA, ANA, and ANCA Negative Vasculitis in Lung Transplantation Due to Overexpression of α1 Collagen V.
E. Daoud,¹ Y. Butt,¹ F. Torres,² T. Jose.¹
¹Pathology, University of Texas Southwestern Medical Center, Dallas, TX; ²Lung Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX
The mechanism of fibrosing vasculopathy in lung allograft is poorly understood. A 58 year old man received a bilateral lung transplant for interstitial lung disease.…
2017 American Transplant Congress
Recognition of Islet Xenografts In Vivo by Non-Obese Diabetic (NOD) Insulin-Specific CD4 T Cells.
R. Gill, W. Dale, M. Crawford.
Surgery and Immunology, University of Colorado Denver, Aurora, CO
Xenogeneic islet transplantation has been one ongoing goal for treating autoimmune Type 1 diabetes. Autoimmune diabetes involves a T cell response restricted to the host…