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Articles tagged "Autoimmunity"

  • 2015 American Transplant Congress

    Pre-Transplant Anti-LG3 Antibodies Enhance Allograft Dysfunction in Kidney Transplant Recipients With Delayed or Slow Graft Function

    H. Cardinal, M. Hénault-Rondeau, S. Morissette, K. Hamelin, M.-J. Hébert.

    CHUM Research Center, Montreal, Canada.

    Background: We have previously shown that autoantibodies to the LG3 fragment of perlecan enhance vascular damage in a murine model of vascular rejection, particularly when…
  • 2015 American Transplant Congress

    Germinal Centre Autoimmunity Mediates Progression of Allograft Vasculopathy, With Essential Help Provided By T Follicular Cells

    M. Qureshi, R. Motallebzadeh, M. Chhabra, M. Negus, S. Rehakova, E. Bolton, J. Bradley, G. Pettigrew.

    Dept of Surgery, University of Cambridge, Cambridge, United Kingdom.

    Introduction: : In our previous work we have shown that donor CD4 T cells within heart grafts initiate anti-nuclear autoantibody responses. Here we clarify the…
  • 2015 American Transplant Congress

    Donor MHC Independent Rejection of Islet Allografts in Autoimmune NOD Mice

    A. Burrack,1 K. Beard,2 M. Coulombe,2 R. Gill.2

    1Medicine, University of Minnesota, Minneapolis, MN; 2Surgery and Immunology, University of Colorado Denver, Aurora, CO.

    In autoimmune Type 1 diabetes (T1D), pancreatic islet allografts have somewhat limited long-term survival, both in T1D human subjects and in spontaneously diseased non-obese diabetic…
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