Articles tagged "Autoimmunity"

2015 American Transplant Congress
Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus
P. Chhabra,¹ A. Spano,² D. Bowers,¹ M. Wu,² L. Langman,¹ M. Timko,² K. Brayman.¹
¹Department of Surgery, University of Virginia, Charlottesville, VA; ²Department of Biology, University of Virginia, Charlottesville, VA.
Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…
2015 American Transplant Congress
The 20S Proteasome Is Active in Apoptotic Nanovesicles and Controls Anti-LG3 Antibody Production
M. Dieudé,^1,4 C. Bell,^2,4 J. Turgeon,^1,4 D. Beillevaire,^1,4 K. Hamelin,^1,4 S. Qi,^1,4 N. Pallet,^1,4 C. Rondeau,³ D. Gingras,³ M. Desjardins,³ P. Thibault,^2,4 M.-J. Hébert.^1,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Institute for Research in Immunology and Cancer (IRIC), Montreal, QC, Canada; ³Université de Montréal, Montreal, QC, Canada; ⁴Canadian National Transplant Research Program (CNTRP), Montreal, Canada.
Humoral autoreactivity to apoptotic cells and perlecan/LG3, a proteoglycan fragment released by apoptotic cells, predicts poor allograft outcomes in renal transplant patients. How apoptotic cells…
2015 American Transplant Congress
Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin
J. Sullivan,¹ D. Wilkes,² T. Mohanakumar,³ W. Burlingham.¹
¹Surgery, University of Wisconsin, Madison, WI; ²Medicine, Indiana University, Indianapolis, IN; ³Surgery, Washington University, St. Louis, MO.
Background: Injury and repair processes are highly controlled, common occurrences of healthy tissue remodeling. During this process, cellular antigens that are not normally exposed to…