Articles tagged "Area-under-curve (AUC)"

2022 American Transplant Congress
Utility of Four-Point Mycophenolate Mofetil Testing in a Pediatric Kidney Transplant Population
S. Sadiq, P. Brakeman, J. Brennan, E. Black
Pediatric Nephrology, UCSF, San Francisco, CA
*Purpose: While there is randomized, multicenter data in adults that area under the time concentration curve (AUC) measurements for Mycophenolate Mofetil (MMF) can direct dosing…
2022 American Transplant Congress
Post-Kidney Transplant Valacyclovir or Valganciclovir for EBV Prophylaxis: A Randomized Controlled Trial
P. S. Verghese¹, A. Matas², S. Chinnakotla², M. Evans³, H. Balfour Jr⁴
¹Pediatric Nephrology, Northwestern University, Feinberg School of Medicine, Minneapolis, MN, ²Surgery, University of Minnesota Medical School, Minneapolis, MN, ³Biostatistics, University of Minnesota, Minneapolis, MN, ⁴Lab Medicine & Pathology, University of Minnesota, Minneapolis, MN
*Purpose: EBV viremia post-kidney transplant (KTx) has no proven prophylaxis.*Methods: In this randomized, open-label trial [NCT01329185], adult and pediatric recipients were randomly assigned (1:1) to…
2022 American Transplant Congress
Dynamic Risk Prediction of Kidney Graft Failure After Deceased Donor Transplant
D. G. Hu¹, H. Thiessen Philbrook¹, S. Mohan², I. Hall³, M. Doshi⁴, K. F. Kerr⁵, C. R. Parikh¹
¹Johns Hopkins University, Baltimore, MD, ²Columbia University Medical Center, New York, NY, ³University of Utah, Salt Lake City, UT, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Washington, Seattle, WA
*Purpose: Identifying kidney transplant recipients at risk of graft failure allows for early intervention in clinical care. We developed a dynamic risk prediction model based…
2022 American Transplant Congress
Development of a Radiomics-Based Model to Predict Graft Fibrosis in Liver Transplant Recipients: A Pilot Study
F. Qazi Arisar¹, E. Salinas-Miranda², H. Ale Ali², K. Lajkosz³, C. Chen¹, A. Azhie¹, G. M. Healy², D. Deniffel², M. A. Haider², M. Bhat¹
¹Ajmera Transplant Program, University Health Network, Toronto, ON, Canada, ²Lunenfeld Tanenbaum Research Institute, Toronto, ON, Canada, ³Department of Biostatistics, University Health Network, Toronto, ON, Canada
*Purpose: Recurrent fibrosis complicates 40% of Liver transplants (LT), compromising long-term survival. We evaluated the ability of a model combining radiomic features on CT scans…
2022 American Transplant Congress
Meld Score <31 Predicts Spontaneous Recovery in Patients Listed for Liver Transplantation for Alcohol-Associated Hepatitis: A UNOS Database Study
Y. Bekki, G. Im, T. Schiano, S. Florman
Icahn School of Medicine at Mount Sinai, RMTI, New York, NY
*Purpose: Alcohol-associated hepatitis (AH) is the fastest growing indication for liver transplantation (LT) in the U.S. While spontaneous recovery (SR) can occur in patients with…
2022 American Transplant Congress
Tacrolimus and Mycophenolic Acid Therapeutic Exposure Targets in Black and White Kidney Transplant Recipients
K. Tornatore¹, K. Attwood¹, S. Chang¹, A. Gundroo², B. Murray¹
¹Univeristy at Buffalo/SUNY, Buffalo, NY, ²Ohio State Medical Center, Columbus, OH
*Purpose: Tacrolimus and Mycophenolic Acid(MPA), the preferred immunosuppressive regimen for kidney transplant recipients(KTR), exhibit interpatient pharmacokinetic variability which may impact allograft survival in Black and…
2022 American Transplant Congress
Galectin-3 Discriminates Patients with Advanced Cirrhosis and Predicts Post-Liver Transplant Infectious Complications
E. Cervantes-Alvarez¹, M. Vilatobá¹, J. Argemi², N. Limon-de la Rosa¹, O. Mendez-Guerrero¹, C. Huang³, D. Kershenobich¹, R. Bataller⁴, A. Torre⁵, N. Navarro-Alvarez¹
¹Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Liver Unit, Clinica Universidad de Navarra, Hepatology Program, Center for Applied Medical Research, Pamplona, Spain, Pamplona, Spain, ³University of Colorado Anschutz Medical Campus, Denver, CO, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico city, Mexico
*Purpose: An increased demand for liver transplantation (LT) prevails. Galectin-3 is a lectin implicated in inflammation, immunoregulation, and liver fibrosis. In this study we assessed…
2021 American Transplant Congress
Tacrolimus Therapeutic Exposure is Not Consistently Predicted by Target Troughs or CYP3A5 Variants in Stable Renal Transplant Recipients
K. Tornatore¹, K. Attwood², D. Brazeau³, B. Murray⁴
¹Pharmacy Practice, School of Pharmacy; University at Buffalo, Buffalo, NY, ²Biostatistics, School of Public Health; University at Buffalo, Buffalo, NY, ³Pharmacy Practice, School of Pharmacy; Marshall University, Huntington, WV, ⁴Medicine, Erie County Medical Center Corp., Buffalo, NY
*Purpose: Tacrolimus (TAC) immunosuppression requires therapeutic trough monitoring post-transplant due to notable interpatient pharmacokinetic(PK) variability which may be attributed to CYP3A5 polymorphisms. We investigated the…
2021 American Transplant Congress
Exploring the Correlation with Donor Hepatitis C Viral Load and Viral Kinetics in Naïve Kidney Transplantation Recipients
A. Brooks¹, A. Rechnitzer¹, R. Teo¹, D. Y. Goldstein², M. Narlieva², J. P. Rocca¹, M. Ajaimy¹, L. Liriano-Ward¹, Y. Azzi¹, C. Pynadath¹, P. Loarte-Campos¹, E. Akalin¹, M. E. Le¹, H. Yaffe¹, S. Greenstein¹, J. Torabi¹, M. M. Kinkhabwala¹, J. A. Graham¹
¹Montefiore-Einstein Center for Transplantation, Montefiore Medical Center, Bronx, NY, ²Pathology, Montefiore Medical Center, Bronx, NY
*Purpose: The transplantation of Hepatitis C viremic (HCV) kidneys into uninfected recipients was made possible by effective direct acting anti-viral (DAA) therapy. This study aims…
2021 American Transplant Congress
Offer Acceptance Models for Various Endpoints: Initial Response, Final Response, and Conversion from Provisional Yes to Yes
C. Martinez, M. Stuart, A. Placona
United Network for Organ Sharing, Richmond, VA
*Purpose: Offer acceptance models are routinely used for program evaluation and academic research, but the focus tends to be on modelling the final offer response.…

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