Articles tagged "Antigen presentation"

2017 American Transplant Congress
Preventing Alloimmune Rejection in Heart Transplantation by Tolerogenic Dendritic Cells Induced by GDF15 Through Up-Regulation of IDO and Inhibition of the NFκB Signalling Pathway.
Y. Zhang,^1,3 G. Zhang,¹ L. Moszczynski,¹ D. Zhao,^1,3 P. Abulizi,¹ D. Quan,² T. Mele,² K. Liu,³ X. Zheng.^1,2
¹Pathology, University of Western Ontario, London, ON, Canada; ²Surgery, University of Western Ontario, London, ON, Canada; ³Cardiovascular Surgery, Jilin University, Cahngchun, China
Rationale: Growth differentiation factor 15 (GDF15) can inhibit DC maturation, yet whether it can generate tolerogenic dendritic cells (Tol-DCs) to induce immune tolerance in heart…
2017 American Transplant Congress
Imaging Cell Biology in Transplantation.
T. Ueno,¹ M. McGrath,¹ M. Yeung,¹ K. Jung,² Y. Kihara,³ O. Konno,³ Y. Nakamura,³ H. Iwamoto,³ S. Yun,² A. Chandraker.¹
¹Transplantation Research Center, Brighma and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan
Background: Following transplantation, a set of coordinated events occurs within the recipient immune system. Immature dendritic cells (DCs) migrate to sites of inflammation, become activated…
2016 American Transplant Congress
Immunologic Basis for Immunocloaking.
L. Brasile,¹ K. Kizjakina,¹ N. Henry,¹ B. Stubenitsky.²
¹BREONICS Inc., Watervliet, NY; ²Plastic Surgery, University of Utrecht, Utrecht, Netherlands.
A novel organ-specific immunomodifying therapy referred to as immunocloaking (IC) provides protection from early allograft rejection without immunosuppressive drugs. The IC binds to the surfaces…
2016 American Transplant Congress
Activation of Alloreactive T Cells by Allogeneic Exosomes and Cells Cross-Dressed with Allogeneic MHC Molecules.
M. Babiker-Mohamed, J. Marino, P. Crosby, G. Benichou.
Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital & Harvard Medical School, Boston, MA.
Our recent studies have documented the presence of high numbers of recipient antigen presenting cells (APCs) displaying donor MHC molecules (cross-dressed) on their surface after…
2016 American Transplant Congress
Imaging Cell Biology In Vivo with Intravital-Microscopy.
T. Ueno,¹ M. Yeung,¹ N. Igarashi,³ T. Yokoyama,² Y. Kihara,² O. Konno,² Y. Nakamura,² H. Iwamoto,² T. Ikeda,³ M. McGrath,¹ M. Sayegh,¹ A. Chandraker.¹
¹Renal Division, Transplantation Research Center, Brigham and Women's Hospital, Boston, MA; ²Transplant Surgery, Tokyo Medical Univ., Hachioji, Tokyo, Japan; ³Intensive Care Medicine, Tokyo Medical Univ., Hachioji, Tokyo, Japan.
Background: Despite current immunosuppressive therapy, many recipients endure multiple episodes of acute rejection. The interplay between dendritic cells (DCs) and T cells plays a central…
2016 American Transplant Congress
Tissue Priming of Plasmacytoid Dendritic Cells Enhances Their Phagocytosis and Lowers the Threshold for Subsequent Toll-Like Receptor 7/9 Activation.
J. Ruben,¹ G. Garcia-Romo,¹ E. Breman,¹ S. van der Kooij,¹ A. Redeker,² R. Arens,² C. van Kooten.¹
¹Nephrology, Leiden University Medical Centre, Leiden, Netherlands; ²Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.
Plasmacytoid dendritic cells (pDC) have a pivotal role in clearing viral infections, and can regulate tolerance or immunity depending on their activation status. We have…
2016 American Transplant Congress
High PD-L1/CD86 MFI Ratio and IL-10 Secretion Characterize Maturation-Resistant Human Regulatory Dendritic Cells (DCregs) Generated for Clinical Testing in Transplantation.
A. Zahorchak,¹ L. Butterfield,^2,3 C. Macedo,¹ D. Hamm,⁴ D. Metes,^1,3 A. Thomson.^1,3
¹Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh; ²Medicine, University of Pittsburgh, Pittsburgh; ³Immunology, University of Pittsburgh, Pittsgurgh; ⁴Adaptive Biotech, Seattle.
Regulatory dendritic cells (DCregs) have shown considerable potential for safe and effective prolongation of allograft survival in pre-clinical models. In humans, DCregs with purity >84%…
2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
Q. Liu,¹ D. Rojas-Canales,¹ S. Divito,¹ W. Shufesky,¹ A. Larregina,² A. Morelli.¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA; ²Dermatology, University of Pittsburgh, Pittsburgh, PA.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…
2015 American Transplant Congress
Dendritic Cells in Kidney Transplant Biopsies Are Associated With Poor Allograft Survival
I. Batal,¹ S. De Serres,¹ K. Safa,¹ A. Waaga,¹ M. Onozato,² N. Najafian,¹ A. Chandraker.¹
¹Brigham and Women's Hospital/Harvard Medical School, Boston, MA; ²Massachusetts General Hospital/Harvard Medical School, Boston, MA.
Background: Long-term renal allograft survival continues to lag behind the progress seen in short-term transplant outcomes. Dendritic cells (DCs) are the most efficient antigen-presenting cells,…
2015 American Transplant Congress
Proteomic Study Identified a Distinct Panel of Protein Expression in the ATP-Competitive MTOR Kinase Inhibitor Conditioned Dendritic Cells Compared to Rapamycin
T. Ma,¹ Y. Pei,¹ Y. Han,² R. Tao.¹
¹Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; ²Department of Pathology, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China.
Purpose: Dendritic cells (DCs) are key players in both innate and adaptive immunity, as well as in immune tolerance. The mammalian target of rapamycin (mTOR)…