Articles tagged "Antigen presentation"

2020 American Transplant Congress
Strong Engagement of CD137 Suppresses Graft-Versus-Host Disease Through Dendritic Cells
H. Cho¹, J. Lee², B. Kwon³, S. Park⁴, H. Park⁴, K. Yoo², K. Park², J. Kim³, S. Kang³
¹Ulsan University Hospital, Ulsan, Korea, Republic of, ²Nephrology, Ulsan University Hospital, Ulsan, Korea, Republic of, ³Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ⁴Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of
*Purpose: We previously demonstrated that anti-CD137 agonist prevent acute graft-versus-host disease (GVHD) and chronic GVHD in the parent-into-unirradiated F1 acute or chronic GVHD model. Although…
2020 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
K. Abou Daya, D. Zhao, K. Biery, M. Oberbarnscheidt
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
2019 American Transplant Congress
Role of MHC Class II in B Cell and Regulatory T Cell Development
S. K. Germana, Z. Wang, C. A. Huang, L. Kojima, C. G. Rickert, J. F. Markmann, C. LeGuern
Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…
2019 American Transplant Congress
Tolerogenic Nanoparticles Targeting the Aryl Hydrocarbon Receptor
K. Janek¹, J. Fechner¹, S. Gong², Y. Wang², J. Mezrich¹
¹Department of Surgery, Division of Transplantation, University of Wisconsin Hospital and Clinics, Madison, WI, ²Department of Biomedical Engineering, University of Wisconsin Madison, Madison, WI
*Purpose: The aryl hydrocarbon receptor (AHR) has been shown to have a central role in the ability of dendritic cells (DCs) to direct differentiation of…
2019 American Transplant Congress
mTORC2 Restricts mTORC1 Metabolic Function in Dendritic Cells to Limit Their Allostimulatory Activity
H. Dai¹, A. Watson¹, A. Menk², D. Stolz³, G. Delgoffe², A. Thomson¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ²Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, ³Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Mechanistic target of rapamycin complex 2 (TORC2) deficiency in conventional dendritic cells (DC) results in their enhanced pro-inflammatory and T cell allostimulatory activity; however,…
2019 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
K. Abou-Daya, D. Zhao, A. Williams, M. Oberbarnscheidt
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
2019 American Transplant Congress
Clazakizumab Acts on Endothelial Cells to Limit Antibody Mediated Damage
J. Lion¹, K. Poussin¹, E. Chong², D. Glotz³, N. A. Mooney¹
¹Alloimmunité-Autoimmunité-Transplantation, INSERM, Paris, France, ²Vitaeris, Vancouver, BC, Canada, ³Nephrology and Transplantation, Hôpital Saint Louis, Paris, France
*Purpose: Human microvascular endothelial cell expression of HLA class II antigens is strongly increased, both in vitro and in vivo, under inflammatory conditions. HLA class…
2019 American Transplant Congress
Redox State of HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation
R. A. Sosa¹, A. Q. Terry¹, J. Nevarez-Mejia¹, M. Rossetti¹, B. V. Naini¹, V. M. Groysberg¹, F. M. Kaldas², R. W. Busuttil², D. W. Gjertson¹, J. W. Kupiec-Weglinski², E. F. Reed¹
¹Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, ²Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor of acute and chronic graft rejection in orthotopic liver transplantation (OLT) involving a complex interplay between…
2019 American Transplant Congress
The Important Roles of Dendritic Cells in Transplantation
T. Ueno¹, M. M. McGrath¹, M. Y. Yeung¹, S. Cai¹, Y. Ueno¹, T. Yokoyama², Y. Kihara², O. Konno², Y. Nakamura², H. Iwamoto², A. K. Chandraker¹
¹Medicine, Renal Division, Brigham and Women's Hospital, Transplantation Research Center, Boston, MA, ²Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan
*Purpose: The interplay between dendritic cells (DCs) and T cells plays a central role in the process of allograft rejection. Upon antigen exposure, positive costimulatory…
2019 American Transplant Congress
MHC Cross-Dressing in Mixed Hematopoietic Chimerism
B. Gonzalez Nolasco¹, M. Wang¹, W. Orent¹, A. Prunevieille¹, K. Pruner¹, J. O¹, J. Paster¹, J. C. Madsen², G. Benichou¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…