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American Transplant Congress abstracts

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Articles tagged "Antigen presentation"

  • 2020 American Transplant Congress

    The Role of Antigen Presentation in B Regulatory Cell Function

    A. Cuenca1, N. Feeney2, K. Deng2, Q. Fu2, G. Huai2, C. Rickert2, K. Lee2, J. Markmann2

    1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: B regulatory cells (B regs) represent a subset of B cells with non-canonical regulatory function. The majority of effort has been focused on the…
  • 2020 American Transplant Congress

    Intra-Lymph Node Injection of Rapamycin-Alloantigen Microparticles Regulates Dendritic Cell Antigen Presentation

    C. M. Paluskievicz1, Y. Xiong1, W. Piao1, M. Willson-Shirkey1, H. Eppler2, C. M. Jewell2, J. S. Bromberg1

    1U Maryland, Baltimore, MD, 2U Maryland, College Park, MD

    *Purpose: Microparticles (MPs) carrying peptide antigen with immune signals can be directly delivered to lymph nodes (LNs) via intra-LN injections to shape both pro-inflammatory or…
  • 2019 American Transplant Congress

    Role of MHC Class II in B Cell and Regulatory T Cell Development

    S. K. Germana, Z. Wang, C. A. Huang, L. Kojima, C. G. Rickert, J. F. Markmann, C. LeGuern

    Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…
  • 2019 American Transplant Congress

    Tolerogenic Nanoparticles Targeting the Aryl Hydrocarbon Receptor

    K. Janek1, J. Fechner1, S. Gong2, Y. Wang2, J. Mezrich1

    1Department of Surgery, Division of Transplantation, University of Wisconsin Hospital and Clinics, Madison, WI, 2Department of Biomedical Engineering, University of Wisconsin Madison, Madison, WI

    *Purpose: The aryl hydrocarbon receptor (AHR) has been shown to have a central role in the ability of dendritic cells (DCs) to direct differentiation of…
  • 2019 American Transplant Congress

    mTORC2 Restricts mTORC1 Metabolic Function in Dendritic Cells to Limit Their Allostimulatory Activity

    H. Dai1, A. Watson1, A. Menk2, D. Stolz3, G. Delgoffe2, A. Thomson1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, 2Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 3Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Mechanistic target of rapamycin complex 2 (TORC2) deficiency in conventional dendritic cells (DC) results in their enhanced pro-inflammatory and T cell allostimulatory activity; however,…
  • 2019 American Transplant Congress

    Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection

    K. Abou-Daya, D. Zhao, A. Williams, M. Oberbarnscheidt

    Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
  • 2019 American Transplant Congress

    Clazakizumab Acts on Endothelial Cells to Limit Antibody Mediated Damage

    J. Lion1, K. Poussin1, E. Chong2, D. Glotz3, N. A. Mooney1

    1Alloimmunité-Autoimmunité-Transplantation, INSERM, Paris, France, 2Vitaeris, Vancouver, BC, Canada, 3Nephrology and Transplantation, Hôpital Saint Louis, Paris, France

    *Purpose: Human microvascular endothelial cell expression of HLA class II antigens is strongly increased, both in vitro and in vivo, under inflammatory conditions. HLA class…
  • 2019 American Transplant Congress

    Redox State of HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation

    R. A. Sosa1, A. Q. Terry1, J. Nevarez-Mejia1, M. Rossetti1, B. V. Naini1, V. M. Groysberg1, F. M. Kaldas2, R. W. Busuttil2, D. W. Gjertson1, J. W. Kupiec-Weglinski2, E. F. Reed1

    1Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, 2Surgery, UCLA, Los Angeles, CA

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor of acute and chronic graft rejection in orthotopic liver transplantation (OLT) involving a complex interplay between…
  • 2019 American Transplant Congress

    The Important Roles of Dendritic Cells in Transplantation

    T. Ueno1, M. M. McGrath1, M. Y. Yeung1, S. Cai1, Y. Ueno1, T. Yokoyama2, Y. Kihara2, O. Konno2, Y. Nakamura2, H. Iwamoto2, A. K. Chandraker1

    1Medicine, Renal Division, Brigham and Women's Hospital, Transplantation Research Center, Boston, MA, 2Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan

    *Purpose: The interplay between dendritic cells (DCs) and T cells plays a central role in the process of allograft rejection. Upon antigen exposure, positive costimulatory…
  • 2019 American Transplant Congress

    MHC Cross-Dressing in Mixed Hematopoietic Chimerism

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, K. Pruner1, J. O1, J. Paster1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…
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