2017 American Transplant Congress
Risk of Major Bleeding in Solid Organ Transplant Recipients Taking Calcineurin Inhibitors Concomitantly with Direct Oral Anticoagulants Compared to Warfarin.
Pharmacy, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Houston, TX
Purpose: Direct oral anticoagulants (DOAC) and calcineurin inhibitors (CNI) are both substrates of CYP 3A metabolism; therefore, the purpose of this study is to assess…2017 American Transplant Congress
Simultaneous Pancreas-Kidney Transplantation Can Be Safely Done on Dabigatran Therapy.
Due to convenient application, novel oral anticoagulants (NOAC), although not registered for renal failure, are an attractive therapeutic option. They are even more tempting in…2017 American Transplant Congress
Cytotopic Thrombin Inhibition Prior to Cold Ischaemia Attenuates Microvascular Endothelial Ischaemia-Reperfusion Injury.
1Imperial College, London, United Kingdom; 2King's College, London, United Kingdom
Purpose: Microvascular dysfunction post-reperfusion of the ischaemic endothelium manifests as cellular necrosis and enhanced endothelial permeability. Thrombin generation post-reperfusion of the ischaemic endothelium may be…2016 American Transplant Congress
Gene Expression Levels of Advanced Heart Failure Patients in Terms of Coagulation and Its Effect within Multiple Organ Dysfunction Syndrome.
Medicine Cardiology, UCLA, Los Angeles, CA.
MOD is progressive organ failure amongst 2 or more organs. Innate-immunity/inflammation-related coagulopathies can cause disseminated clotting in vasculature leading to organ failure. Purpose is to…2016 American Transplant Congress
Management and Outcomes of Upper Extremity Deep Venous Thrombosis in Heart Transplant Patients.
Upper extremity deep venous thrombosis (UEDVT) is common in post-heart transplant (OHT) patients, likely due to their multiple intravascular catheters and post-surgical state. The clinical…2016 American Transplant Congress
Four-Factor Prothrombin Complex Concentrate as a Strategy to Rapidly Reverse Anticoagulation in Patients Undergoing Cardiac Transplantation: Better Than the Conventional Approach?
PurposeThe purpose of this analysis is to compare outcomes of administering four-factor prothrombin complex concentrate (4F-PCC, Kcentra™) versus standard of care for anticoagulation reversal in…2016 American Transplant Congress
Thrombalexin: Detection & Efficacy of a Membrane-Bound Anti-Thrombin Agent.
1Surgery, Duke University, Durham; 2King's College, London, United Kingdom.
Introduction: Early activation of coagulation may be an important factor in the initiation of innate immunity. Anti-coagulation in the transplant setting is difficult due to…2016 American Transplant Congress
aPC Pretreatment of hEPCR-Expressing PAECs Attenuates Endothelial Cell Damage and Thrombosis.
IntroductionActivated Protein C (aPC), acting primarily through the human endothelial protein C receptor (hEPCR), mediates anti-thrombotic and anti-inflammatory cytoprotective effects in humans. We hypothesized that…2016 American Transplant Congress
Elevated Urinary 11-Dehydrothromboxane B2 Is Associated with Increased Bleeding Risk in Left Ventricular Assist Device Patients.
Purpose: To understand if there is a relationship between aspirin resistance as measured by elevated levels of urinary 11-dehydrothromboxane B2 in patients supported with continuous…2015 American Transplant Congress
Investigating Role of Early VTE Chemoprophylaxis in Kidney Transplant
Objective: Our objective was to determine whether the rate of venothromboembolic events (VTE) varied with early versus delayed prophylaxis administration. Associated bleeding complications were also…
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