2020 American Transplant Congress
Life Supporting Orthotopic Cardiac Xenotransplantation from Genetically Engineered Donor Pigs
*Purpose: Cardiac xenotransplantation (CXTx) might be an alternative treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically-engineered (GE) pig heart is…2020 American Transplant Congress
Human Thrombomodulin Gene Expression on Genetically Modified Donor Pig Hearts is Correlated with Long Term Xenograft Survival
Department of Surgery, University of Maryland Baltimore, Baltimore, MD
*Purpose: Thrombomodulin (TBM) is a coagulation regulatory protein which has shown a protective role against coagulation dysregulation and prevented thrombotic microangiopathy and premature loss of…2020 American Transplant Congress
The Effect of Human Thrombomodulin on Thrombotic Complications in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation
1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…2019 American Transplant Congress
Impact of Prolonged Venous Thromboembolism Prophylaxis on 30-Day Hemostatic Outcomes Following Kidney Transplantation in Patients with Hypercoagulable Risk Factors
Mount Sinai Hospital, New York, NY
*Purpose: A number of hypercoagulable states have been identified through laboratory testing that place patients at greater risk for thrombosis; however, the appropriate management of…2019 American Transplant Congress
A Comparison of the Safety and Efficacy of Apixaban Use in Renal Transplant vs. Non-Renal Transplant Recipients
University of Alabama at Birmingham Hospital, Birmingham, AL
*Purpose: Background: Utilization of direct-acting oral anticoagulants has become a preferred method for chronic anticoagulation in patients with atrial fibrillation (AF) or venous thromboembolism (VTE).…2019 American Transplant Congress
Novel Oral Anticoagulants in Kidney Transplantation: Results from a Pilote Study
Adult Transplantation, Necker Hospital, Paris, France
*Purpose: Oral anticoagulation therapy is frequently prescribed to kidney transplant recipients, for prevention and treatment of thrombotic events. Over the past ten years, novel oral…2019 American Transplant Congress
When to Hold: Apixaban in Renal Transplant Recipients
1Yale New Haven Hospital, New Haven, CT, 2Yale School of Medicine, New Haven, CT
*Purpose: Renal transplant recipients (RTRs) may develop deep venous thrombosis (DVT), pulmonary embolism (PE), or atrial fibrillation requiring treatment with oral anticoagulation. There is limited…2019 American Transplant Congress
Postoperative Atrial Fibrillation in Kidney Transplant Recipients: A Retrospective Study Evaluating Risk of Anticoagulation
*Purpose: Patients with atrial fibrillation (AF) have a higher risk of mortality and adverse cardiovascular events. Pre-operative AF has around 5-9% prevalence and roughly 5%…2019 American Transplant Congress
Effect of Enoxaparin Prophylaxis on Early VTE Post Lung Transplant
*Purpose: Thromboembolic complications are common post-transplant leading to significant morbidity. We instituted early enoxaparin prophylaxis (ppx) in lung transplant recipients (LTR) due to an observed…2019 American Transplant Congress
Safety and Efficacy of Anti Xa Inhibitors Post-Transplant with Concomitant Calcineurin Inhibitors
*Purpose: Despite demonstrated benefits of Anti-Xa Inhibitors (ATIs) in the general population, ATIs have not gained uniform acceptance in SOT due to lack of supportive…
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