Articles tagged "Antibodies"

2021 American Transplant Congress
Non-HLA Antibodies and Eplet Mismatches in Cases with Histological Picture of Antibody-Mediated Rejection with and without HLA Donor-Specific Antibodies
M. Crespo¹, L. Llinás², D. Redondo², C. Butler³, J. Gimeno⁴, M. Pérez-Sáez², A. Buxeda², C. Arias², M. Folgueiras², S. Sanz², N. Valenzuela³, E. E. Reed³, J. Pascual²
¹Nephrology and Kidney Transplantation, Hospital del Mar, Barcelona, Spain, ²Nephrology, Hospital del Mar, Barcelona, Spain, ³UCLA Immunogenetics Center, UCLA, Los Angeles, CA, ⁴Pathology, Hospital del Mar, Barcelona, Spain
*Purpose: Correlation between antibody-mediated rejection (ABMR) and HLA donor-specific antibodies (DSA) is strong but imperfect in kidney transplant (KT) recipients, raising the possibility of other…
2021 American Transplant Congress
Limited Immunogenicity of a Single Dose of Sars-cov-2 Mrna Vaccine in Solid Organ Transplant Recipients
B. Boyarsky, M. Ou, R. Greenberg, A. Teles, W. Werbel, R. Avery, A. Tobian, A. Massie, D. Segev, J. Garonzik Wang
Johns Hopkins, Baltimore, MD
*Purpose: Given substantial challenges with vaccine allocation and evidence for short-term vaccine efficacy after a single dose of SARS-CoV-2 mRNA vaccines in clinical trials, some…
2021 American Transplant Congress
Cellular and Genetic Signatures of Operational Tolerance in Kidney Transplant Recipients Through Single Cell R N A Sequencing Analysis
H. BAE¹, H. Lee², J. Ryu³, B. Chung², E. Oh³
¹Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, ²Department of Internal Medicine, Division of Nephrology, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, Seoul, Korea, Republic of, ³Department of Laboratory Medicine, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of
*Purpose: Patients with operational tolerance do not use immunosuppressants after renal transplantation, but they show stable post-transplant results. We analyzed differently expressed mRNAs and proteins…
2021 American Transplant Congress
Monoclonal Antibodies for Covid-19 in Patients with Solid Organ Transplant Recipients
L. Hasan¹, H. Hardgrave², T. Osborn³, R. Dare¹, L. Burdine⁴, E. Giorgakis⁴, J. Rico¹
¹Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, ²University of Arkansas for Medical Sciences, Little Rock, AR, ³Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, ⁴Transplant surgery, University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: The FDA has issued Emergency Use Authorization (EUA) for monoclonal antibodies for the treatment of mild to moderate COVID-19 in patients at risk for…
2021 American Transplant Congress
Efficacy of MAU868, a Novel BKV Neutralizing Monoclonal Antibody (mAb), for the Treatment of Severe BK Virus Nephropathy (BKVN) After Kidney Transplant
S. C. Jordan¹, N. Ammerman², M. Toyoda³, K. Lim², J. R. Abend⁴, A. Patick⁵, M. R. Hodges⁵, A. Vo², S. J. Kovacs⁶
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, West Hollywood, CA, ²Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Cedars Sinai Medical Ctr, Los Angeles, CA, ⁴Novartis Institutes for BioMedical Research, Virology Research, Emeryville, CA, ⁵Amplyx Pharmaceuticals, San Diego, CA, ⁶Novartis Institutes for BioMedical Research, Translational Medicine, East Hanover, NJ
*Purpose: BKV reactivation leading to nephropathy and allograft loss in kidney transplant (KT) recipients remains a clinical significant concern. No specific or effective anti-BKV therapies…
2021 American Transplant Congress
Immune Response to Covid-19 in Kidney Transplant Waitlist Patients
P. T. Jindra¹, C. M. Foye¹, I. Sharf², A. Rana¹, T. N. Galvan¹, A. Awan¹, C. A. O'Mahony¹, B. V. Murthy¹
¹Baylor College of Medicine, Houston, TX, ²Baylor St. Luke's Medical Center, Houston, TX
*Purpose: The purpose of this study was to determine the effect of SARS-CoV-2 infection on the immune response in Kidney Transplant Waitlist Candidates (KTWC) and…
2021 American Transplant Congress
Quantification of Multiple Isotypes of Anti-SARS-CoV-2 Antibodies in Kidney Transplant Recipients
J. S. Maltzman¹, L. Wang¹, P. Ahearn¹, T. Yalamarti¹, M. Menon², Y. Azzi³, M. Melcher¹, M. Fernandez-Vina¹, R. Bray⁴, H. Gebel⁴, E. Woodle⁵, E. Akalin³, A. Girnita¹, P. Cravedi²
¹Stanford University, Palo Alto, CA, ²Icahn School of Medicine, NYC, NY, ³Einstein School of Medicine, NYC, NY, ⁴Emory University, Atlanta, GA, ⁵University of Cincinnati, Cincinnati, OH
*Purpose: Solid organ transplant recipients are at increased risk of severe outcomes with infection by SARS-CoV-2, the etiologic agent of COVID-19. Antibodies directed against the…
2021 American Transplant Congress
Impaired Antibody Responses to Spike Protein Antigens of Sars-cov-2 in Solid Organ Transplant (sot) Recipients
C. Ashokkumar¹, S. Nadig², V. Rohan², A. Kroemer³, H. Dhani³, S. Rao⁴, R. Sindhi⁵
¹Plexision, pittsburgh, PA, ²Medical University of South Carolina, Charleston, SC, ³MedStar Georgetown Transplant Institute, Georgetown, DC, ⁴DHR Health Institute for Research and Development, Texas, TX, ⁵University of Pittsburgh, Pittsburgh, PA
*Purpose: Chronic immunosuppression can impair antibody responses after natural infection and vaccination in SOT recipients. It is not known whether antibody responses are impaired in…
2021 American Transplant Congress
Seroprevalence of SARS-CoV-2 Antibodies in Transplant Recipients in a Croatian Transplant Center
A. Mrzljak¹, Z. Jurekovic¹, J. Pavicic Saric², L. Antolasic³, L. Milasincic³, I. Tabain³, T. Vilibic Cavlek³
¹Department of Internal Medicine, Merkur University Hospital, Zagreb, Croatia, ²Department of Anesthesiology, Merkur University Hospital, Zagreb, Croatia, ³Department of Microbiology, Croatian Institute of Public Health, Zagreb, Croatia
*Purpose: In Croatia, the first case of coronavirus disease (COVID-19) has been reported on 25 February 2020; however, the COVID-19 seroprevalence in the liver (LTR)…
2021 American Transplant Congress
Extracellular Matrix Injury of Kidney Allografts in Antibody-mediated Rejection
S. Clotet Freixas¹, C. McEvoy¹, I. Batruch², C. Pastrello³, M. Kotlyar³, J. Van¹, M. Arambewela¹, A. Boshart¹, S. Farkona¹, Y. Niu³, Y. Li¹, O. Famure¹, A. Bozovic⁴, V. Kulasingam⁴, P. Chen¹, J. S. Kim¹, E. Chan⁵, S. Moshkelgosha¹, S. A. Rahman⁶, J. Das⁶, T. Martinu¹, S. Juvet¹, I. Jurisica³, A. Chruscinski¹, R. John¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada, ⁶Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Antibody-mediated rejection (AMR) accounts for >50% of kidney graft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in glomeruli…

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