2015 American Transplant Congress
LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection
1Surgery, Emory Transplant Center, Atlanta, GA; 2Surgery, Duke University, Durham, NC.
[Background] Lymphocyte depletion prior to transplantation is beneficial in reducing initial maintenance immunosuppression in transplantation. However, despite its excellent efficacy in controlling T cell mediated…2015 American Transplant Congress
Serum Creatinine Is Most Predictive of Graft Loss in Late Antibody Mediated Rejection
Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.
Development of acute antibody mediated rejection (AMR) is associated with graft loss and can occur both early (< 3 months) and late (> 3 months)…2015 American Transplant Congress
Interstitial Fibrosis Is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy
PURPOSE: Transplant glomerulopathy (TGP) represents chronic antibody-mediated injury in the glomerular capillaries after renal transplantation, and is the main cause of graft failure. TGP is…2015 American Transplant Congress
Impact of Serial Change of Donor Specific Antibodies On the Graft Outcomes After Liver Transplantation
Introduction: This study aimed to investigate the acute rejection rate and graft function after liver transplantation according to pre-transplantation donor specific antibody (DSA) status and…2015 American Transplant Congress
Variables Related to the Development of Donor Specific Antibodies (DSA) Post-Kidney Transplant (KTx): Implications for Late Graft Histology and Survival
1Medicine, Mayo Clinic, Rochester, MN; 2Surgery, Mayo Clinic, Rochester, MN.
Introduction. The incidence of de novo DSA increases post-KTx. DSA is associated to reduced graft survival likely due to chronic antibody mediated rejection (cAMR). However,…2015 American Transplant Congress
BAFF Binding to T Cell-Expressed BAFF-R Promotes Follicular Helper T Cell Proliferation and GC B Cell Responses
Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF) in promoting germinal center (GC) responses in mouse…2015 American Transplant Congress
Isotype Switching of Antibodies to Vimentin Following Transplantation Is Associated With Development of Transplant Glomerulopathy Following Renal Transplantation
Background: Immune responses to tissue restricted self antigens have been proposed to play a role in transplant glomerulopathy (TG). The goal of this study is…2015 American Transplant Congress
ABO Incompatible Simultaneous Liver-Kidney Transplant With Positive Crossmatch. A Case Report
INTRODUCTION: Donor Specific (DS) antibodies and ABO incompatibility remain major immunological barriers in organ transplantation. Clinical evidence suggest the liver can protect a kidney from…2015 American Transplant Congress
Cross-Linking of MHC Class I Induces Unique Transcriptional Profiles Associated With Regulation of Both T and B Cells That Precedes Induction of Allo- and Auto-Immunity Leading to Obliterative Airway Disease
Surgery, Washington Univ Sch of Med, St. Louis, MO.
Background: Incidences of chronic rejection, bronchiolitis obliterans syndrome (BOS), remain a major challenge to lung transplantation and development of allo- and auto-immunity has been proposed…2015 American Transplant Congress
Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function
Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
American Transplant Congress abstracts