ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antibodies"

  • 2015 American Transplant Congress

    Interstitial Fibrosis Is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy

    D. Toki,1 H. Ishida,1 M. Okumi,1 T. Shimizu,1 H. Shirakawa,1 M. Inui,1 K. Omoto,1 K. Unagami,1 T. Kanzawa,1 K. Honda,2 J. Koike,3 K. Tanabe.1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Pathology, Tokyo Women's Medical University, Tokyo, Japan; 3Pathology, Tama Hospital, Kanagawa, Japan.

    PURPOSE: Transplant glomerulopathy (TGP) represents chronic antibody-mediated injury in the glomerular capillaries after renal transplantation, and is the main cause of graft failure. TGP is…
  • 2015 American Transplant Congress

    Impact of Serial Change of Donor Specific Antibodies On the Graft Outcomes After Liver Transplantation

    D. Joo,1,2 J. Lee,3 J. Lee,1,2 J. Lee,1,2 S. Kim,4 D. Han,1,2 M. Ju,1,2 J. Choi,1,2 S. Kim,1,2 M. Kim.1,2

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea; 4Department of Surgery, Wonju Yonsei University College of Medicine, Wonju, Korea.

    Introduction: This study aimed to investigate the acute rejection rate and graft function after liver transplantation according to pre-transplantation donor specific antibody (DSA) status and…
  • 2015 American Transplant Congress

    Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function

    A. Gilbert,1 E. Hall,1 O. Timofeeva,2 M. Awwad,2 M. Grafals,1 P. Weems,1 D. Li,2 S. Rosen-Bronson,2 J. Moore,1 B. Javaid,1 M. Cooper.1

    1Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; 2Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.

    Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
  • 2015 American Transplant Congress

    Outcomes of Kidney Transplantation of ABO- and Crossmatch-Incompatible Recipient-Donor Pairs Entered in Kidney Paired Donation Program

    D. Dadhania, M. Charlton, M. Aull, R. Friedlander, T. Muthukumar, J. Lee, M. Goris, D. Serur, S. Kapur, V. Sharma.

    Transplantation Medicine, Weill Cornell Medical Center, New York, NY.

    Kidney Paired Donation (KPD) enables ABO-incompatible (ABOI) and crossmatch-incompatible (XMI) patients to undergo transplantation using a 'more compatible' donor. Identification of factors that predict early…
  • 2015 American Transplant Congress

    Isotype Switching of Antibodies to Vimentin Following Transplantation Is Associated With Development of Transplant Glomerulopathy Following Renal Transplantation

    M. Gunasekaran,1 T. Maw,3 R. Santos,3 J. Wellen,1 S. Shenoy,1 T. Mohanakumar.1,2

    1Surgery, Washington Univ Sch of Med, St. Louis, MO; 2Pathology & Immunology, Washington Univ Sch of Med, St. Louis, MO; 3Medicine, Washington Univ Sch of Med, St. Louis, MO.

    Background: Immune responses to tissue restricted self antigens have been proposed to play a role in transplant glomerulopathy (TG). The goal of this study is…
  • 2015 American Transplant Congress

    ABO Incompatible Simultaneous Liver-Kidney Transplant With Positive Crossmatch. A Case Report

    T. Heffron,1 C. Kulig,2 P. Gauthier,2 B. Bista,2 S. Dionne,3 T. Pillen,1 M. Asolati.1

    1Surgery, Porter Adventist Hospital, Denver, CO; 2Medicine, Porter Adventist Hospital, Denver, CO; 3LABS, Inc., Centennial, CO.

    INTRODUCTION: Donor Specific (DS) antibodies and ABO incompatibility remain major immunological barriers in organ transplantation. Clinical evidence suggest the liver can protect a kidney from…
  • 2015 American Transplant Congress

    Cross-Linking of MHC Class I Induces Unique Transcriptional Profiles Associated With Regulation of Both T and B Cells That Precedes Induction of Allo- and Auto-Immunity Leading to Obliterative Airway Disease

    D. Nayak, M. Sharma, Z. Xu, A. Gelman, T. Mohanakumar.

    Surgery, Washington Univ Sch of Med, St. Louis, MO.

    Background: Incidences of chronic rejection, bronchiolitis obliterans syndrome (BOS), remain a major challenge to lung transplantation and development of allo- and auto-immunity has been proposed…
  • 2015 American Transplant Congress

    Donor-Specific Alloantibody After Positive Crossmatch Kidney Transplantation With Eculizumab (EC): Correlation With Transplant Glomerulopathy and Graft Failure

    C. Schinstock,1 F. Cosio,1 L. Cornell,1 M. Gandhi,1 M. Everly,2 M. Stegall.1

    1Mayo Clinic, Rochester, MN; 2Paul Terasaki Foundation, Los Angeles, CA.

    Introduction. EC (C5 blockade) reduces the incidence of early clinical acute antibody mediated rejection (AMR) after +XMKTx, but does not prevent chronic AMR. We examined…
  • 2015 American Transplant Congress

    Differential Clinical Outcomes in Kidney Transplant Recipients With De Novo C1q+ and C1q- Donor Specific Antibodies

    M. Ajaimy,1 A. Colovai,2 S. Calp,1 J. Lindower,1 M. Melamed,3 E. Akalin.1

    1Transplantation, Einstein/Montefiore Transplant Center, Bronx; 2Tissue Typing Laboratory, Einstein/Montefiore Transplant Center, Bronx; 3General Nephrology, Einstein/Montefiore Teaching Hospital, Bronx.

    Background: We investigated the prevalence and clinical significance of C1q binding versus non-C1q binding de novo DSA in kidney transplant recipients.Methods: The study group included…
  • 2015 American Transplant Congress

    The Impact of Microcirculation Inflammation in Predicting Treatment Response for Late Onset Antibody Mediated Rejection

    J. Lee,1 J. Lee,1 B. Lim,2 B. Kim,3 M. Ju,1 M. Kim,1 S. Kim,1 Y. Kim,1 H. Jeong,2 K. Park,4 K. Huh.1

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Pathology, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Internal Medicine, Yonsei University Health System, Seoul, Republic of Korea; 4Department of Surgery, CHA Bundang Medical Center, Bundang, Republic of Korea.

    BackgroundThere have been marked advances of immunosuppression. However, management of late onset antibody-mediated rejection (AMR) after 6 months is still challenging. Despite important diagnostic and…
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