Articles tagged "Antibodies"

2022 American Transplant Congress
A Low Immuknow Level but Behold….pAMR1(H+) Rejection
M. W. Weston
Tampa General Hospital, Tampa, FL
*Purpose: PURPOSE: The purpose of this study is to evaluate the mechanism of pAMR1(H+) rejection in heart transplant recipients with low ImmuKnow levels (ATP
2022 American Transplant Congress
Anti-CD80/86 Antibody (RM80/GL-1) Suppressed Murine Donor Specific Antibody Through Anergy CD4⁺T Cells
Y. Yamamoto¹, K. Uchida², K. Iguchi¹, M. Niimi³, M. Uchiyama¹
¹Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan, ²Juntendo University, Tokyo, Japan, ³Department of Surgery, Teikyo University, Tokyo, Japan
*Purpose: The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells may play an important role in alloimmune responses. We investigated…
2022 American Transplant Congress
A Machine Learning Model for Predicting Antibody Response to 2-Dose Sars-cov-2 MRNA Vaccine Series in Transplant Recipients
J. L. Alejo¹, J. Mitchell¹, T. Chiang¹, A. Abedon¹, W. Werbel¹, R. Avery¹, A. Tobian¹, A. Massie¹, J. Garonzik-Wang², D. Segev¹, S. Bae¹
¹JHU, Baltimore, MD, ²U of Wisconsin, Madison, WI
*Purpose: Understanding risk factors for impaired vaccine responses can guide strategies for testing, additional dose recommendations, and vaccine schedules to provide improved protection in solid…
2022 American Transplant Congress
SARS-CoV-2 Infection is Associated with Greater Neutralizing Antibody Response Compared to Three Doses of Mrna-1273 Vaccine in Solid Organ Transplant Recipients
V. H. Ferreira, V. Hall, T. M. Marinelli, M. Ierullo, V. Kulasingam, A. Humar, D. Kumar
University Health Network, Toronto, ON, Canada
*Purpose: Prior studies suggest that two doses of mRNA vaccine in SOTR may result in lower antibody and T-cell responses relative to levels seen following…
2022 American Transplant Congress
Impaired Humoral Response to Second Dose of BNT162b2 Messenger RNA COVID-19 Vaccine in Kidney Transplant Recipients in Japan: Prospective Observational Study
H. Sasaki¹, K. Hasegawa¹, M. Miura², H. Harada¹, D. Takamoto¹, Y. Takada¹, S. Harada¹, H. Tanaka¹
¹Sapporo City General Hospital, Sapporo, Japan, ²Sapporo Hokuyu Hospital, Sapporo, Japan
*Purpose: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has a major impact on solid organ transplant (SOT) recipients, with mortality rate up to 22%. The…
2022 American Transplant Congress
Pre-Vaccine Antibodies Against Seasonal Betacoronaviruses Are Associated with Decreased Antibody Response to SARS-CoV-2 mRNA Vaccination in Solid Organ Transplant Recipients
A. Karaba¹, W. Zhou¹, T. Aytenfisu¹, T. S. Johnston¹, O. Akinde¹, Y. Eby¹, A. Abedon¹, J. Alejo¹, C. Qin¹, J. Garonzik-Wang², S. Klein¹, J. Bailey¹, A. Cox¹, J. Blankson¹, D. Segev¹, A. Tobian¹, W. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: The impact of antigenic imprinting, when immune memory of one antigen influences the response to subsequent similar antigens, on the antibody response in solid…
2022 American Transplant Congress
Comparison of IGG and IGM Type B Cell Receptor-Mediated MTOR Phosphorylation Signal
Y. Matsuda
Division of Transplant Immunology, Division of Transplant Immunology, Tokyo, Japan
*Purpose: IgG and IgM memory B cells (mBCs) corresponding donor-specific antigen are closely involved in the activation of humoral immunity against transplanted grafts. Therefore, it…
2022 American Transplant Congress
Evolution of Cellular and Humoral Immunity During and After a Three Doses-Course of mRNA-1273 COVID-19 Vaccine in Kidney Transplant Recipients
D. Cucchiari¹, N. Egri¹, J. Casals-Urquiza², J. Del Risco-Zevallos¹, D. Rodríguez-Espinosa³, E. Montagud-Marrahi², J. Rovira⁴, M. Ramirez-Bajo⁵, E. Banón-Maneus⁵, P. Ventura-Aguiar², M. Pascal¹, I. Revuelta⁶, B. Bayès², F. Diekmann²
¹Hospital Clínic de Barcelona, Barcelona, Spain, ²Hospital Clinic de Barcelona, Barcelona, Spain, ³Nephrology and Renal Transplantation, Hospital Clinic of Barcelona, Barcelona, Spain, ⁴Laboratori Experimental de Nefrologia i Trasplantament (LENIT), IDIBAPS, Barcelona, Spain, ⁵IDIBAPS, Barcelona, Spain, ⁶Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain
*Purpose: Seroconversion after a 2 doses of mRNA COVID-19 vaccine in kidney transplant recipients (KTR) ranges between 30 and 50% in different series. We previously…
2022 American Transplant Congress
Additional Dose of SARS-CoV-2 Vaccine Increases Neutralization Capacity in Solid Organ Transplant Recipients
Y. Yoo¹, J. Husson², T. Iraguha³, S. Niederhaus⁴, X. Wen⁵, A. Crane⁵, A. Carrier⁵, J. Avruch⁵, A. Ahuja⁶, M. Mathew⁷, S. Dahiya⁸, A. P. Rapoport⁸, D. Atanackovic⁸, K. K. Saharia²
¹Inst of Human Virology, Baltimore, MD, ²Div of Infect Diseases, Univ of Maryland School of Med. and Inst of Human Virology, Baltimore, MD, ³Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD, ⁴Dept of Surgery, Univ of Maryland School of Med., Baltimore, MD, ⁵Dept of Surgery, Univ of Maryland Med. Center, Baltimore, MD, ⁶Dept of Medicine, Univ of Maryland Med. Center, Baltimore, MD, ⁷Div of Infect. Diseases, Univ of Maryland Med. Center, Baltimore, MD, ⁸Dept of Medicine, Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD
*Purpose: Solid organ transplant recipients (SOTR) develop weak antibody responses after SARS-CoV-2 vaccination. Published data on neutralizing activity of plasma, a better measure of protection,…
2022 American Transplant Congress
Incidence of De Novo Donor Specific Antibodies After Early Steroid Withdrawal in Kidney Transplant Recipients
D. Majmundar, S. Karhadkar, A. Diamond, J. Au, C. Ruggia-Check
Temple University Hospital, Philadelphia, PA
*Purpose: Early steroid withdrawal (ESW) regimens may lead to the formation of de novo donor-specific antibodies (dnDSA) post-kidney transplant, which increases the risk of antibody-mediated…

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