Articles tagged "Antibodies"

2016 American Transplant Congress
Outcomes of Second Kidney Transplantation Compared Primary Transplantation According to Donor Specific Antibody.
J. Lee,^1,2 K. Lee,¹ J. Lee,¹ S. Song,¹ J. Lee,¹ S.-K. Kwon,¹ D. Joo,^1,2 K. Huh,^1,2 M. Kim,^1,2 S. Kim,^1,2 Y. Kim.^1,2
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
Background:Re-transplantation is associated with an improved overall survival of patients with a failed renal allograft. Some studies showed the outcomes of retransplantation are than those…
2016 American Transplant Congress
Diversity of Influenza Antibody Repertoire in Transplant Recipients with Natural Influenza Infection.
V. Ferreira, A. Chruscinski, S. Han, A. Humar, D. Kumar.
Multi-Organ Transplant, UHN, Toronto, Canada.
Background: The nature of the immune response to seasonal Influenza A Virus infection has not been well characterized in transplant patients. Antibodies may be directed…
2016 American Transplant Congress
Molecular Diagnosis of Antibody-Mediated Rejection in Routine Formalin-Fixed Paraffin-Embedded Nonhuman Primate Renal Allograft Biopsies.
B. Adam,¹ I. Rosales,² T. Oura,² R. Smith,² A. Cosimi,² T. Kawai,² R. Colvin,² M. Mengel.¹
¹University of Alberta, Edmonton, Canada; ²Harvard Medical School and Massachusetts General Hospital, Boston.
Background: In 2013, the Banff classification proposed molecular testing as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. We analyzed whether…
2016 American Transplant Congress
Prospective Single Antigen Bead Epitope-Based Clustering for Early Detection of Antibody Mediated Rejection.
A. Lichvar, S. Tremblay, P. Brailey, A. Girnita, R. Alloway, E. Woodle.
U of Cincinnati, Cincinnati.
Purpose:Epitope-based groups of HLA single antigen beads (SAB) often demonstrate clustering in patients with donor specific antibodies (DSA). Coordinated Mean Florescent Intensity (MFI) increases of…
2016 American Transplant Congress
Factors Mediating Kidney Rejection in Patients of Simultaneous Liver-Kidney Transplants.
R. Dong, A. Tambur, L. Gallon, J. Levitsky.
Northwestern, Chicago, IL.
BACKGROUND & AIM: Kidney grafts in simultaneous liver-kidney (SLK) recipients are considered to be immunologically protected due to hepatic tolerance, although recent studies have alternatively…
2016 American Transplant Congress
Assessment of Chikungunya IgM Prevalence Among Deceased Organ and Tissue Donors Using Two Enzyme Immunoassay (EIA) Kits.
H. Prince, M. Altrich, M. Nowicki.
Viracor-IBT Laboratories, Los Angeles, CA.
Study Purpose: The emergence of Chikunungya virus (ChikV) infection in the western hemisphere has raised concerns of donor-derived transmission. We assessed the prevalence of recent…
2016 American Transplant Congress
Pathogenic Role of Anti-HLA Antibodies on Endothelial Progenitor Cell Dysfunction of Highly Sensitized Kidney Transplanted Patients.
V. Cantaluppi,¹ S. Dellepiane,² D. Medica,² G. Tognarelli,² M. Quaglia,¹ C. Musetti,¹ A. Airoldi,¹ L. Biancone.²
¹Nephrology, Dialysis and Kidney Transplantation Unit, University of Eastern Piedmont "A. Avogadro", Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Torino, Torino, Italy.
Anti-HLA antibodies (abs) bind to kidney graft endothelial cells inducing complement-mediated injury and humoral rejection. Endothelial Progenitor Cells (EPC) are bone marrow-derived precursors able to…
2016 American Transplant Congress
Membranoproliferative Glomerulonephritis Pattern without Immunoglobulin and Complement Deposition in Renal Allograft Was Related to the Injury of Antibody-Mediated Rejection.
J. Wen, F. Xu, J. Chen, X. Li, M. Zhang, Z. Zhang, Z. Liu.
National Clinical Research Center of Kidney Diseases, Nanjing, China.
Background: Differential diagnosis of Membranoproliferative Glomerulonephritis (MPGN) in renal allograft was difficult because of the confused etiology. Recurrent or de novo MPGN were related to…
2016 American Transplant Congress
The Effect of Tocilizmab Treatment (TCZ-Rx) on Total IgG and Anti-CMV-IgG Levels in HLA-Sensitized (HS) Kidney Transplant Patients.
B.-H. Shin, S. Ge, J. Choi, J. Kahwaji, A. Vo, A. Petrosyan, S. Jordan, M. Toyoda.
Transplant Immunology Lab, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: TCZ has anti-B cell and anti-inflammatory properties. We have reported its successful use for pre-transplant (Tx) desensitization (DES) and treatment of ABMR. We also…
2016 American Transplant Congress
The Impact of Complement Binding Donor Specific Antibodies in the First Year After Heart Transplantation.
J. Patel, M. Kittleson, D. Chang, T. Aintablian, A. Velleca, D. Ramzy, L. Czer, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: The development of donor specific antibodies (DSA) after heart transplant has been associated with poor outcome. We now have the ability to assess the…