Articles tagged "Antibodies"

2016 American Transplant Congress
Tacrolimus as a Tool for Intracellular Assessment of von Willebrand Factor Production by Activated Human Glomerular Endothelial Cells.
S. Béland, P. Vallin, O. Désy, S. De Serres.
Renal Division, University Health Center (CHU) of Quebec, Laval University, Quebec, QC, Canada.
Background: Von Willebrand factor (vWF) is a prothrombotic mediator stored in intracytoplasmic granules within endothelial cells and is released by endothelial exocytosis, leading to microangiopathic…
2016 American Transplant Congress
Elevation of Peripheral IL-6 in Kidney Transplant Recipients with Antibody Mediated Rejection.
N. Wilson, A. Djamali, R. Redfield.
University of Wisconsin, Madison.
Background: Despite current therapy, antibody mediated rejection (AMR) remains a major cause of kidney allograft loss. IL-6 is a known survival factor of antibody secreting…
2016 American Transplant Congress
Designing and Synthesizing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Long Term Heart Allograft Acceptance While Reducing Plasma Cells and Donor Specific Antibodies.
A. Mihali,¹ E. Sula Karreci,¹ A. Kurdi,³ L. Riella,¹ Y. Kawano,³ H. Fan,² P. Singh,² I. Ghobrial,³ C. Nathan,² G. Lin,² J. Azzi.¹
¹Transplantation Research Center, Harvard Medical School, Boston; ²Department of Microbiology and Immunology, Weill Cornell Medicine, NY; ³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston.
Antibody mediated rejection (AMR) is one of the most important barriers to improving long-term transplant outcomes. Traditional therapies for AMR do not deplete the source…
2016 American Transplant Congress
Circulating Angiotensin II Receptor: Possible Marker for Antibody Mediated Tissue Injury?
P. Kimball, F. McDougan, G. Gupta.
Transplant Surgery, VCU Health, Richmond, VA.
Background. Antibody mediated rejection is the leading cause of renal allograft failure. Membrane-bound angiotensin II receptor(AngII) in the renal allograft can be a target of…
2016 American Transplant Congress
A2 Kidneys into B Recipients: Is Postoperative Anti-A1 Titer Monitoring Useful?
A. DeMers, R. Forbes, D. Moore, K. Smith, D. Shaffer.
Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, TN.
Background: Since the introduction of the new Kidney Allocation System in December 2014, our center implemented a protocol for transplanting A2 kidneys into B recipients…
2016 American Transplant Congress
Baseline Donor Specific Antibody (DSA) More Predictive of Chronic Antibody Mediated Rejection (CAMR) Than the Change in DSA Over Time.
D. Mitema,¹ W. Cheungpasitporn,¹ M. Stegall,¹ F. Cosio,¹ M. Gandhi,² C. Schinstock.¹
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Division of Transfusion Medicine, Mayo Clinic, Rochester, MN.
Introduction: Although therapies are available to at least temporarily reduce DSA, the change in DSA naturally post-transplant remains unknown. We aim to study the serial…
2016 American Transplant Congress
Acquired Down-Regulation of B Cell Function Induced by Donor Blood Group Antigens After ABO-Incompatible Kidney Transplantation.
M. Tasaki,¹ K. Saito,¹ Y. Nakagawa,¹ N. Imai,² T. Aoki,³ M. Kamimura,³ K. Takahashi,¹ Y. Tomita.¹
¹Division of Urology, Department of Regenerative & Transplant Medicine, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan; ²Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; ³Division of Transfusion Medicine and Regenerative Medicine Bioscience Medical Center, Niigata University Medical and Dental Hospital, Niigata, Japan.
Background: The long-term of B cell immunobiology against donor blood group antigen has not been elucidated in ABO incompatible kidney transplantation (ABOi KTx).Methods: The antibody…
2016 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies Are Associated with Allograft Loss in Pediatric Renal Transplantation.
M. Pearl,¹ Q. Zhang,² M. Palma Diaz,³ J. Grotts,⁴ J. Brook,⁴ D. Gjertson,² P. Weng,¹ E. Reed,² E. Tsai.¹
¹Pediatrics, University of California-Los Angeles, Los Angeles, CA; ²Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, CA; ³Anatomic & Clinical Pathology, University of California-Los Angeles, Los Angeles, CA; ⁴Biostatistics, University of California-Los Angeles, Los Angeles, CA.
Background: Angiotensin II type 1 receptor antibody (AT1R-Ab) is associated with vascular injury and allograft failure in adult kidney transplantation. Its role in pediatric transplantation…
2016 American Transplant Congress
Positive Lymphocytes Flow Cytometry Crossmatch Due to AT1r Antibodies in Absence of HLA-DSA.
M. Ramirez,¹ D. Kershaw,² Y. Huang,² J. Magee,³ M. Samaniego,² T. Williams,¹ D. Schauss,¹ T. Franks,¹ Y. Kleyman,¹ D. Ramon.¹
¹Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI; ²Department of Internal Medicine, UMICH, Ann Arbor; ³Department of Surgery, UMICH, Ann Arbor.
The angiotensin II type 1 receptor (AT1r) plays a key role in the renin-angiotensin system. Anti-AT1R antibodies (Abs) have been associated with both acute and…
2016 American Transplant Congress
Poor HLA Matching May Reduce the Beneficial Effect of ABOi Pairs Entering the Paired and Pooled Scheme.
M. Willicombe, C. Lawrence, R. Charif, A. McLean, J. Galliford, D. Taube.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
Introduction: Paired/pooled donation (PPD) facilitates transplantation between UK donor-recipient pairs who are either HLA or blood group incompatible, in whom transplantation is either contraindicated or…