2017 American Transplant Congress
Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.
Surgery, Montefiore Medical Center, Bronx, NY
The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…2017 American Transplant Congress
Exploring Differential Antibody Response to Bortezomib in Heart Transplantation.
Northwestern University, Chicago, IL
Twelve heart transplant candidates (2013-2016) received Bortezomib (BTZ) for desensitization. Differential antibody (Ab) response was observed. BTZ cycles consisted of 4 injections of 1.3 mg/m2;…2017 American Transplant Congress
Impact of Antihypertensive (AHT) Choice and Advagraf® Dose on Immunologic Events in Renal Allografts 24 Months Post-Transplantation (Tx).
Renal allograft inflammation may be modulated by ACEi- or ARB-type AHTs (renin-angiotensin system (RAS)-targeting drugs that may inhibit calcineurin) or by optimizing tacrolimus (TAC) exposure.…2017 American Transplant Congress
Belatacept After Kidney Transplantation in Adolescents.
Pediatric Nephrology, Hannover Medical School, Hannover, Germany
Background: Regardless of recipient age at kidney transplantation (KTx), patients are at greatest risk for graft loss in adolescence. This is in part due to…2017 American Transplant Congress
Mycophenolate Dose Reductions Are Not Associated with De Novo Donor-Specific Antibodies.
University of Colorado, Aurora, CO
De novo donor-specific antibodies (dnDSA) are central to the development of antibody-mediated rejection, which is the most important cause of death-censored graft loss. It is…2017 American Transplant Congress
C-C Chemokine Receptor 5 Polymorphisms and Risk of Antibody-Mediated Rejection in Renal Transplantation.
Antibody-mediated rejection (AMR) is the leading cause of graft failure after kidney transplantation. C-C Chemokine receptor 5 (CCR5) plays an important role in immune cell…2017 American Transplant Congress
Post-Transplant Sensitization: Does it Make a Difference in the Development of First-Year Intimal Thickening?
Cedars-Sinai Heart Institute, Los Angeles
Background: The development of donor specific antibody (DSA) after heart transplantation has been reported to be associated with the development of cardiac allograft vasculopathy (CAV).…2017 American Transplant Congress
Clinical Significance of Alloantibodies in Hand Transplantation: Impact on Rejection and Functional Outcome.
Purpose: Although alloantibodies, and donor-specific antibodies (DSA) in particular, are well-known to negatively impact graft survival in human solid organ transplantation, little is known about…2017 American Transplant Congress
Early and Late Antibody Mediated Rejection and Mixed Acute Rejection Are Clinically Distinct and Demonstrate Biologic Differences in Immunodominant Donor Specific Antibody Characteristics.
1U of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati
Early and late antibody mediated rejection (AMR) and mixed acute rejection (MAR) possibly result from fundamentally different immunologic processes. DSA mediates direct injury by complement-dependent…2017 American Transplant Congress
HLA Donor-Specific Antibody (DSA) Negative Antibody-Mediated Rejection (AMR): Incidence, Treatment and Outcomes.
Background: Banff 2013 criteria for the diagnosis of antibody-meditated rejection (AMR) in kidney transplants require the presence of donor-specific antibody (DSA). Clinical significance of histological…
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