ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Antibodies"

  • 2018 American Transplant Congress

    Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease

    M. Sharma, W. Liu, T. Mohanakumar.

    Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.

    Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…
  • 2018 American Transplant Congress

    Early Conversion to a CNI-Free Immunosuppression with SRL after Renal Tx – 10 yr Follow-Up Analysis of a Prospective Multicenter Trial

    J. Andrassy,1 M. Guba,1 A. Habicht,2 M. Fischereder,3 A. Pascher,4 K. Heller,5 B. Banas,6 O. Hakenberg,7 T. Vogel,8 T. Kauke.1

    1Surgery, Ludwig-Maximilans-University, Munich, Germany; 2Transplant, Ludwig-Maximilans-University, Munich, Germany; 3Nephrology, MED IV, Ludwig-Maximilans-University, Munich, Germany; 4Surgery, Charitée University, Berlin, Germany; 5Medicine, University of Erlangen, Erlangen, Germany; 6Internal Medicine II, University of Regensburg, Regensburg, Germany; 7Urology, University of Rostock, Rostock, Germany; 8Surgery, University of Munster, Munster, Germany.

    Introduction: A prospective multicenter trial comparing an early conversion to a CNI-free immunosuppression with SRL, MMF and steroids with a conventional CsA treatment following renal…
  • 2017 American Transplant Congress

    The Ultimate Calculated Panel Reactive Antibody Value Predicts Mortality After Heart Transplantation.

    E. Kransdorf,1 M. Kittleson,1 J. Patel,1 M. Pando,2 L. Czer,1 J. Kobashigawa.1

    1Cedars-Sinai Heart Institute, Los Angeles; 2Mayo Clinic Arizona, Phoenix

    Background: Sensitized heart transplant (HT) candidates are known to be at higher risk for adverse events after transplantation, including a positive crossmatch, rejection, and death.…
  • 2017 American Transplant Congress

    Lower Incidence of DSA-Induced Chronic Antibody-Mediated Rejection in Abo-Incompatible Renal Transplantation.

    M. Okada,1 Y. Watarai,1 K. Iwasaki,2 K. Futamura,1 T. Hiramitsu,1 M. Tsujita,1 N. Goto,1 S. Narumi,1 T. Kobayashi.2

    1Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; 2Transplant Surgery, Aichi Medical University, Nagakute, Japan

    <INTRODUCTION>Current progress in immunosuppressive therapy has successfully controlled ABO-incompatibility in renal transplantation, although donor specific HLA antibody (DSA) is still insurmountable. Our in vitro experiments…
  • 2017 American Transplant Congress

    Steroid Withdrawal and De Novo Donor-Specific HLA Antibodies in Renal Transplant Patients: A Prospective, Randomized, Controlled Study in Parallel Groups. Preliminary Results.

    J. Alonso-Titos,1 P. Ruiz-Esteban,1 E. Palma,1 V. Lopez,1 A. Caballero,2 M. Leon,3 M. Cobos,4 J. Cruzado,5 J. Sellares,6 A. Torres,4 D. Hernandez.1

    1Nephrology, Regional University Hospital and Malaga University, IBIMA, RD16/0009/0006, Malaga, Spain; 2Immunology, Regional University Hospital, Malaga, Spain; 3Pathology, Regional University Hospital, Malaga, Spain; 4Nephrology, Hospital Universitario de Canarias, CIBICAN, University of La Laguna, RD16/0009/0031, Tenerife, Spain; 5Nephrology, IDIBELL, Hospital de Bellvitge, RD16/0009/0003, Barcelona, Spain; 6Nephrology, Hospital Universitari Vall d'Hebron, RD 16/0009/0030, Barcelona, Spain

    Introduction: Steroids represent a mainstay of immunosuppression after kidney transplant (KT). Steroid withdrawal reduces metabolic and cardiovascular complications, but whether it increases the risk of…
  • 2017 American Transplant Congress

    CD4 T Cells and Co-Engagement with Foreign Protein Are Required in Antibody Response to Non-Self Blood Group A-Antigen.

    I. Adam, B. Motyka, L. West.

    Micro & Immunology, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada; Pediatrics, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada; Pediatrics, Surgerey, and Immunology, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada

    Background: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. B-cell tolerance develops to donor A/B-antigen(s) (Ag) after ABOi HTx…
  • 2017 American Transplant Congress

    Effect of Two Anti-CD20 Abs on B Cell Depletion and Reconstitution in Non-Human Primates.

    W. Sun,1 N. O'Neill,1 T. Zhang,1 G. Braileanu,1 K. Reimann,2 R. Pierson,1 A. Azimzadeh.1

    1Dept. of Surgery, University of Maryland, School of Medicine, Baltimore, MD; 2MassBiologics, University of Massachusetts Medical School, Boston, MA

    Background: B lymphocytes play a central role in host immunity, including antibody elaboration and antigen presentation, and B-cell depletion is being explored to modulate alloimmunity.…
  • 2017 American Transplant Congress

    De Novo, Non-Donor Specific HLA Antibodies Are Associated with Inferior Allograft Outcomes After Kidney and Simultaneous Kidney-Pancreas Transplantation.

    S. Hassan,1 G. Lucisano,1 E. Santos,2 D. McKeown,3 D. Goodall,1 A. Gueret-Wardle,1 A. McLean,1 P. Brooks,2 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom; 3Blood Transfusion, Imperial College Healthcare NHS Trust, London, United Kingdom

    Introduction: Donor specific antibodies [DSAs] occurring after transplantation are associated with poorer outcomes. However the significance of non-donor directed HLA antibodies [ndHLAs] after transplantation in…
  • 2017 American Transplant Congress

    Immunodominant Donor Specific Antibody Reduction with Proteasome Inhibitor Based Treatment: Clinical Variability and Implications for Long Term Graft Survival.

    A. Lichvar,1 A. Leino,1 S. Tremblay,1 A. Shields,2 B. Abu Jawdeh,1 B. Hardy,1 M. Anand,1 M. Cuffy,1 M. Cardi,1 R. Alloway,1 E. Woodle.1

    1University of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati

    Proteasome inhibitor (PI) based regimens treat antibody mediated rejection (AMR) at least in part by eliminating donor specific antibody (DSA). iDSA response to PI-based therapy…
  • 2017 American Transplant Congress

    Regulatory T Cells Inhibit Plasmablast Formation and IgG Production by Tempering T Follicular Helper Cell Function.

    P. Fadakar, C. Macedo, M. Yamada, K. Hadi, D. Metes.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA

    Background: Donor-specific antibodies (DSA) are an important biomarker for acute rejection, transplant glomerulopathy and late allograft failure in kidney transplantation. Few studies have characterized the…
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