2018 American Transplant Congress
Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…2018 American Transplant Congress
Early Conversion to a CNI-Free Immunosuppression with SRL after Renal Tx – 10 yr Follow-Up Analysis of a Prospective Multicenter Trial
Introduction: A prospective multicenter trial comparing an early conversion to a CNI-free immunosuppression with SRL, MMF and steroids with a conventional CsA treatment following renal…2017 American Transplant Congress
The Ultimate Calculated Panel Reactive Antibody Value Predicts Mortality After Heart Transplantation.
1Cedars-Sinai Heart Institute, Los Angeles; 2Mayo Clinic Arizona, Phoenix
Background: Sensitized heart transplant (HT) candidates are known to be at higher risk for adverse events after transplantation, including a positive crossmatch, rejection, and death.…2017 American Transplant Congress
Lower Incidence of DSA-Induced Chronic Antibody-Mediated Rejection in Abo-Incompatible Renal Transplantation.
<INTRODUCTION>Current progress in immunosuppressive therapy has successfully controlled ABO-incompatibility in renal transplantation, although donor specific HLA antibody (DSA) is still insurmountable. Our in vitro experiments…2017 American Transplant Congress
Steroid Withdrawal and De Novo Donor-Specific HLA Antibodies in Renal Transplant Patients: A Prospective, Randomized, Controlled Study in Parallel Groups. Preliminary Results.
Introduction: Steroids represent a mainstay of immunosuppression after kidney transplant (KT). Steroid withdrawal reduces metabolic and cardiovascular complications, but whether it increases the risk of…2017 American Transplant Congress
CD4 T Cells and Co-Engagement with Foreign Protein Are Required in Antibody Response to Non-Self Blood Group A-Antigen.
Background: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. B-cell tolerance develops to donor A/B-antigen(s) (Ag) after ABOi HTx…2017 American Transplant Congress
Effect of Two Anti-CD20 Abs on B Cell Depletion and Reconstitution in Non-Human Primates.
Background: B lymphocytes play a central role in host immunity, including antibody elaboration and antigen presentation, and B-cell depletion is being explored to modulate alloimmunity.…2017 American Transplant Congress
De Novo, Non-Donor Specific HLA Antibodies Are Associated with Inferior Allograft Outcomes After Kidney and Simultaneous Kidney-Pancreas Transplantation.
Introduction: Donor specific antibodies [DSAs] occurring after transplantation are associated with poorer outcomes. However the significance of non-donor directed HLA antibodies [ndHLAs] after transplantation in…2017 American Transplant Congress
Immunodominant Donor Specific Antibody Reduction with Proteasome Inhibitor Based Treatment: Clinical Variability and Implications for Long Term Graft Survival.
1University of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati
Proteasome inhibitor (PI) based regimens treat antibody mediated rejection (AMR) at least in part by eliminating donor specific antibody (DSA). iDSA response to PI-based therapy…2017 American Transplant Congress
Regulatory T Cells Inhibit Plasmablast Formation and IgG Production by Tempering T Follicular Helper Cell Function.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
Background: Donor-specific antibodies (DSA) are an important biomarker for acute rejection, transplant glomerulopathy and late allograft failure in kidney transplantation. Few studies have characterized the…
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