2018 American Transplant Congress
Late Donor-Specific Antibody (Especially Class II) Development is Associated with an Increased Risk for Cardiac Allograft Vasculopathy
Cedars Sinai Medical Center, Los Angeles.
Purpose: Development of donor-specific antibodies (DSA) following heart transplantation (HTx) impacts rejection, cardiac allograft vasculopathy (CAV), and survival. In addition, the timing of Ab development…2018 American Transplant Congress
Evaluation of Immunosuppression and Infection after Desensitization in Lung Transplantation
University of Maryland Medical Center, Baltimore.
Purpose: To reduce waitlist time for sensitized lung transplant recipients (LTR), our center used peri-operative desensitization for LTR with a positive virtual crossmatch (P-VXM). We…2017 American Transplant Congress
Longitudinal Study of Donor Specific Antibodies in a Pediatric Kidney Transplant Population; Response to Optimization of Anti-Proliferative Therapy.
Children's Hospital Colorado, Aurora, CO
In 2015 we implemented surveillance donor-specific antibody (DSA) monitoring in our pediatric kidney transplant recipients (pKTR); we found that in stable pKTRs (i.e. no changes…2017 American Transplant Congress
Antibodies Specific for HLA Class I and Lung Associated Self-Antigens, Kα1Tubulin and Collagen V, Induces Exosomes Following In Vitro Binding to Human Airway Epithelial Cells.
Norton Thoracic Institute, St. Joseph's Hospital and Med Center, Phoenix
Background: It is generally accepted that antibody (Ab) binding to its specific antigen, in addition to activating complement pathway, can induce intracellular signals leading to…2017 American Transplant Congress
Poor Prediction of Rejection and Kidney Survival by Donor-Specific-Antibodies Characterization.
Kidney transplant recipients with DSA have a greater likelihood of developing antibody-mediated rejection (ABMR) and kidney allograft loss. The aim of this study was to…2017 American Transplant Congress
Microvascular Inflammation at 4 Months Posttransplant Is Associated with Transplant Glomerulopathy at One and Two Years Independent of Rejection and Donor Specific Antibodies.
Aim: Study factors that are associated with transplant glomerulopathy (TG) in flowcytometric crossmatch negative kidney transplant recipients with no desensitization.Methods:Single center retrospective analysis of characteristics…2017 American Transplant Congress
Primary Graft Dysfunction Post Heart Transplantation: Is There Greater Risk for De Novo Donor-Specific Antibody Development?
Cedars-Sinai Heart Institute, Los Angeles
Background: Primary graft dysfunction (PGD) may occur in up to 30% of heart transplant recipients and has been associated with increased mortality. The development of…2017 American Transplant Congress
HLA-C Mismatching and Humoral Alloimmune Responses in Pediatric Kidney Recipients with Subclinical Vascular Injury.
University of Alabama at Birmingham, Birmingham, AL
Background: Antibodies to mismatched donor HLA antigens (DSA) have been associated with poor long-term outcomes in adult kidney recipients. We recently demonstrated a high prevalence…2017 American Transplant Congress
A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.
PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…2017 American Transplant Congress
DSA Presence Does Not Affect Renal Histology and Clinical Outcome in Chronic Active Antibody Mediated Rejection.
1Erasmus MC, Rotterdam, Netherlands; 2Leiden UMC, Leiden, Netherlands
Introduction. Chronic active antibody mediated rejection (caABMR) is a major cause of long term renal allograft dysfunction. It is defined by the presence of microvascular…
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