2018 American Transplant Congress
Measles and Varicella Vaccination Status and Evidence of Immunity during Solid Organ Pre-Transplantation Evaluation
Pediatric Infectious Diseases, Cleveland Clinic, Cleveland, OH.
Background: Ensuring complete vaccination is important during a pre-transplant evaluation (PTE), especially for live viral vaccines which are generally contraindicated after transplant. After one dose…2018 American Transplant Congress
Graft Immunocomplex Capture Fluorescence Analysis Can Detect Intra-Graft Anti-Blood Group A/B Antibodies
Background: Graft immunocomplex capture fluorescence analysis (ICFA) is an attractive method to detect intra-graft donor-specific anti-HLA antibodies (HLA-DSA). In ABO incompatible (ABOi) transplantation, anti-A/B antibodies…2017 American Transplant Congress
A Prospective Iterative Trial of Carfizomib-Based Desensitization Trial: Initial Comparative Observations.
1U of Cincinnati, Cincinnati; 2Christ Hospital, Cincinnati
Carfilzomib (CFZ) is a 2nd generation proteasome inhibitor different form bortezomib in that it irreversibly disables 20s and 26s proteasomes.Results from the first 2 phases…2017 American Transplant Congress
Improved Outcome of Kidney Transplants by Donor Recipient Matching Based on Predicted Indirectly Recognizable HLA Epitopes.
Introduction: De novo donor-specific HLA antibodies (dnDSA) are recognized as a risk factor for graft loss. Determinants of DSA specificity are generated via the indirect…2017 American Transplant Congress
Percentage of CD19+ B Cells as a Predictor of Acute Antibody-Mediated Rejection After Administration of Rituximab in ABO-Incompatible Kidney Transplantation.
Urology, Hokkaido University, Sapporo, Japan
[Introduction] Administration of rituximab to ABO-incompatible kidney transplant (ABOi-KTx) recipients is recognized as effective and safe. A single dose of 375 mg/m2 rituximab is generally…2017 American Transplant Congress
Preformed HLA Donor-Specific Antibodies Disappearance After Kidney Transplantation: Significance and Comparison with Persistent DSA.
The presence of donor-specific antibodies (DSA) increase the risk of antibody-mediated rejection (ABMR) and graft failure in kidney transplant recipients (KTR). We aimed to analyze…2017 American Transplant Congress
A-Antigen (Ag)-Specific Tolerance Following A-Ag Administration to Infant Mice.
Purpose: In contrast to adults, ABO-incompatible heart transplantation (ABOi HTx) can safely be performed in infants due to absent/low levels of anti-A/B antibodies (Ab). Tolerance…2017 American Transplant Congress
Antibody Mapping by Protein Microarray Revealed a Unique Repertoire in Lung Transplant Recipients That Developed Chronic Lung Allograft Dysfunction.
Background: Development of chronic lung allograft dysfunction (CLAD) limits long-term success from lung transplantation (LTx). Elicitation of de novo antibody (Ab) to mismatched donor HLA…2017 American Transplant Congress
Early Results of Immune Profile Emerging Before Detection of De Novo Humoral Alloimmunity in Kidney Transplant Recipients.
The purpose of this IRB-approved study is to determine if there is a potential role for CD8+ T cell-mediated suppression of donor specific alloantibody (DSA)…2017 American Transplant Congress
Outcome of ABO-Incompatible Kidney Transplantation After Stratified Desensitization.
Background. Plasmapheresis for antibody removal and rituximab for antibody production suppression are performed for desensitization against ABO-incompatible kidney transplantation. We evaluated clinical outcome for optimizing…
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