2018 American Transplant Congress
Rituximab Interference in B-Cell Crossmatch: A Problem Solved
Background: Rituximab is commonly prescribed in ABO- or HLA-incompatible kidney transplantation. When used before transplant it interferes with B lymphocyte complement-dependent crossmatch (CDC CM) or…2018 American Transplant Congress
Contemporary Desensitization with Low Dose Rituximab Ensures Kidney Transplant Outcome beyond ABO Blood Type Incompatibility:A Comparison between past Regimens in Single Institute
Kidney Transplant Surgery and Urology, Sapporo City General Hospital, Sapporo, Japan.
INTRODUCTION: An ABO incompatible kidney transplant (ABOiKT) requires desensitization (DS). The ways of DS have been changed chronologically and the outcome could have been subsequently…2018 American Transplant Congress
Reassessment of Virtual Crossmatch: The Clinical Meaning of Cell-Based Actual Crossmatch for Kidney Transplantation
Background: Due to the high sensitivity and specificity of Luminex technique, the Luminex single antigen beads (LSAB) assays are widely used in detecting the HLA…2018 American Transplant Congress
Equivalent Clinical Outcomes and Stable Post-Operative Anti-A IgG Titers in A2 to B Renal Transplant Recipients Compared to Matched B to B Cohort
With the longest wait times and lowest rate of transplantation, ABO type B renal transplant candidates are at a disadvantage when compared to their type…2018 American Transplant Congress
B Cell Immune Repertoire Sequencing Identifies Pre-Transplant Rejection Risk
1Surgery, UCSF, SF; 2ICHS, UCSF, SF; 3Pathology, Stanford, Stanford.
Background: The diversity of the B cell immune repertoire may drive humoral injury and rejection in organ transplantation (tx).Methods: We utilized advances in next-generation sequencing…2018 American Transplant Congress
IgM HLA DSAs Do Not Alter the Outcomes of Renal Allograft Rejection
Introduction: whilst IgG HLA DSAs are associated with renal allograft rejection and graft loss, the role of IgM HLA DSAs is controversial. We investigate the…2018 American Transplant Congress
Impact of Vitamin D Status on Immune-Mediated Graft Function Following Kidney Transplantation
Ubiquitous expression of vitamin D receptors on antigen-presenting cells has sparked interest into its immunomodulatory effects. While previous literature has described the effect of vitamin…2018 American Transplant Congress
Two Similar Risk Models Identify Different Patients for Graft Loss: Implications for Clinical Trials in DSA+ Kidney Transplant Recipients
William J von Liebig Transplant Center, Mayo Clinic, Rochester.
Introduction. Kidney Transplant Recipients (KTx) with donor-specific alloantibody (DSA) at transplantation have increased death-censored graft failure (DCGF) due to chronic antibody mediated rejection (cABMR), but…2018 American Transplant Congress
Assessment of Donor Specific Anti-HLA Antibodies throughout SLK Transplantation
Simultaneous Liver-Kidney transplantation provides a mechanism to protect the transplanted kidney from recognition by the recipient's immune response compared to solitary kidney transplant alone. High…2018 American Transplant Congress
Mitochondrial Autophagy Proteins Bnip3 and Nix Maintain Memory B Cell Survival
Despite the use of immunosuppressive drugs, allograft rejection remains a major hurdle for the long-term success of organ transplants. Burgeoning evidence implicates memory B cells…
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