Date: Saturday, June 2, 2018
Session Name: Poster Session A: Kidney: Cardiovascular and Metabolic
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
Ubiquitous expression of vitamin D receptors on antigen-presenting cells has sparked interest into its immunomodulatory effects. While previous literature has described the effect of vitamin D on graft function, the impact on immunologic outcomes has yet to be explored. The purpose of this study was to evaluate an association between vitamin D levels and immune-mediated graft function. We performed a single-center review of 125 kidney transplant recipients (KTRs) from 2014-2016. All KTRs were discharged on ergocalciferol 50,000 units weekly. KTRs were categorized as deficient (<20 ng/mL), insufficient (20-30 ng/mL), or sufficient (>30 ng/mL). Immune-mediated graft function was measured by a composite of immunologic graft loss, acute rejection, and de novo donor specific antibodies (dnDSAs) at 1 year post-transplant. Baseline demographics were similar, with the exception of more males in the sufficient group (Table 1). Overall rates of rejection and dnDSAs were 14% and 17% respectively, with no graft losses. Rates did not differ significantly between groups (Table 2). Compared to KTRs with sufficient 25(OH)D levels at 1 month, insufficient (OR=1.3, 95%CI 0.4 to 3.7, p=0.68) and deficient (OR=1.1, 95%CI 0.4 to 3.2, p=0.84) 25(OH)D levels were not associated with the composite outcome at 1 year post-transplant using unadjusted logistic regression. Our preliminary data suggests no correlation between vitamin D levels and graft outcomes at 1 year post-transplant, though larger studies are warranted.
(n = 53)
(n = 41)
(n = 31)
|Male||57% (30)||54% (22)||71% (22)|
|Deceased||64% (34)||32% (13)||58% (18)|
|White||34% (18)||46% (19)||29% (9)|
|African American||25% (13)||20% (8)||35% (11)|
|Immunologic Graft Outcomes||Deficient
(n = 53)
(n = 41)
(n = 31)
|Primary composite endpoint||25% (13)||27% (11)||23% (7)|
|Immunologic graft loss||0||0||0|
|Biopsy-proven acute rejection||11% (6)||12% (5)||19% (6)|
|Development ofdnDSAs||17% (9)||17% (7)||16% (5)|
CITATION INFORMATION: Pham C., Pierce B., Bapat S., Kuten S., Moore L., Gaber A. Impact of Vitamin D Status on Immune-Mediated Graft Function Following Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Pham C, Pierce B, Bapat S, Kuten S, Moore L, Gaber A. Impact of Vitamin D Status on Immune-Mediated Graft Function Following Kidney Transplantation [abstract]. https://atcmeetingabstracts.com/abstract/impact-of-vitamin-d-status-on-immune-mediated-graft-function-following-kidney-transplantation/. Accessed October 25, 2020.
« Back to 2018 American Transplant Congress