Articles tagged "Antibodies"

2020 American Transplant Congress
Passenger Lymphocyte Syndrome Due to Anti-Rh(D) Reactivity after Kidney Transplantation: A Case Report
S. Nemr¹, S. Bani Hani¹, E. Klohe², C. Gresens³, S. Desmond¹, O. Ojogho¹
¹Kidney and Pancreas Transplant Program, Providence Sacred Heart Medical Center & Children's Hospital, Spokane, WA, ²HLA Laboratory, Inland Northwest Blood Center, Spokane, WA, ³Inland Northwest Blood Center, Spokane, WA
*Purpose: PLS can occur soon after solid organ transplantation when donor-derived antibodies against recipient red cell antigens are produced and lead to hemolysis. The anemia…
2020 American Transplant Congress
High-Risk Antibodies Pre-Transplant Impacts Outcome after Heart Transplantation
J. A. Kobashigawa, M. Kittleson, J. Patel, D. Chang, E. Kransdorf, D. Geft, K. Nishihara, A. Shen, L. Czer, F. Esmailian
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Pre-transplant circulating antibodies (Abs) are known to impact outcome after heart transplantation (HTx). Abs can now be detected by single-bead assay but also characterized…
2020 American Transplant Congress
Navigating Through IgM Antibodies in Deceased Donor Kidney Transplants from A2/A2B Donors to B Recipients
M. Kueht, A. Gamilla-Crudo, S. Hussain, R. Kulkarni, J. Fair, H. Stevenson-Lerner, M. Mujtaba
University of Texas Medical Branch, Galveston, TX
*Purpose: Multiple studies have shown acceptable deceased donor transplant (DDT) outcomes from A2 and A2B donors into B recipients; however, concerns remain for acute rejection…
2020 American Transplant Congress
Clinical Relevance of Immunoglobulin M Deposition in Peritubular Capillaries in ABO-Incompatible Kidney Transplantation
D. Toki¹, M. Okumi², K. Unagami², Y. Kakuta², H. Ishida², K. Yamashita¹, H. Tachibana¹, A. Hayashida¹, T. Horiuchi¹, Y. Ishiyama¹, K. Honda³, T. Kondo¹, K. Tanabe²
¹Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan, ²Urology, Tokyo Women's Medical University, Tokyo, Japan, ³Anatomy, Showa University, Tokyo, Japan
*Purpose: Immunoglobulin M (IgM) deposition in peritubular capillaries (PTCs) is rarely identified in renal allograft biopsies of ABO-compatible kidney transplantation. In ABO-incompatible kidney transplantation (ABOI-KTx)…
2020 American Transplant Congress
Pre-Transplant Detection of Anti-at1r Antibodies and Pediatric Kidney Transplantation Outcomes
K. Hitchman¹, C. Usenko², R. Hinojosa¹, D. Ranch¹
¹UT Health San Antonio, San Antonio, TX, ²University Health System, San Antonio, TX
*Purpose: Describe correlations between pre-transplant (PreTXP) presence of anti-angiotensin II receptor type 1 antibodies (AT1R Ab) and post-transplant (PostTXP) outcomes in a pediatric kidney transplant…
2020 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
V. Gorbacheva, R. Fan, S. Miyairi, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…
2020 American Transplant Congress
Peripheral Blood RNA Sequencing Unravels a Differential Role of Coding and Non-Coding Genes by Types of Kidney Allograft Rejection
S. Sur¹, S. Pineda¹, T. Sigdel¹, M. Sirota¹, O. Bestard², M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Laboratory of Experimental Nephrology and Transplantation, Barcelona, Spain
*Purpose: Peripheral blood molecular patterns characterizing the different effector immune pathways driving kidney allograft rejection remain to be fully completely elucidated, to more fully type…
2020 American Transplant Congress
Carfilzomib-Based Desensitization: Effects on HLA, Non-HLA, Auto, and Antiviral Antibodies
S. Tremblay¹, E. Portwood¹, A. R. Shields², R. R. Alloway¹, P. A. Brailey¹, E. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²U Cincinnati, Christ Hospital, Cincinnati, OH
*Purpose: An important question in plasma cell (PC) therapies is the specificity of therapy for PC populations. It is known that plasmablast populations are exquisitely…
2020 American Transplant Congress
dd-cfDNA as a Risk Factor for Initiating De-Novo Donor Specific Antibodies in Heart Transplantation
E. DePasquale¹, J. Kobashigawa², S. Pinney³, K. Khush⁴
¹Keck Hospital of USC, Los Angeles, CA, ²Cedars-Sinai, Beverly Hills, CA, ³Mount Sinai Health System, New York, NY, ⁴Stanford University, Stanford, CA
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury of the cardiac allograft, may contribute to sensitization of the recipients’ immune system. Antigenic presentation…
2020 American Transplant Congress
Late Intra-Patient Tacrolimus Variability Predicts De Novo Donor-Specific Antibody and Graft Loss
J. Lee¹, E. Kim¹, S. Yang², S. Kim¹, H. Choi³, B. Kim⁴, M. Ju⁵, M. Kim², S. Kim², Y. Kim², K. Huh²
¹Department of Transplantation Surgery, Severance Hospital, Seoul, Korea, Republic of, ²Department of Transplantation Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Internal Medicine, Severance Hospital, Seoul, Korea, Republic of, ⁵Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of
*Purpose: Intra-patient variability (IPV) of tacrolimus level has been associated with poor outcomes after kidney transplantation. However, these findings were limited mainly to measurements early…