Articles tagged "Antibodies"

2021 American Transplant Congress
Anti-CD272 Antibody (6B2) Generated Foxp3⁺Regulatory T Cells and Suppressed Donor Specific Antibody in Murine Cardiac Transplant Model
Y. Yamamoto¹, M. Uchiyama², K. Uchida³, H. Yagita³, M. Niimi¹
¹Department of Surgery, Teikyo University, Tokyo, Japan, ²Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan, ³Juntendo University, Tokyo, Japan
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
2021 American Transplant Congress
Comparing Bortezomib Protocol versus IVIG/Rituximab in the Treatment of Antibody Mediated Rejection (AMR) in Kidney Transplantation
V. M. Lowery¹, A. Centeno¹, T. Harrison¹, P. Cabrera¹, A. Mattiazzi²
¹Pharmacy, Jackson Memorial Hospital/Miami Transplant Institute, Miami, FL, ²Nephrology & Hypertension, Miami Transplant Institute, Jackson Memorial Hospital/Miami Transplant Institute, Miami, FL
*Purpose: To compare outcomes of historical treatment of AMR [PLEX + IVIG + Rituximab] with addition of bortezomib, along with characterizing safety parameters aimed at…
2021 American Transplant Congress
Prevalence and Dynamics of SARS-COV-2 IgG in Kidney Transplant Recipients
Y. Al Azzi, P. Loarte, C. Pynadath, O. Alani, L. Liriano-Ward, M. Ajaimy, R. Bartash, J. Graham, M. Le, H. Yaffe, S. Greenstein, J. Rocca, M. Kinkhabwala, E. Akalin
Montefiore Medical Center, New York, NY
*Purpose: We aimed to investigate the prevalence and dynamics of SARS-CoV-2 IgG in kidney transplant recipients in the Bronx, New York, one of the epicenters…
2021 American Transplant Congress
The Co-Occurrence of Newly Developed HLA Donor Specific Antibody and Positive C3d/C4d Profiles Along with Immune Therapy Non-Compliance in Pediatric Heart Transplant Recipients is a High Risk Indicator for Patient Mortality
A. Zhang, C. Nasman, J. Allen, Y. Sun, D. Thomas, R. Rodriguez, C. Tan, G. Boyle
Cleveland Clinic Foundation Transplant Center, Cleveland, OH
*Purpose: Increasing evidence has implicated the deleterious effect of HLA donor specific antibody (DSA) in pediatric heart transplantation (PHTx). However, there are still insufficient research…
2021 American Transplant Congress
Membrane versus Centrifuge‑Based Therapeutic Plasma Exchange to Treat Antibody-Mediated Rejection in Kidney Transplantation
P. Maggiani¹, J. C. Ramirez Valdestino¹, J. H. Cano Cervantes¹, O. D. Díaz Avedaño¹, G. García Castillo¹, M. C. Oseguera Vizcaíno², M. A. Covarrubias², M. Matías Carmona¹, D. F. Ovando Morga¹, G. Ramirez Ramirez¹, V. D. Lebrija Córdoba¹, S. Hernandez Estrada¹
¹Transplantation, Centro Medico Nacional 20 de Noviembre, Mexico City, Mexico, ²Transplantation, Hospital Civil Fray Antonio Alcalde, Guadalajara, Mexico
*Purpose: Therapeutic plasma exchange (TPE) is either performed using a highly permeable filter with standard multifunctional renal replacement equipment (mTPE) or a centrifugation device (cTPE).…
2021 American Transplant Congress
Desensitization Using Costimulatory Blockade and Bortezomib to Prevent DSA Formation and Rejection in Reconstructive Transplantation
B. Oh¹, F. Messner², Y. Guo¹, G. Brandacher¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Visceral, Transplant and Thoracic Surgery, University of Innsbruck, Innsbruck, Austria
*Purpose: Sensitization in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection constitute some of the greatest risk factors for allograft rejection and long-term graft…
2021 American Transplant Congress
Anti-pig IgE and IgA Antibodies in Sera of (i) Naïve Primates and (ii) Non-human Primates Sensitized to Pig Xenografts
H. Hara, Q. Li, H. Iwase, T. Yamamoto, D. Ayares, D. K. Cooper
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Anti-pig IgM and IgG antibodies in primates play an important role in xenograft rejection. The possible roles of anti-pig IgE and IgA have not…
2021 American Transplant Congress
Donor Derived Cell Free Dna: Teasing Out the Optimal Threshold for Antibody Mediated Rejection
M. Mattu¹, H. Murad¹, M. Merzkani¹, A. Malone¹, R. Delos Santos¹, M. Wang², B. Wang², S. Chang², T. Alhamad¹
¹Department of Medicine, Washington University in St Louis, St Louis, MO, ²Washington University in St Louis, St Louis, MO
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) assay is a putative noninvasive marker for renal allograft rejection and other etiologies of injury such as BK nephropathy. The…
2021 American Transplant Congress
Angiotensin II Type-1 Receptor Antibodies are Associated with Inferior Renal Allograft Survival
P. Martin, E. Santos, N. Gunby, M. Willicombe
Renal Department, Imperial College Healthcare NHS Trust, London, United Kingdom
*Purpose: AT1R-antibodies have been implicated in antibody-mediated vascular rejection in the absence of detectable HLA donor specific antibody (DSA), in addition to cardiovascular diseases. Transplant…
2021 American Transplant Congress
De Novo Donor Specific Antibodies After Heart Transplantation in Fontan Patients with Protein Losing Enteropathy
D. A. Magnetta¹, V. Hoch², D. Pinelli³, M. Monge⁴, E. Pahl¹, P. T. Thrush¹
¹Pediatric Cardiology, Lurie Children's Hospital, Chicago, IL, ²Northwestern School of Medicine, Chicago, IL, ³Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Pediatric Cardiothoracic Surgery, Lurie Children's Hospital, Chicago, IL
*Purpose: Protein Losing Enteropathy (PLE) complicates Fontan physiology and can be an indication for heart transplantation (HT). PLE is accompanied by immune dysregulation, potentially impacting…