Articles tagged "Antibodies"

2021 American Transplant Congress
Quantification of Multiple Isotypes of Anti-SARS-CoV-2 Antibodies in Kidney Transplant Recipients
J. S. Maltzman¹, L. Wang¹, P. Ahearn¹, T. Yalamarti¹, M. Menon², Y. Azzi³, M. Melcher¹, M. Fernandez-Vina¹, R. Bray⁴, H. Gebel⁴, E. Woodle⁵, E. Akalin³, A. Girnita¹, P. Cravedi²
¹Stanford University, Palo Alto, CA, ²Icahn School of Medicine, NYC, NY, ³Einstein School of Medicine, NYC, NY, ⁴Emory University, Atlanta, GA, ⁵University of Cincinnati, Cincinnati, OH
*Purpose: Solid organ transplant recipients are at increased risk of severe outcomes with infection by SARS-CoV-2, the etiologic agent of COVID-19. Antibodies directed against the…
2021 American Transplant Congress
Impaired Antibody Responses to Spike Protein Antigens of Sars-cov-2 in Solid Organ Transplant (sot) Recipients
C. Ashokkumar¹, S. Nadig², V. Rohan², A. Kroemer³, H. Dhani³, S. Rao⁴, R. Sindhi⁵
¹Plexision, pittsburgh, PA, ²Medical University of South Carolina, Charleston, SC, ³MedStar Georgetown Transplant Institute, Georgetown, DC, ⁴DHR Health Institute for Research and Development, Texas, TX, ⁵University of Pittsburgh, Pittsburgh, PA
*Purpose: Chronic immunosuppression can impair antibody responses after natural infection and vaccination in SOT recipients. It is not known whether antibody responses are impaired in…
2021 American Transplant Congress
Seroprevalence of SARS-CoV-2 Antibodies in Transplant Recipients in a Croatian Transplant Center
A. Mrzljak¹, Z. Jurekovic¹, J. Pavicic Saric², L. Antolasic³, L. Milasincic³, I. Tabain³, T. Vilibic Cavlek³
¹Department of Internal Medicine, Merkur University Hospital, Zagreb, Croatia, ²Department of Anesthesiology, Merkur University Hospital, Zagreb, Croatia, ³Department of Microbiology, Croatian Institute of Public Health, Zagreb, Croatia
*Purpose: In Croatia, the first case of coronavirus disease (COVID-19) has been reported on 25 February 2020; however, the COVID-19 seroprevalence in the liver (LTR)…
2021 American Transplant Congress
Extracellular Matrix Injury of Kidney Allografts in Antibody-mediated Rejection
S. Clotet Freixas¹, C. McEvoy¹, I. Batruch², C. Pastrello³, M. Kotlyar³, J. Van¹, M. Arambewela¹, A. Boshart¹, S. Farkona¹, Y. Niu³, Y. Li¹, O. Famure¹, A. Bozovic⁴, V. Kulasingam⁴, P. Chen¹, J. S. Kim¹, E. Chan⁵, S. Moshkelgosha¹, S. A. Rahman⁶, J. Das⁶, T. Martinu¹, S. Juvet¹, I. Jurisica³, A. Chruscinski¹, R. John¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada, ⁶Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Antibody-mediated rejection (AMR) accounts for >50% of kidney graft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in glomeruli…
2021 American Transplant Congress
Covid-19 Reinfection in a Kidney Transplant Patient
Z. Saeed Zafar, D. Malhotra
Nephrology, Yale School of Medicine, New Haven, CT
*Purpose: Several cases have demonstrated positive SARS-CoV-2 PCR testing in patients who were initially shown to have cleared the infection. These reinfections may represent new…
2021 American Transplant Congress
Short-term Therapy with Anti-icam-1 Monoclonal Antibody Induced Long-term Liver Allograft Survival in Non-human Primates
S. Hong¹, D. Han², S. Lee², J. Kim³, E. Hwang³, H. Kim⁴, J. Lee⁵, K. Hong¹, E. Han¹, J. Cho¹, J. Lee¹, Y. Choi¹, K. Lee¹, N. Yi¹, J. Yang¹, K. Suh¹
¹Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of, ³Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Pathology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁵Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Tolerance induction remains challenging following liver transplantation and the long-term use of immunosuppressants, especially calcineurin inhibitors, leads to serious complications. We aimed to test…
2021 American Transplant Congress
The Relevance of Naturally Occurring Non-HLA Antibody to Antibody Mediated Rejection in Patients without Anti-HLA Antibodies After Kidney Transplantation
H. Ishida¹, T. Shimizu², K. Unagami³, H. Shirakawa¹, K. Tanabe¹
¹Tokyo Womens, Tokyo 162-8666, Japan, ²Urology, Tokyo Womens, Tokyo 162-8666, Japan, ³Nephrology, Tokyo Womens, Tokyo 162-8666, Japan
*Purpose: Very few papers describe the association between non-HLA antibodies and the incidence of antibody mediated rejection (AMR) in kidney recipients. We investigated the incidence…
2021 American Transplant Congress
A Comparison of Plasmapheresis Methods in the Treatment of Late Antibody Mediated Rejection
Y. Caliskan¹, H. Yazici², A. B. Dirim², E. Aksoy², S. Safak², N. Garayeva², S. Mirioglu², O. Yegit², O. A. Oto², Y. Ozluk³, S. Besisik⁴, A. Turkmen², K. Lentine¹
¹Saint Louis University, Saint Louis, MO, ²Division of Nephrology, Istanbul University, Istanbul, Turkey, ³Department of Pathology, Istanbul University, Istanbul, Turkey, ⁴Division of Hematology, Istanbul University, Istanbul, Turkey
*Purpose: Effective management to prevent allograft loss after late antibody mediated rejection (ABMR) in kidney transplant (KTx) recipients remains a vexing clinical challenge. While plasma…
2021 American Transplant Congress
Desensitization with Plasmapheresis and IV Immunoglobulin is Safe and Effective in Pra Positive Kidney Transplant Recipient Candidates in Covid-19 Pandemic Period
B. Sayin¹, A. Akdur², E. Karakaya², U. Musabak³, T. Colak¹, M. Haberal²
¹Department of Nephrology, Baskent University, Ankara, Turkey, ²Division of Transplantation, Department of General Surgery, Baskent University, Ankara, Turkey, ³Department of Immunology, Baskent University, Ankara, Turkey
*Purpose: High panel reactive antibody (PRA) levels may limit living-donor kidney transplantation (LDKT) according to increased risk of antibody mediated rejection. Desensitization may provide better…
2021 American Transplant Congress
Development of De Novo Antibody in Renal Transplant Recipients with BK Viremia Managed with Immunosuppression Reduction
R. Hod Dvorai¹, R. Lee², P. Muluhngwi², M. Raijmakers³, A. Shetty², A. Tambur², M. Ison²
¹SUNY Upstate Medical University, Syracuse, NY, ²Northwestern University, Chicago, IL, ³University of Santiago, Santiago, Chile
*Purpose: To evaluate development of de novo donor specific antibodies (dnDSA) in Renal Transplant Recipients (RTR) with immunosuppression (IS) modulation due to BK viremia (BKV)…