ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Anergy"

  • 2018 American Transplant Congress

    Acute Murine CMV Infection Results in Loss of Intragraft CD73HIFR4HIPD1+ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients

    A. Dangi,1 L. Zhang,1 X. Zhang,2 X. Luo.1,2

    1Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.

    Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…
  • 2017 American Transplant Congress

    A New and Potent Distal Enhancer of the IL2 Gene.

    R. Thomas,1 P. Mehra,1 M. Johnson,2 S. Grant,2 A. Wells.1

    1Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA; 2Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA

    Interleukin-2 is a potent T cell growth factor with crucial roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role…
  • 2017 American Transplant Congress

    Does an Indeterminate Result on Pre-Transplantation Tuberculosis Interferon Gamma Release Assay Predict Risk for Post-Transplantation Infection or Rejection?

    A. Zimmer,1 R. Razonable.2

    1Infectious Diseases, University of Nebraska Medical Center, Omaha, NE; 2Transplant Center, Mayo Clinic, Rochester, MN

    Purpose: Most centers use interferon gamma release assays (IGRA) to screen for latent TB in transplant candidates. Some of them have an indeterminate result due…
  • 2016 American Transplant Congress

    Functional Capacity Pre-Transplantation Measured by 6 Minute Walk Test and Clinical Outcomes.

    T. Alhamad,1 K. Lentine,2 S. Anwar,3 T. Maw,1 T. Horwedel,1 J. Peng,1 K. Saffaf,1 J. Hagopian,1 R. Delos Santos,1 A. Malone,1 D. Brennan.1

    1Washington University, St. Louis; 2Saint Louis University, St. Louis; 3Newcastle Hospital, Newcastle, United Kingdom.

    Background:The 6 minute walk is an inexpensive, low-technology test for measuring a patient's functional capacity and overall fitness. The utility of 6 minute walk test…
  • 2015 American Transplant Congress

    Noncanonical Anergic Alloreactive B Cells in Transplantation Tolerance

    J. Chen, M. Daniels, D. Yin, R. Sciammas, A. Chong.

    Depart of Surgery, University of Chicago, Chicago.

    The observation that operationally tolerant patients (TOL) display higher numbers of blood B cells and a B cell gene signature compared to stable kidney allograft…
  • 2015 American Transplant Congress

    Myeloid Cells as a Key Mediator for Impairment of Transplant Tolerance by CMV Infection

    L. Zhang,1 X. Zhang,2 H. Kang,1 X.-F. Liu,2 S. Yan,2 J.-J. Wang,2 M. Abecassis,2 Z. Zhang,2 M. Hummel,2 X. Luo.1,2

    1Medicine, Northwestern University Feinberg school of Medicine, Chicago, IL; 2Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Cytomegalovirus (CMV) is a ubiquitous virus that presents a significant risk for reactivation or de novo infection in transplant recipients. Clinical transplant tolerance has recently…
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