2021 American Transplant Congress
The Development and Characterization of AT1501, an Anti CD40L Antibody Lacking Fc Effector Function
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory type II membrane receptor for CD40. The binding of CD40L on T helper cells to CD40 on antigen presenting cells…2021 American Transplant Congress
Pharmacokinetic and Toxicity Studies of an Anti CD40L Antibody, At-1501 in Rhesus Macaques
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory receptor for CD40 found on T helper cells. Binding of CD40L on T cells to CD40 on antigen presenting cells…2021 American Transplant Congress
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of At-1501
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: Execute a phase 1 study of AT-1501 to assess safety, pharmacokinetics, and functional activity.*Methods: The study employed a placebo-controlled, sequential, dose-escalation design. 28 healthy…2020 American Transplant Congress
Incident Influenza Cases and Missed Opportunities for Vaccination among Solid Organ Transplant Recipients
New York University School of Medicine, New York, NY
*Purpose: The aim of this study was to identify missed opportunities for high-dose (HD) influenza vaccination among solid organ transplant (SOT) recipients and improve influenza…2019 American Transplant Congress
Murine Cmv Infection Impairs Transplantation Tolerance: A Critical Role Of Intragraft Anergic Cd4 T Cells
1Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL
*Purpose: It is well known that certain infections can impair the stability of transplantation tolerance in recipients who had prolonged functional grafts, resulting in graft-loss.…2019 American Transplant Congress
Responder B Cell Depletion Increased Allo-Reactive Regulatory T Cells Generated in Allo-Anergization
*Purpose: Regulatory T cells (Tregs) are promising tool for induction and maintenance of transplantation tolerance. We have done a feasibility trial in kidney transplant recipients…2018 American Transplant Congress
Acute Murine CMV Infection Results in Loss of Intragraft CD73HIFR4HIPD1+ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients
Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…2017 American Transplant Congress
A New and Potent Distal Enhancer of the IL2 Gene.
Interleukin-2 is a potent T cell growth factor with crucial roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role…2017 American Transplant Congress
Does an Indeterminate Result on Pre-Transplantation Tuberculosis Interferon Gamma Release Assay Predict Risk for Post-Transplantation Infection or Rejection?
Purpose: Most centers use interferon gamma release assays (IGRA) to screen for latent TB in transplant candidates. Some of them have an indeterminate result due…2016 American Transplant Congress
Functional Capacity Pre-Transplantation Measured by 6 Minute Walk Test and Clinical Outcomes.
Background:The 6 minute walk is an inexpensive, low-technology test for measuring a patient's functional capacity and overall fitness. The utility of 6 minute walk test…
American Transplant Congress abstracts