2022 American Transplant Congress
TIM-4 Identifies Proinflammatory B Cells Expressing an IL-23-Driven “Proinflammatory Module”
1University of Pittsburgh, Pittsburgh, PA, 2Thomas E Starzl Transplant Institute, Pittsburgh, PA
*Purpose: B cells play important Ab-independent roles promoting or inhibiting immune responses through the opposing activity of Bregs and poorly understood effector B cells (Beff)…2022 American Transplant Congress
Sustained Alloantigen Exposure Reinforces Transplantation Tolerance
*Purpose: While advances have been made in therapies that achieve tolerance in mouse transplant models, successful tolerance is still vulnerable to inflammatory challenges that can…2022 American Transplant Congress
Anti-CD80/86 Antibody (RM80/GL-1) Suppressed Murine Donor Specific Antibody Through Anergy CD4+T Cells
*Purpose: The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells may play an important role in alloimmune responses. We investigated…2022 American Transplant Congress
Role of Group 2 Innate Lymphoid Cells in Murine Heart Transplant
*Purpose: Group 2 innate lymphoid cells (ILC2s) have been shown to play key roles in manipulating adaptive immunity. They regulate CD4+ T cell biology not…2021 American Transplant Congress
The Development and Characterization of AT1501, an Anti CD40L Antibody Lacking Fc Effector Function
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory type II membrane receptor for CD40. The binding of CD40L on T helper cells to CD40 on antigen presenting cells…2021 American Transplant Congress
Pharmacokinetic and Toxicity Studies of an Anti CD40L Antibody, At-1501 in Rhesus Macaques
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory receptor for CD40 found on T helper cells. Binding of CD40L on T cells to CD40 on antigen presenting cells…2021 American Transplant Congress
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of At-1501
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: Execute a phase 1 study of AT-1501 to assess safety, pharmacokinetics, and functional activity.*Methods: The study employed a placebo-controlled, sequential, dose-escalation design. 28 healthy…2020 American Transplant Congress
Incident Influenza Cases and Missed Opportunities for Vaccination among Solid Organ Transplant Recipients
New York University School of Medicine, New York, NY
*Purpose: The aim of this study was to identify missed opportunities for high-dose (HD) influenza vaccination among solid organ transplant (SOT) recipients and improve influenza…2019 American Transplant Congress
Murine Cmv Infection Impairs Transplantation Tolerance: A Critical Role Of Intragraft Anergic Cd4 T Cells
1Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL
*Purpose: It is well known that certain infections can impair the stability of transplantation tolerance in recipients who had prolonged functional grafts, resulting in graft-loss.…2019 American Transplant Congress
Responder B Cell Depletion Increased Allo-Reactive Regulatory T Cells Generated in Allo-Anergization
*Purpose: Regulatory T cells (Tregs) are promising tool for induction and maintenance of transplantation tolerance. We have done a feasibility trial in kidney transplant recipients…
American Transplant Congress abstracts