2019 American Transplant Congress
Murine Cmv Infection Impairs Transplantation Tolerance: A Critical Role Of Intragraft Anergic Cd4 T Cells
1Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL
*Purpose: It is well known that certain infections can impair the stability of transplantation tolerance in recipients who had prolonged functional grafts, resulting in graft-loss.…2019 American Transplant Congress
Responder B Cell Depletion Increased Allo-Reactive Regulatory T Cells Generated in Allo-Anergization
*Purpose: Regulatory T cells (Tregs) are promising tool for induction and maintenance of transplantation tolerance. We have done a feasibility trial in kidney transplant recipients…2018 American Transplant Congress
Acute Murine CMV Infection Results in Loss of Intragraft CD73HIFR4HIPD1+ CD4 T Cells and Graft Rejection in Previously Tolerant Recipients
Background: Transplantation tolerance in human recipients has been achieved in recent trials. Nevertheless, the impact of highly prevalent and clinically relevant cytomegalovirus (CMV) infection on…2017 American Transplant Congress
A New and Potent Distal Enhancer of the IL2 Gene.
Interleukin-2 is a potent T cell growth factor with crucial roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role…2017 American Transplant Congress
Does an Indeterminate Result on Pre-Transplantation Tuberculosis Interferon Gamma Release Assay Predict Risk for Post-Transplantation Infection or Rejection?
Purpose: Most centers use interferon gamma release assays (IGRA) to screen for latent TB in transplant candidates. Some of them have an indeterminate result due…2016 American Transplant Congress
Functional Capacity Pre-Transplantation Measured by 6 Minute Walk Test and Clinical Outcomes.
Background:The 6 minute walk is an inexpensive, low-technology test for measuring a patient's functional capacity and overall fitness. The utility of 6 minute walk test…2015 American Transplant Congress
Noncanonical Anergic Alloreactive B Cells in Transplantation Tolerance
Depart of Surgery, University of Chicago, Chicago.
The observation that operationally tolerant patients (TOL) display higher numbers of blood B cells and a B cell gene signature compared to stable kidney allograft…2015 American Transplant Congress
Myeloid Cells as a Key Mediator for Impairment of Transplant Tolerance by CMV Infection
Cytomegalovirus (CMV) is a ubiquitous virus that presents a significant risk for reactivation or de novo infection in transplant recipients. Clinical transplant tolerance has recently…
American Transplant Congress abstracts