2022 American Transplant Congress
TIM-4 Identifies Proinflammatory B Cells Expressing an IL-23-Driven “Proinflammatory Module”
1University of Pittsburgh, Pittsburgh, PA, 2Thomas E Starzl Transplant Institute, Pittsburgh, PA
*Purpose: B cells play important Ab-independent roles promoting or inhibiting immune responses through the opposing activity of Bregs and poorly understood effector B cells (Beff)…2022 American Transplant Congress
Sustained Alloantigen Exposure Reinforces Transplantation Tolerance
*Purpose: While advances have been made in therapies that achieve tolerance in mouse transplant models, successful tolerance is still vulnerable to inflammatory challenges that can…2022 American Transplant Congress
Anti-CD80/86 Antibody (RM80/GL-1) Suppressed Murine Donor Specific Antibody Through Anergy CD4+T Cells
*Purpose: The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells may play an important role in alloimmune responses. We investigated…2022 American Transplant Congress
Role of Group 2 Innate Lymphoid Cells in Murine Heart Transplant
*Purpose: Group 2 innate lymphoid cells (ILC2s) have been shown to play key roles in manipulating adaptive immunity. They regulate CD4+ T cell biology not…2021 American Transplant Congress
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of At-1501
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: Execute a phase 1 study of AT-1501 to assess safety, pharmacokinetics, and functional activity.*Methods: The study employed a placebo-controlled, sequential, dose-escalation design. 28 healthy…2021 American Transplant Congress
Pharmacokinetic and Toxicity Studies of an Anti CD40L Antibody, At-1501 in Rhesus Macaques
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory receptor for CD40 found on T helper cells. Binding of CD40L on T cells to CD40 on antigen presenting cells…2021 American Transplant Congress
The Development and Characterization of AT1501, an Anti CD40L Antibody Lacking Fc Effector Function
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory type II membrane receptor for CD40. The binding of CD40L on T helper cells to CD40 on antigen presenting cells…2020 American Transplant Congress
Incident Influenza Cases and Missed Opportunities for Vaccination among Solid Organ Transplant Recipients
New York University School of Medicine, New York, NY
*Purpose: The aim of this study was to identify missed opportunities for high-dose (HD) influenza vaccination among solid organ transplant (SOT) recipients and improve influenza…2019 American Transplant Congress
Murine Cmv Infection Impairs Transplantation Tolerance: A Critical Role Of Intragraft Anergic Cd4 T Cells
1Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL
*Purpose: It is well known that certain infections can impair the stability of transplantation tolerance in recipients who had prolonged functional grafts, resulting in graft-loss.…2019 American Transplant Congress
Responder B Cell Depletion Increased Allo-Reactive Regulatory T Cells Generated in Allo-Anergization
*Purpose: Regulatory T cells (Tregs) are promising tool for induction and maintenance of transplantation tolerance. We have done a feasibility trial in kidney transplant recipients…
American Transplant Congress abstracts