2018 American Transplant Congress
Donor Deficiency of RIP3 Phosphokinase Activity Shortens Cardiac Allograft Survival in the Setting of Costimulation Blockade
Surgery, Duke University, Durham, NC.
Receptor-interacting protein kinase 3 (RIP3) is critical for necroptosis in the setting of inflammation. It has been shown that kidney and heart allografts deficient in…2018 American Transplant Congress
Delayed Achievement of Therapeutic Tacrolimus Levels after Renal Transplantation is Not Associated with Increased Incidence of Early Acute Rejection: Single-Center Results
Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA.
Induction therapy followed by maintenance with a calcineurin inhibitor aims to minimize the incidence of early rejection and optimize the potential for allograft function. However…2018 American Transplant Congress
Enrichment of Endogenous Donor-Reactive Tregs in the Spleen and Graft during Transplantation Tolerance is the Result of Treg Proliferation and Conversion from Tconv
Surgery and Medicine, University of Chicago, Chicago, IL.
Foxp3+ regulatory T cells (Tregs) are critical mediators of immune tolerance and are absolutely required for allograft tolerance in animal models. In addition, clinical trials…2018 American Transplant Congress
Identification of Human SIRPa Diversity That Could Regulate Innate Allorecognition
Innate allorecognition is a process by which myeloid cells, such as monocytes, distinguish syngeneic from allogeneic cells. Monocytes that recognize donor cells as non-self differentiate…2017 American Transplant Congress
Nephrectomy of the Failed First Kidney Allograft Predisposes Kidney Transplant Recipients to Presensitization with Alloreactive T-Cells and Inferior Allograft Survival After Retransplantation.
During the last two decades the number of recipients (KTRs) of a previous kidney transplantation being evaluated and waitlisted for a subsequent kidney transplantation has…2017 American Transplant Congress
Donor SIRPa Polymorphism Modulates the Innate Immune Response to Allogeneic Grafts.
Mice devoid of T, B, NK, and innate lymphoid cells distinguish between self and allogeneic non-self despite the absence of an adaptive immune system. When…2017 American Transplant Congress
Donor Factors Show Low Impact on Patient and Kidney Allograft Outcomes: A Paired Analysis of Left/Right Deceased Donor Kidney Pairs.
The impact of donor factors on kidney allograft outcomes and infectious complications has been suggested in many previous studies. However, analyses of left/right donor kidney…2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…2017 American Transplant Congress
Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.
1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC
Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…2017 American Transplant Congress
Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.
Background:CD8+ memory T cells produce IFN-g in a faster and stronger fashion than their naïve counterparts after allorecognition. Unmanipulated mice possess a proportion of endogenous…
- « Previous Page
- 1
- …
- 7
- 8
- 9
- 10
- 11
- …
- 16
- Next Page »