2018 American Transplant Congress
Identification of Macrophage Innate Receptors in Recognition and Rejection of Allogeneic Non-Self in Transplantation
Recent studies in several labs provide compelling evidence that the innate immune cells can recognize and reject allogeneic non-self in an antigen-specific manner, but the…2018 American Transplant Congress
C3a Receptor Regulates the CD8 T-Cell Alloresponse via Intrinsic and Extrinsic Mechanisms
Icahn School of Medicine at Mount Sinai, NY, NY.
The role of complement in solid organ transplantation continues to evolve with our enhanced understanding of complement's regulation of the alloresponse. Prior work has shown…2018 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Myeloid-Derived Suppressor Cells Differentiation and Enhances Its Immunosuppressive Function of in Allograft Immunity
Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…2017 American Transplant Congress
Reduction of Recipient Cell Cross-Dressing with Donor MHC Molecules Prolongs Allograft Survival in Mice.
Cross-dressing of recipient cells with allogeneic MHC molecules carried by donor exosomes occurs regularly after transplantation. However, it is still unknown whether this phenomenon plays…2017 American Transplant Congress
Donor Leukocytes Are Eliminated by the Host's Immune System Shortly After Skin Transplantation in Mice.
We have recently reported the lack of donor passenger leukocytes in the recipient's lymphoid organs of mice recipient of a skin allograft. On the other…2017 American Transplant Congress
2B4-Mediated Inhibition of Proliferation and Glycolytic Function Attenuates T Cell Alloreactivity.
Emory Transplant Center, Atlanta, GA
Current thinking holds that costimulation-blockade resistant graft rejection may be mediated by CD28null T cells. To further investigate this possibility, we performed a retrospective immunophenotypic…2017 American Transplant Congress
Does HLA Class of Complement Activating Donor Specific Antibodies Matter: Single Centre Retrospective Analysis of Renal Allograft Outcomes.
Introduction. Complement activating donor specific antibodies may be associated with worse outcomes in a cohort of patients who have undergone HLA-AIT. We looked for differences…2017 American Transplant Congress
Rapamycin Directly Alters Human Endothelial Cell Alloimmunogenicity.
The mTOR inhibitor rapamycin (Rapa) is known to suppress T cell function. However, many of its in vivo effects, particularly its synergistic effects with costimulation…2017 American Transplant Congress
Exosomes Containing IL35 Are Secreted by Donor-Specific Regulatory T Cells and Cause Linked-Suppression.
Introduction: We previously reported that donor specific splenocytes transfusion (DST) plus anti-CD40L costimulatory blockade treatment causes allo-specific regulation approximately 5 weeks after the tolerization. The…
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