Articles tagged "Allorecognition"

2018 American Transplant Congress
Identification of Macrophage Innate Receptors in Recognition and Rejection of Allogeneic Non-Self in Transplantation
P. Lan,¹ H. Dai,² W. Liu,¹ S. Chen,¹ L. Minze,¹ Y. Dou,¹ Y. Zhao,¹ W. Chen,¹ X. Xiao,¹ P. Pan,¹ H-.H. Chen,¹ F. Lakkis,² X. Li.¹
¹Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; ²Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Recent studies in several labs provide compelling evidence that the innate immune cells can recognize and reject allogeneic non-self in an antigen-specific manner, but the…
2018 American Transplant Congress
C3a Receptor Regulates the CD8 T-Cell Alloresponse via Intrinsic and Extrinsic Mechanisms
J. Horwitz, D. Mathern, P. Heeger.
Icahn School of Medicine at Mount Sinai, NY, NY.
The role of complement in solid organ transplantation continues to evolve with our enhanced understanding of complement's regulation of the alloresponse. Prior work has shown…
2018 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Myeloid-Derived Suppressor Cells Differentiation and Enhances Its Immunosuppressive Function of in Allograft Immunity
C. Yang, T. Zhu.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
S. Gibney,¹ M. Efre,¹ T. Ashry,¹ C. Yang,¹ T. O'Shea,^1,2 R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…
2018 American Transplant Congress
Myeloid Derived Suppressor Cells Are Induced after Transplantation and Home to the Transplanted Kidney
Y. Lee, E. Davila, J. Bromberg, J. Scalea.
Surgery and Immunology, University of Maryland, Baltimore, MD.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a naturally occurring, heterogeneous population of highly immunosuppressive cells which expand in response to inflammatory conditions such as cancer.…
2018 American Transplant Congress
Anti-Thymocyte Globulin Directly Binds and Functionally Inhibits Allo-Regulatory Myeloid Derived Suppressor Cells
Y. Lee, E. Davila, J. Bromberg, J. Scalea.
Surgery and Immunology, University of Maryland, Baltimore, MD.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of naturally occurring, immunosuppressive cells that may be exploitable in transplantation.There are only a few incomplete…
2018 American Transplant Congress
Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells
W. Hassanein,¹ P. Patel,¹ A. Werdsheim,¹ J. Brilliant,¹ E. Buckingham,¹ N. Shockcor,¹ C. Drachenberg,² R. Barth,¹ J. LaMattina.¹
¹Surgery, University of Maryland, Baltimore, MD; ²Pathology, University of Maryland, Baltimore, MD.
Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…
2018 American Transplant Congress
Immune Profiling in Highly Sensitized Kidney Transplant Recipients
S. Negi, A. Rutman, S. Paraskevas, J. Tchervenkov.
Surgery, McGill University, Montreal, Canada.
Introduction: Highly sensitized patients (HSP) express foreign HLA antibodies and have poor graft survival due to higher incidences of graft rejection as compared to non-sensitized…
2018 American Transplant Congress
Origin and Traffic of Donor-Derived Extracellular Vesicles during Allo-Sensitization
F. Zeng,¹ W. Shufesky,¹ M. Yang,¹ Q. Liu,¹ A. Larregina,² A. Morelli.¹
¹T.E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ²Department of Dermatology, University of Pittsburgh, Pittsburgh, PA.
The idea that donor dendritic cells (DCs) transplanted with the grafts and mobilized to draining lymphoid tissues (dLTs) present donor MHC molecules to allo-reactive naïve…
2018 American Transplant Congress
Searching for Recipient-HLA Class II and Donor-HLA-Derived Peptide Complexes Inducing Protective Effect against De Novo Donor-Specific HLA Antibodies Formation in Kidney Transplantation
T. Tomosugi,¹ K. Iwasaki,¹ M. Okumura,¹ Y. Matsuoka,¹ K. Horimi,¹ M. Okada,² Y. Watarai,² T. Kobayashi.¹
¹Kidney Transplant Surgery, Aichi Medical University, Nagakute, Aichi, Japan; ²Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan.
De novo donor-specific HLA antibodies (dnDSA) are recognized as a risk factor for late deterioration of renal allograft function. dnDSA production occurs via the indirect…

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