2019 American Transplant Congress
Can Imputation of HLA Allele Level Typing Be Used Clinically in a Multiethnic Population?
*Purpose: Assignment of eplets in transplantation for the purpose of matching or risk stratification requires high-resolution HLA typing, which is not readily available. Computer algorithms…2019 American Transplant Congress
High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity
*Purpose: Measurement of T cell alloreactivity may facilitate a more accurate prediction of graft outcome and the selection of patients for immunosuppression optimization. However, current…2019 American Transplant Congress
Humoral Immune Responses to Kidney Associated Non-HLA Antigens is Not Associated with Progression to Chronic Immune Injury in Kidney Transplant Recipients
1Mayo Clinic, Phoenix, AZ, 2St. Joseph’s Hospital, Phoenix, AZ
*Purpose: Development of donor specific anti-HLA (DSA) although is a known risk factor for Chronic immune injury (CII), it is undetectable in many patients with…2019 American Transplant Congress
IL-10+ Plasma Cells Are Not Required for Breg Activity and Are Counterbalanced by Novel Pro-Inflammatory Plasma Cells
University of Pittsburgh, Pittsburgh, PA
*Purpose: Classically, B cells differentiate into Ab-secreting plasma cells (PCs; B220lowCD138hiBlimp1+Ig+) providing humoral immunity. B cells can also inhibit or promote immune responses through the…2019 American Transplant Congress
Tolerogenic Nanoparticles Targeting the Aryl Hydrocarbon Receptor
*Purpose: The aryl hydrocarbon receptor (AHR) has been shown to have a central role in the ability of dendritic cells (DCs) to direct differentiation of…2019 American Transplant Congress
Towards Human Leukocyte Antigen Immunogenicity Assessment at the Individual Patient Level
*Purpose: Allorecognition of donor HLA and induction of humoral alloimmunity is a major cause of graft loss after solid-organ transplantation. Current approaches to study molecular…2018 American Transplant Congress
Identification of Macrophage Innate Receptors in Recognition and Rejection of Allogeneic Non-Self in Transplantation
Recent studies in several labs provide compelling evidence that the innate immune cells can recognize and reject allogeneic non-self in an antigen-specific manner, but the…2018 American Transplant Congress
C3a Receptor Regulates the CD8 T-Cell Alloresponse via Intrinsic and Extrinsic Mechanisms
Icahn School of Medicine at Mount Sinai, NY, NY.
The role of complement in solid organ transplantation continues to evolve with our enhanced understanding of complement's regulation of the alloresponse. Prior work has shown…2018 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Myeloid-Derived Suppressor Cells Differentiation and Enhances Its Immunosuppressive Function of in Allograft Immunity
Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…
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