ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Allorecognition"

  • 2019 American Transplant Congress

    Towards Human Leukocyte Antigen Immunogenicity Assessment at the Individual Patient Level

    H. Copley1, H. McDowell2, D. Pinelli2, A. R. Tambur2, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Surgery, Feinberg School of Medicine, Comprehensive Transplant Center, Northwestern University, Chicago, IL

    *Purpose: Allorecognition of donor HLA and induction of humoral alloimmunity is a major cause of graft loss after solid-organ transplantation. Current approaches to study molecular…
  • 2019 American Transplant Congress

    Myeloid AXL Promotes Cardiac Allograft Vasculopathy

    K. E. Glinton1, X. Yeap1, Z. J. Zhang2, X. Luo3, E. B. Thorp1

    1Pathology, FCVRRI, Northwestern University - Feinberg School of Medicine, Chicago, IL, 2Surgery, Northwestern University - Feinberg School of Medicine, Chicago, IL, 3Duke Transplant Center, Duke University School of Medicine, Durham, NC

    *Purpose: Cardiac Allograft Vasculopathy (CAV) is a significant contributor to long term transplant rejection, despite advances in immunotherapy. Reactivity to alloantigen presentation may occur by…
  • 2019 American Transplant Congress

    Heart En Bloc Thymus Cotransplantation in NHPs

    J. O1, W. Sommer2, K. Pruner3, J. T. Paster4, I. M. Hanekamp1, A. Dehnadi1, I. Rosales1, R. N. Smith1, R. B. Colvin1, G. Benichou1, J. S. Allan1, J. C. Madsen1

    1Center for Transplantation Sciences, MGH, Boston, MA, 2Hannover Medical School, Hannover, Germany, 3University of Washington, Seattle, WA, 4MGH, Boston, MA

    *Purpose: Tolerance of isolated cardiac allografts has never been achieved in NHPs. We investigated whether a cotransplanted, vascularized, donor thymus could induce tolerance of a…
  • 2019 American Transplant Congress

    Murine Cmv Infection Impairs Transplantation Tolerance: A Critical Role Of Intragraft Anergic Cd4 T Cells

    A. Dangi1, E. B. Thorp2, X. Luo1

    1Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL

    *Purpose: It is well known that certain infections can impair the stability of transplantation tolerance in recipients who had prolonged functional grafts, resulting in graft-loss.…
  • 2019 American Transplant Congress

    Predicted Indirectly Recognizable H L A Epitopes Are Associated with T-cell Mediated Rejection among Kidney Transplant Recipients with Preformed and De Novo Donor-Reactive T-cells

    T. Schachtner1, M. Stein2, N. M. Otto3, P. M. Reinke2

    1Nephrology, University Hospital Zurich, Zurich, Switzerland, 2Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany, 3Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berin, Germany

    *Purpose: Very recently Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) have been suggested to demonstrate early and late effects on kidney allograft outcomes. The association between…
  • 2019 American Transplant Congress

    Regulating T Cell Responses by Forced Transgenic Expression of Decay-Accelerating Factor

    D. Heja1, Z. He1, S. A. Lira1, F. Lin2, D. Homann1, P. S. Heeger1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Cleveland Clinic, Cleveland, OH

    *Purpose: Decay-accelerating factor (DAF, CD55) is a cell surface expressed, glycophosphatidylinositol-(GPI)-anchored, complement regulator. Previous studies showed that during cognate T cell/antigen presenting cell (APC) interactions…
  • 2018 American Transplant Congress

    Myeloid Derived Suppressor Cells Are Induced after Transplantation and Home to the Transplanted Kidney

    Y. Lee, E. Davila, J. Bromberg, J. Scalea.

    Surgery and Immunology, University of Maryland, Baltimore, MD.

    BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a naturally occurring, heterogeneous population of highly immunosuppressive cells which expand in response to inflammatory conditions such as cancer.…
  • 2018 American Transplant Congress

    Anti-Thymocyte Globulin Directly Binds and Functionally Inhibits Allo-Regulatory Myeloid Derived Suppressor Cells

    Y. Lee, E. Davila, J. Bromberg, J. Scalea.

    Surgery and Immunology, University of Maryland, Baltimore, MD.

    BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of naturally occurring, immunosuppressive cells that may be exploitable in transplantation.There are only a few incomplete…
  • 2018 American Transplant Congress

    Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells

    W. Hassanein,1 P. Patel,1 A. Werdsheim,1 J. Brilliant,1 E. Buckingham,1 N. Shockcor,1 C. Drachenberg,2 R. Barth,1 J. LaMattina.1

    1Surgery, University of Maryland, Baltimore, MD; 2Pathology, University of Maryland, Baltimore, MD.

    Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…
  • 2018 American Transplant Congress

    Immune Profiling in Highly Sensitized Kidney Transplant Recipients

    S. Negi, A. Rutman, S. Paraskevas, J. Tchervenkov.

    Surgery, McGill University, Montreal, Canada.

    Introduction: Highly sensitized patients (HSP) express foreign HLA antibodies and have poor graft survival due to higher incidences of graft rejection as compared to non-sensitized…
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