Articles tagged "Allorecognition"

2020 American Transplant Congress
Infectious Tolerance Depends Upon the ‘Exokine’ IL35
W. J. Burlingham¹, J. A. Sullivan¹, Y. Tomita², E. Jankowska-Gan¹, D. Lema¹, S. Hong³, D. A. Vignali⁴
¹Surgery, University of Wisconsin, Madison, WI, ²Surgery, Tokai University, Tokyo, Japan, ³Pharmacy, University of Wisconsin, Madison, WI, ⁴Immunology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Interleukin-35 (IL35) is an immunosuppressive cytokine composed of Ebi3 and p35 subunits. Yet the form(s) that IL35 assumes and its role in infectious tolerance,…
2020 American Transplant Congress
Peripheral Blood T- and B-Cells as Predictors of Acute Rejection in Pancreas Transplant Recipients
P. Ventura Aguiar¹, J. Rovira², M. Ramirez-Bajo², E. Bañón-Maneus², N. Hierro², M. Garcia Criado³, M. Cuatrecasas⁴, J. Ferrer⁵, E. Esmatjes⁶, J. Campistol¹, F. Diekmann¹
¹Nephrology and Kidney Transplantation, Hospital Clinic Barcelona, Barcelona, Spain, ²Laboratori Experimental de Nefrologia i Trasplantament, Fundacio Clinic - IDIBAPS, Barcelona, Spain, ³Radiology Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁴Pathology Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁵HepatoBilioPancreatic Surgery Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁶Endocrinology Department, Hospital Clinic Barcelona, Barcelona, Spain
*Purpose: Pancreas transplantation is associated with a high risk of acute rejection. The effect of peripheral blood mononuclear cells (PBMC) on acute rejection (AR) outcomes…
2020 American Transplant Congress
Extended HLA Typing of Kidney Transplant Pairs is Necessary to Assign Presence of Donor-Specific Anti-HLA Antibodies
A. Senev¹, V. Van Sandt², M. Naesens¹, M. Emonds¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²HILA, Rode Kruis Vlaanderen, Leuven, Belgium
*Purpose: The need for extended high-resolution (HR) HLA genotyping in solid organ transplantation is currently widely debated due to higher costs and questioned clinical importance.…
2019 American Transplant Congress
Computational Assessment of T-cell and B-cell Allorecognition to Predict Donor HLA Immunogenicity
H. C. Copley¹, M. Elango¹, V. Kosmoliaptsis²
¹Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital, Cambridge, United Kingdom, ²University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital & NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation at the University of Cambridge, Cambridge, UK., Cambridge, United Kingdom
*Purpose: Donor-specific alloantibody (DSA) development after solid-organ transplantation is a major cause of graft loss, and limits future transplant options. We have previously shown that…
2019 American Transplant Congress
Evaluating Allo-Specific CD57⁺ T Cells during Memory and Proliferative Responses
A. Lucander, H. Xu, A. Kirk
Department of Surgery, Duke University, Durham, NC
*Purpose: We have previously identified subsets of CD57+ T cells that are resistant to B7 costimulation blockade (CoB) in kidney transplant recipients. The objective of…
2019 American Transplant Congress
Can Imputation of HLA Allele Level Typing Be Used Clinically in a Multiethnic Population?
R. M. Engen¹, A. M. Jedraszko¹, A. Tambur²
¹Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, ²Northwestern University, Chicago, IL
*Purpose: Assignment of eplets in transplantation for the purpose of matching or risk stratification requires high-resolution HLA typing, which is not readily available. Computer algorithms…
2019 American Transplant Congress
High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity
S. Moshkelgosha, S. C. Juvet
UHN, Toronto, ON, Canada
*Purpose: Measurement of T cell alloreactivity may facilitate a more accurate prediction of graft outcome and the selection of patients for immunosuppression optimization. However, current…
2019 American Transplant Congress
Humoral Immune Responses to Kidney Associated Non-HLA Antigens is Not Associated with Progression to Chronic Immune Injury in Kidney Transplant Recipients
S. Sukumaran Nair¹, R. Ravichandran², R. Heilman¹, A. Jaramillo¹, D. Ramon¹, M. Buras¹, B. Kaplan¹, T. Mohanakumar²
¹Mayo Clinic, Phoenix, AZ, ²St. Joseph’s Hospital, Phoenix, AZ
*Purpose: Development of donor specific anti-HLA (DSA) although is a known risk factor for Chronic immune injury (CII), it is undetectable in many patients with…
2019 American Transplant Congress
IL-10+ Plasma Cells Are Not Required for Breg Activity and Are Counterbalanced by Novel Pro-Inflammatory Plasma Cells
Q. Ding, Y. Zhou, Z. Song, L. Zeng, D. Rothstein
University of Pittsburgh, Pittsburgh, PA
*Purpose: Classically, B cells differentiate into Ab-secreting plasma cells (PCs; B220lowCD138hiBlimp1+Ig+) providing humoral immunity. B cells can also inhibit or promote immune responses through the…
2019 American Transplant Congress
Tolerogenic Nanoparticles Targeting the Aryl Hydrocarbon Receptor
K. Janek¹, J. Fechner¹, S. Gong², Y. Wang², J. Mezrich¹
¹Department of Surgery, Division of Transplantation, University of Wisconsin Hospital and Clinics, Madison, WI, ²Department of Biomedical Engineering, University of Wisconsin Madison, Madison, WI
*Purpose: The aryl hydrocarbon receptor (AHR) has been shown to have a central role in the ability of dendritic cells (DCs) to direct differentiation of…

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