Articles tagged "Allorecognition"

2020 American Transplant Congress
Determination of Programmed Cell Death Protein 1 (PD1) by Flow Cytometry, a Possible Follow-Up Tool in Renal Transplantation of High Immune Risk
M. Carmona-Escamilla¹, M. Fonseca², J. Prieto Chávez³, L. Arriaga⁴, F. Oviendo⁵, S. , Hernández-Mendoza SA², J. Alberu⁶, G. Queipo²
¹Nephrology, Hospital Central Sur Alta Especialidad "Picacho", CDMX, Mexico, ²Genetics, Hospital General de México Dr. Eduardo Liceaga-Facultad, Ciudad de México, México, CDMX, Mexico, ³Transplant, Hospital General de México Dr. Eduardo Liceaga-Facultad, Ciudad de México, México, CDMX, Mexico, ⁴Unidad de investigación en inmunoqímica,, Hospital de Especialidades Centro Médico Siglo XXI IMSS, CDMX, Mexico, ⁵Unidad de investigación en inmunoqímica,, Hospital de Especialidades Centro Médico Siglo XXI IMSS, Ciudad de México, México, CDMX, Mexico, ⁶Transplant, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico
*Purpose: Introduction: Currently, the follow-up of patients remains to be the serum creatinine level, being highly specific, however, with little sensitivity to determine the occurrence…
2020 American Transplant Congress
Role of Innate Allorecognition Pathways in Mouse Kidney and Heart Allograft Rejection
D. Zhao¹, H. Dai¹, K. Abou-Daya¹, R. Tieu¹, A. Williams¹, M. Oberbarnscheidt¹, X. Li², F. Lakkis¹
¹Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²Houston Methodist Hospital Immunobiology & Transplant Science Center, Houston, TX
*Purpose: Paired immunoglobulin-like receptors (PIR) and CD47 are molecules expressed on host myeloid cells. They recognize donor polymorphic MHC and signal regulatory protein alpha (SIRPα),…
2020 American Transplant Congress
Flow Cytometric Characterization of Regulatory Cell Populations Expanded Ex Vivo from PBMCs of Kidney Transplant Recipients
S. Tripathi¹, P. L. Martin-Moreno², G. J. Kavalam¹, A. Chandraker¹
¹Renal, Brigham and Women's Hospital, Boston, MA, ²Nephrology, Clinica Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
*Purpose: We have previously shown that it is possible to generate alloantigen-specific regulatory T cell lines and clones that prolong allograft survival upon infusion in…
2020 American Transplant Congress
T Cell Activation by Allogeneic EVs and Allogeneic MHC Cross-Dressed Cells In Vitro and In Vivo
A. Prunevieille¹, B. Gonzalez-Nolasco¹, G. Benichou¹, N. Mooney², A. Colleen³
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²INSERM, Paris, France, ³Boston College, Boston, MA
*Purpose: The recognition of donor-MHC molecules by recipient T cells triggers the immune response leading to rejection of allografts. Our recent studies have documented the…
2020 American Transplant Congress
Costimulatory Signal Impacts Car Treg Fate and Function in Transplantation
B. Lamarthée¹, A. Marchal¹, S. Charbonnier¹, T. Blein¹, K. Vogt², M. Titeux¹, N. Pallet³, M. Delville¹, E. Six¹, D. Anglicheau⁴, C. Legendre⁴, B. Sawitzki², J. Taupin⁵, M. Cavazzana¹, I. André¹, J. Zuber¹
¹Inserm U1163, Institut Imagine, Paris, France, ²Department of Immunology, Charité University Hospital, Berlin, Germany, ³Inserm U1147, Centre Universitaire des Saints Pères, Paris, France, ⁴Service de Transplantation Rénale Adulte, Assistance Publique–Hôpitaux de Paris, Hôpital Necker, Paris, France, ⁵Inserm U1160, Centre Hayem, Paris, France
*Purpose: Donor-specific regulatory T-cell (Treg) therapy has emerged as a potent strategy to promote immune tolerance in experimental transplantation. However, a major stumbling block in…
2020 American Transplant Congress
Belatacept Suppresses the B-Cell Alloresponse in the Lower Range of Therapeutic Trough Concentrations
C. Ashokkumar¹, R. Townsend², M. Roberts², T. Lehman², B. Gavin², B. Spishock¹, R. Sindhi¹
¹Plexision, Pittsburgh, PA, ²Bristol-Myers-Squibb, Princeton, NJ
*Purpose: Background: Kidney recipients treated with the T-cell costimulation blocker, belatacept, experience a higher incidence of acute cellular rejection (ACR) and lower incidence of donor-specific…
2020 American Transplant Congress
Infectious Tolerance Depends Upon the ‘Exokine’ IL35
W. J. Burlingham¹, J. A. Sullivan¹, Y. Tomita², E. Jankowska-Gan¹, D. Lema¹, S. Hong³, D. A. Vignali⁴
¹Surgery, University of Wisconsin, Madison, WI, ²Surgery, Tokai University, Tokyo, Japan, ³Pharmacy, University of Wisconsin, Madison, WI, ⁴Immunology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Interleukin-35 (IL35) is an immunosuppressive cytokine composed of Ebi3 and p35 subunits. Yet the form(s) that IL35 assumes and its role in infectious tolerance,…
2020 American Transplant Congress
Peripheral Blood T- and B-Cells as Predictors of Acute Rejection in Pancreas Transplant Recipients
P. Ventura Aguiar¹, J. Rovira², M. Ramirez-Bajo², E. Bañón-Maneus², N. Hierro², M. Garcia Criado³, M. Cuatrecasas⁴, J. Ferrer⁵, E. Esmatjes⁶, J. Campistol¹, F. Diekmann¹
¹Nephrology and Kidney Transplantation, Hospital Clinic Barcelona, Barcelona, Spain, ²Laboratori Experimental de Nefrologia i Trasplantament, Fundacio Clinic - IDIBAPS, Barcelona, Spain, ³Radiology Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁴Pathology Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁵HepatoBilioPancreatic Surgery Department, Hospital Clinic Barcelona, Barcelona, Spain, ⁶Endocrinology Department, Hospital Clinic Barcelona, Barcelona, Spain
*Purpose: Pancreas transplantation is associated with a high risk of acute rejection. The effect of peripheral blood mononuclear cells (PBMC) on acute rejection (AR) outcomes…
2020 American Transplant Congress
Extended HLA Typing of Kidney Transplant Pairs is Necessary to Assign Presence of Donor-Specific Anti-HLA Antibodies
A. Senev¹, V. Van Sandt², M. Naesens¹, M. Emonds¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²HILA, Rode Kruis Vlaanderen, Leuven, Belgium
*Purpose: The need for extended high-resolution (HR) HLA genotyping in solid organ transplantation is currently widely debated due to higher costs and questioned clinical importance.…
2020 American Transplant Congress
Effector Differentiation of Endogenous Antigen-Specific CD8⁺ T Cells is Selectively Limited by CTLA-4 Ig
S. M. Krummey, K. P. Tong, M. L. Ford
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
*Purpose: Costimulation blockade with belatacept (CTLA-4 Ig) offers improved renal function and reduced toxicity following transplantation compared to calcineurin inhibitors. Nonetheless, episodes of acute T…