2021 American Transplant Congress
Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy
*Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…2021 American Transplant Congress
TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation
Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…2020 American Transplant Congress
Belatacept Suppresses the B-Cell Alloresponse in the Lower Range of Therapeutic Trough Concentrations
1Plexision, Pittsburgh, PA, 2Bristol-Myers-Squibb, Princeton, NJ
*Purpose: Background: Kidney recipients treated with the T-cell costimulation blocker, belatacept, experience a higher incidence of acute cellular rejection (ACR) and lower incidence of donor-specific…2020 American Transplant Congress
Infectious Tolerance Depends Upon the ‘Exokine’ IL35
*Purpose: Interleukin-35 (IL35) is an immunosuppressive cytokine composed of Ebi3 and p35 subunits. Yet the form(s) that IL35 assumes and its role in infectious tolerance,…2020 American Transplant Congress
Peripheral Blood T- and B-Cells as Predictors of Acute Rejection in Pancreas Transplant Recipients
*Purpose: Pancreas transplantation is associated with a high risk of acute rejection. The effect of peripheral blood mononuclear cells (PBMC) on acute rejection (AR) outcomes…2020 American Transplant Congress
Extended HLA Typing of Kidney Transplant Pairs is Necessary to Assign Presence of Donor-Specific Anti-HLA Antibodies
*Purpose: The need for extended high-resolution (HR) HLA genotyping in solid organ transplantation is currently widely debated due to higher costs and questioned clinical importance.…2020 American Transplant Congress
Effector Differentiation of Endogenous Antigen-Specific CD8+ T Cells is Selectively Limited by CTLA-4 Ig
Emory Transplant Center, Emory University School of Medicine, Atlanta, GA
*Purpose: Costimulation blockade with belatacept (CTLA-4 Ig) offers improved renal function and reduced toxicity following transplantation compared to calcineurin inhibitors. Nonetheless, episodes of acute T…2020 American Transplant Congress
Pleural Exosome Mediated Donor Antigen Trafficking Into Mediastinal Lymph Nodes Represents a Novel Pathway of Recipient T Cell Activation in Lung Transplantation
*Purpose: Studies in lung transplant models suggest that reestablishment of lymphatic continuum of pulmonary allograft via lymphangiogenesis is required for selective trafficking of donor antigen…2020 American Transplant Congress
Human Live Donor Liver Transplantation is Associated with Pd-l1 Expression on Donor-Exosome-Acquiring Host Dendritic Cells
Surgery- Transplantation, University of Wisconsin-Madison, Madison, WI
*Purpose: Liver transplantation (LTx) has been associated with the phenomenon of “cross-dressing” of recipient dendritic cells (DCs) by donor exosome-derived MHC antigens, and acquisition of…2020 American Transplant Congress
Next Generation Sequencing Based Analysis of the T-Cell Receptor Repertoire Reveals an Increase of Alloreactive T-Cell Clones after Kidney Transplantation
*Purpose: The development of the alloreactive T-cell repertoire after kidney transplantation (KTX) is not yet fully understood. The combination of mixed lymphocyte reaction (MLR) and…
- « Previous Page
- 1
- 2
- 3
- 4
- 5
- …
- 16
- Next Page »