2022 American Transplant Congress
High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity in Humans
University Health Network, Toronto, ON, Canada
*Purpose: Accurate measurement of T cell alloreactivity may allow prediction of graft outcome and the selection of patients for immunosuppression optimization. Current technologies cannot reliably…2022 American Transplant Congress
Donor-Specific Hyporesponsiveness Following Kidney Transplantation is Explained by Progressive Loss of Donor-Reactive Polyfunctional Cd4+ Effector Memory T Cells
Internal Medicine, Erasmus MC, Rotterdam, Netherlands
*Purpose: After kidney transplantation, donor-specific hyporesponsiveness (DSH) develops which is defined as a lowered response of alloreactive T cells to donor antigen while retaining response…2022 American Transplant Congress
Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells
*Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…2022 American Transplant Congress
Identification of Highly-Effective Donor-Reactive CD4+CD8αlo T Cells in CTLA4Ig-Treated Renal Allograft Recipient Monkeys
*Purpose: Potent CD4+CD8αlo effector T cells have been reported in transplant (tx) patients. . We evaluated the incidence and function of CD4+CD8αloT cells in renal…2022 American Transplant Congress
Are Changes in Clinical Practice Reflected in Gene Expression Profiling Scores After Heart Transplantation?
1CareDx, Brisbane, CA, 2Stanford University, Stanford, CA
*Purpose: AlloMap (AM) is a peripheral blood gene expression profiling (GEP) tool used for the assessment of acute cellular rejection in heart transplant recipients (HT).…2021 American Transplant Congress
Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy
*Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…2021 American Transplant Congress
TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation
Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…2021 American Transplant Congress
Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome
*Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…2021 American Transplant Congress
IFNγ, and to a Lesser Extent TNFα, Elicits Protracted Endothelial Cell Expression of Costimulatory Molecules and Antigen Presentation Machinery
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Beyond simply “recruiting” leukocytes to sites of injury, local stimulation by the donor vascular compartment may prolong alloimmune responses. Moreover, the dynamics of endothelial…2021 American Transplant Congress
Evaluation of the Differentiation Program of Endogenous Antigen-specific CD8+T Cells Following Transplantation
1Pathology, Johns Hopkins University, Baltimore, MD, 2Surgery, Emory Transplant Center, Atlanta, GA
*Purpose: Despite advances in the survival of transplanted organs, acute T cell mediated rejection remains a significant clinical problem with few effective or targeted treatments.…
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