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American Transplant Congress abstracts

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Articles tagged "Allorecognition"

  • 2022 American Transplant Congress

    Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets

    J. Warunek1, A. Lucas2, L. R. Mathews2, M. Oberbarnscheidt2, F. Lakkis2, H. Turnquist2

    1Immunology, Thomas E. Starzl Transplantation Institute, University at Pittsburgh, Pittsburgh, PA, 2Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…
  • 2022 American Transplant Congress

    Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression

    K. Lee, F. Qiang, K. Deng, R. Matheson, J. Lei, C. LeGuern, J. Markmann

    Center for Transplantation Sciences, Boston, MA

    *Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
  • 2022 American Transplant Congress

    NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile

    E. Bailly1, C. Macedo1, K. Louis2, X. Gu1, B. Ramaswami1, M. Lucas1, C. Bentlejewski1, A. Zeevi1, P. Randhawa1, C. Lefaucheur2, D. Metes1

    1Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 2INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Paris, France

    *Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…
  • 2022 American Transplant Congress

    Detection of Alloreactive CD8+ T Cell Responses and the Immunopeptidome That Elicits Their Activation

    A. B. Morris, X. Zhang, E. V. Peek, A. Hadley, C. Larsen

    Emory University, Atlanta, GA

    *Purpose: T cell-mediated rejection results in graft dysfunction and contributes to premature failure. Due to the complexity of the TCR:pMHC interaction, prediction of alloreactive T…
  • 2022 American Transplant Congress

    Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection

    M. Cano1, D. Zhou2, C. Chen3, K. Pugh4, D. Byers1, D. Kreisel5, R. Hachem1, A. Gelman5

    1Pulmonary and Critical Care, Washington University, Saint Louis, MO, 2Surgery, Washington University, Saint Louis, MO, 3Pulmonary and Critical Care, UT Southwestern Medical Center, Dallas, TX, 4Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 5Surgery and Immunology and Pathology, Washington University, Saint Louis, MO

    *Purpose: Bronchiolitis obliterans syndrome (BOS) remains a major cause of death after lung transplantation. Unfortunately, we lack effective treatments for BOS as the mechanisms by…
  • 2021 American Transplant Congress

    Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring

    K. R. Sherwood1, P. Wong1, F. Fenninger1, V. Wu1, J. Beckrud2, D. P. Cina3, L. Allan2, J. Lan2, P. A. Keown2

    1University of British Columbia, Vancouver, BC, Canada, 2Vancouver General Hospital, Vancouver, BC, Canada, 3Urologic Sciences, Vancouver General Hospital, Vancouver, BC, Canada

    *Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…
  • 2021 American Transplant Congress

    Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy

    R. G. Gill1, M. Coulombe2, K. S. Beard1, A. L. Burrack3

    1University of Colorado, Aurora, CO, 2Surgery, University of Colorado, Aurora, CO, 3Mircrobiology and Immunology, University of Minnesota, Minneapolis, MN

    *Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…
  • 2021 American Transplant Congress

    TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation

    A. C. van der List, N. H. Litjens, M. G. Betjes, M. Klepper

    Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands

    *Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…
  • 2021 American Transplant Congress

    Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome

    K. Janek1, J. H. Fechner1, R. A. Daley1, K. Krautkamer1, F. Rey2, J. D. Mezrich1

    1Surgery, University of Wisconsin School of Medicine & Public Health, Madison, WI, 2Bacteriology, University of Wisconsin, Madison, WI

    *Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…
  • 2021 American Transplant Congress

    IFNγ, and to a Lesser Extent TNFα, Elicits Protracted Endothelial Cell Expression of Costimulatory Molecules and Antigen Presentation Machinery

    N. M. Valenzuela

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    *Purpose: Beyond simply “recruiting” leukocytes to sites of injury, local stimulation by the donor vascular compartment may prolong alloimmune responses. Moreover, the dynamics of endothelial…
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