Articles tagged "Allorecognition"

2016 American Transplant Congress
Exposure Analysis for the Composite Efficacy Endpoints in the US92 Phase 3 Kidney Transplantation Trial to Understand Center Effects.
F. Shihab, B. Kaplan, K. McCague, D. Patel, F. Vincenti.
University of Utah, Salt Lake City; Mayo Clinic, Phoenix; Novartis Pharmaceuticals Corporation, East Hanover; University of California, San Francisco.
The US92 study determined whether, in de novo renal transplant patients, concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®, (mycophenolate…
2016 American Transplant Congress
miR-21 in Chronic Allograft Vasculopathy.
V. Usuelli,¹ M. Ben Nasr,^1,2 F. D'Addio,^1,2 L. Kaifeng,² L. Borgese,³ L. Potena,³ A. Solini,⁴ C. Rossi,⁴ A. Secchi,¹ D. Corradi,⁵ N. Chau,⁶ P. Fiorina.^1,2
¹Ospedale San Raffaele, Milano, Italy; ²Boston Children's Hospital, Boston; ³University of Bologna, Bologna, Italy; ⁴University of Pisa, Pisa, Italy; ⁵University of Parma, Parma, Italy; ⁶Regulus Therapeutics Inc, San Diego.
Background. Heart transplantation is the most effective therapy to prolong life expectancy in patients with end-stage heart failure. However, despite much progress in the field,…
2016 American Transplant Congress
Urine-Derived Cell Lines as a Novel Tool for Monitoring Allo-Reactivity in Kidney Transplant Patients.
C. Thieme,¹ B. Weist,¹ M. Schmück,¹ P. Reinke,¹ N. Babel.^1,2
¹Berlin-Brandenburg Center for Regenerative Therapies, University Medicine Berlin, Berlin, Germany; ²Medical Clinic I, Marien Hospital Herne, Ruhr-University Bochum, Herne, Germany.
Reactivity of the immune system against donor antigens determines transplant-rejection after transplantation, and analyzing the alloimmune response has been shown to predict acute rejection in…
2016 American Transplant Congress
High PD-L1/CD86 MFI Ratio and IL-10 Secretion Characterize Maturation-Resistant Human Regulatory Dendritic Cells (DCregs) Generated for Clinical Testing in Transplantation.
A. Zahorchak,¹ L. Butterfield,^2,3 C. Macedo,¹ D. Hamm,⁴ D. Metes,^1,3 A. Thomson.^1,3
¹Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh; ²Medicine, University of Pittsburgh, Pittsburgh; ³Immunology, University of Pittsburgh, Pittsgurgh; ⁴Adaptive Biotech, Seattle.
Regulatory dendritic cells (DCregs) have shown considerable potential for safe and effective prolongation of allograft survival in pre-clinical models. In humans, DCregs with purity >84%…
2016 American Transplant Congress
Diabetes Mellitus Predicts Outcome in Obesity After Kidney Transplantation.
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
Obesity has been associated with an increased risk of allograft loss and death from infection in kidney transplant recipients (KTRs). Therefore, previous studies suggested bariatric…
2016 American Transplant Congress
Allo-Specific Memory B Cell Recall Responses Are Dependent on B Cell Autophagy.
J. Leventhal,¹ M. Fribourg,² J. Ni,¹ P. Heeger.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; ²Neurology, Icahn School of Medicine at Mount Sinai, NY, NY.
B cells, and in particular, memory B cells (Bmem) are sources of donor specific antibodies (DSA) that cause allograft injury. Understanding requirements for Bmem function/survival…
2016 American Transplant Congress
Activation of Alloreactive T Cells by Allogeneic Exosomes and Cells Cross-Dressed with Allogeneic MHC Molecules.
M. Babiker-Mohamed, J. Marino, P. Crosby, G. Benichou.
Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital & Harvard Medical School, Boston, MA.
Our recent studies have documented the presence of high numbers of recipient antigen presenting cells (APCs) displaying donor MHC molecules (cross-dressed) on their surface after…
2016 American Transplant Congress
Fate of Endogenous Alloreactive B Cells in Transplant Tolerance.
J. Chen,¹ J. Yang,¹ A. Akl,¹ Q. Wang,¹ D. Yin,¹ R. Sciammas,² A. Chong.¹
¹Transplant Surgery, University of Chicago, Chicago, IL; ²Methodist Research Institute, Methodist Medical Center, Houston, TX.
The conceptual underpinning of our studies is that robust tolerance requires multiple mechanisms to enforce functional quiescence of alloreactive T and B cells. While much…
2016 American Transplant Congress
Vascular Endothelial Cell Activation by Mitochondria Links Innate and Adaptive Immune Responses to Allograft Injury.
F. Feng, H. Xu, L. Lin, A. Kirk, T. Brennan.
Surgery, Duke University Medical Center, Durham, NC.
Vascular endothelial cells (ECs) are an initial barrier between allografts and the host immune system and play an important role in initiating allograft rejection. Increasing…
2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
Q. Liu,¹ D. Rojas-Canales,¹ S. Divito,¹ W. Shufesky,¹ A. Larregina,² A. Morelli.¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA; ²Dermatology, University of Pittsburgh, Pittsburgh, PA.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…