Articles tagged "Allorecognition"

2016 American Transplant Congress
Vascular Endothelial Cell Activation by Mitochondria Links Innate and Adaptive Immune Responses to Allograft Injury.
F. Feng, H. Xu, L. Lin, A. Kirk, T. Brennan.
Surgery, Duke University Medical Center, Durham, NC.
Vascular endothelial cells (ECs) are an initial barrier between allografts and the host immune system and play an important role in initiating allograft rejection. Increasing…
2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
Q. Liu,¹ D. Rojas-Canales,¹ S. Divito,¹ W. Shufesky,¹ A. Larregina,² A. Morelli.¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA; ²Dermatology, University of Pittsburgh, Pittsburgh, PA.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…
2016 American Transplant Congress
Direct Alloimmunity Is Driven by Recipient APCs Displaying Donor MHC Molecules.
J. Marino,¹ J. Paster,¹ P. Crosby,¹ M. Uehara,² S. Mordecai,¹ R. Abdi,² G. Tocco,¹ G. Benichou.¹
¹Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA; ²Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA.
We have studied the trafficking of donor passenger leukocytes and donor MHC presentation in the lymphoid organs of mice having received an MHC-mismatched skin or…
2016 American Transplant Congress
mTORC2 Negatively Regulates Dendritic Cell (DC) Metabolism and the Allostimulatory Function of Donor DCs in Organ Transplantation.
A. Watson,^1,2 D. Raïche-Regué,¹ H. Dai,¹ K. Fabian,^3,4 G. Delgoffe,^4,5 W. Storkus,^3,4 A. Thomson.^1,2
¹Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh, PA; ²Pathology, Univ. of Pittsburgh, Pittsburgh, PA; ³Dermatology, Univ. of Pittsburgh, Pittsburgh, PA; ⁴Immunology, Univ. of Pittsburgh, Pittsburgh, PA; ⁵Cancer Institute, Univ. of Pittsburgh, Pittsburgh, PA.
The mechanistic target of rapamycin (mTOR) is a kinase that functions in at least two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play…
2016 American Transplant Congress
Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.
L. Margoles, S. Laurie, C. Coopersmith, M. Ford.
Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA.
Concurrent infections have been shown to increase risk of transplant rejection via enhanced innate immune activation and increased T cell alloreactivity. In some cases, these…
2016 American Transplant Congress
Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs.
M. Tonsho,¹ G. Benichou,¹ R. Yu,¹ S. Boskovic,¹ R. Colvin,^1,2 E. Farkash,² R.-N. Smith,² J. Allan,^1,4 A. Cosimi,¹ T. Kawai,^1,3 J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA; ³Department of Surgery, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
(BACKGROUND)Cardiac tolerance in nonhuman primates (NHPs) has been induced for the first time by kidney co-transplantation in combination with donor bone marrow infusion when the…
2016 American Transplant Congress
B Lymphocyte-Induced Maturation Protein-1 Promotes Allograft Survival via Modulation of T Cell Development.
A. Wang,¹ C. Loh,^1,3,4 S.-J. Chen,² C.-H. Lin,¹ H.-K. Sytwu,² S.-H. Chuang,¹ F.-C. Wei.^1,4
¹VCA; PRS Dept., CGMH, Taoyuan, Taiwan; ²Department of Microbiology and Immunology, NDMC, Taipei, Taiwan; ³Division of Surgery and Interventional Science, University College London, London, United Kingdom; ⁴College of Medicine, Chang Gung University, Taoyuan, Taiwan.
*Equal contributionPurposeVascularized composite allotransplantation (VCA) is a promising new field in plastic surgery. Skin is known to be the most immunogenic component of a composite…
2016 American Transplant Congress
Exome Sequencing and HLA-Independent Prediction of Long-Term Kidney Allograft Function.
L. Mesnard,^1,3,6 T. Muthukumar,^2,9 M. Burbach,² C. Li,² H. Shang,⁴ D. Dadhania,^2,3 J. Lee,^2,3 V. Sharma,² J. Xiang,⁴ M. Carmagnat,⁵ C. Suberbielle,⁵ N. Ouali,⁶ E. Rondeau,^6,1 J. Friedewald,⁸ M. Abecassis,⁷ M. Suthanthiran,^2,9 F. Campagne.³
¹UMR1155, INSERM, Paris, France; ²Division of Nephrology and Hypertension, New York Presbyterian Hospital, New York; ³Department of Physiology and Biophysics, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY; ⁴Genomics Core Facility, Weill Cornell Medical College, New York, NY; ⁵Laboratoire d'histocompatibilité Hôpital Saint Louis, APHP, Paris, France; ⁶Service des Urgences Néphrologiques et Transplantation Rénale, APHP, Paris, France; ⁷Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁸Northwestern University Feinberg School of Medicine, Chicago, IL; ⁹Department of Transplantation Medicine, Weill Cornell Medical College, New York, NY.
Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. We asked whether information outside of the HLA loci can…
2016 American Transplant Congress
Stratification of Kidney Transplant Recipients into Those with Low and High Alloreactive T-Cells May Allow Safe Conversion to mTOR-Inhibitor-Based Immunosuppression.
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
ZEUS and Herakles study randomized kidney transplant recipients (KTRs) to either continue cyclosporine or convert to everolimus posttransplantation with favorable long-term outcomes in the conversion…
2016 American Transplant Congress
Alloimmunity Through Non-HLA Epitopes in Kidney Transplantation.
R. Reindl-Schwaighofer,¹ A. Kainz,¹ B. Cole,² J. van Setten,² K. Jelencsics,¹ B. Keating,² R. Oberbauer.¹
¹Department of Nephrology, Medical University of Vienna, Vienna, Austria; ²Transplant Division, University of Pennsylvania, Philadelphia, PA.
Introduction: An unexpected diversity in the human genome has been identified including more than 2,500 nonsynonymous single nucleotide polymorphisms (nsSNP) and up to 20 homozygous…