Articles tagged "Allorecognition"

2016 American Transplant Congress
Immunologic Basis for Immunocloaking.
L. Brasile,¹ K. Kizjakina,¹ N. Henry,¹ B. Stubenitsky.²
¹BREONICS Inc., Watervliet, NY; ²Plastic Surgery, University of Utrecht, Utrecht, Netherlands.
A novel organ-specific immunomodifying therapy referred to as immunocloaking (IC) provides protection from early allograft rejection without immunosuppressive drugs. The IC binds to the surfaces…
2016 American Transplant Congress
The Distance Between Us: The Landscape of Recipient-Specific Loss-of-Function in Solid Organ Transplantation and Association with Rejection-Free Graft Survival.
B. Cole,^1,2,5 J. van Setten,^3,5 B. Keating.^1,4,5
¹Department of Surgery, The Penn Transplant Institute, Philadelphia, PA; ²Center for Clinical Epidemiology and Biostatistics, The Institute for Biomedical Informatics, Philadelphia, PA; ³Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands; ⁴Department of Surgery, Division of Transplant, the Children's Hospital of Philadelphia, Philadelphia, PA; ⁵The Omics Working Group, iGeneTRAiN Consortium, Philadelphia, PA.
Purpose: This study aims to comprehensively identify genes that are inactivated in both copies in transplant recipients but not in their respective donors, uncovering a…
2016 American Transplant Congress
Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.
J. Lee, G. Benichou.
Surgery, MGH/Harvard Medical School, Boston, MA.
T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…
2016 American Transplant Congress
A P2X7R Mutation with Hypermetabolic T Cells, Th1/Th17 Skewing and Reduced Cardiac Allograft Survival.
F. D'Addio,^1,2 A. Vergani,³ L. Potena,⁴ A. Maestroni,² S. Tezza,¹ M. Ben Nasr,¹ V. Usuelli,² M. Sbolli,¹ L. Borgese,⁴ A. Iacovoni,⁵ D. Corradi,⁶ R. Abdi,⁷ A. Secchi,² R. Starling,⁸ M. Sayegh,^7,9 W. Harmon,¹ D. Briscoe,¹ P. Heeger,¹⁰ A. Chandraker,⁷ F. Grigioni,⁴ P. Fiorina.^1,2
¹Boston Children's Hospital, Boston, MA; ²Ospedale San Raffaele, Milan, Italy; ³Dompe Research, Milan, Italy; ⁴University of Bologna, Bologna, Italy; ⁵Ospedale Papa Giovanni XXIII, Bergamo, Italy; ⁶University of Parma, Parma, Italy; ⁷Brigham and Women's Hospital, Boston; ⁸Cleveland Clinic, Cleveland; ⁹American University of Beirut, Lebanon, Lebanon; ¹⁰Icahn School of Medicine at Mount Sinai, New York.
Background. The purinergic receptor-7 (P2X7R), primarily expressed on lymphocytes, senses ATP released extracellularly during cell damage and regulates T cell activation.Methods. In 640 heart transplant…
2016 American Transplant Congress
Indirect Allo-Antigen Stimulation Identifies the Presence of Either Regulatory IL-10 or of Effector Cytokines IFN-g, IL-21, IL-17a Production by Human Blood Allo-Reactive Memory T_FH and T_CONV CD4⁺ T Cells.
C. Macedo, F. Paul, Y. Masaki, H. Kevin, M. Diana.
Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA.
Background: It is well accepted that human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. While our previous analysis showed…
2016 American Transplant Congress
Mechanisms of Alloantigen-Specific Regulation After Donor Specific Transfusion and Costimulatory Blockade in YFP-Foxp3/TdTomRed-Ebi3 Marker Mice.
Y. Tomita,¹ W. Bracamonte-Baran,¹ D. Vignali,² W. Burlingham.¹
¹Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI; ²Department of Immunology, University of Pittsburgh, Pittsburgh.
Background: In mice, donor specific transfusion (DST) plus anti-CD40L costimulatory blockade (MR-1) treatment is a standard and successful protocol to induced donor-specific transplant tolerance. Hypothesis:…
2016 American Transplant Congress
Rapid Emergence of CD28^null Cells Following Ex Vivo Restimulation Is Associated with Belatacept Resistant Rejection.
M. Cortes, S. Laurie, B. Sayed, M. Ford.
Emory Transplant Center, Atlanta, GA.
Numerous studies have implicated donor-reactive memory T cells in mediating costimulation blockade resistant rejection (CoBRR) following treatment with belatacept. In humans, these memory T cells…
2016 American Transplant Congress
The Presence of CMV-Specific T-Cells in CMV-Seronegative Kidney Transplant Recipients Predicts Outcome After Kidney Transplantation.
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
CMV-seronegative kidney transplant recipients (KTRs) from CMV-seropositive donors are at highly increased risk of primary CMV-infection with associated inferior outcomes after kidney transplantation. Presence of…
2016 American Transplant Congress
Exposure Analysis for the Composite Efficacy Endpoints in the US92 Phase 3 Kidney Transplantation Trial to Understand Center Effects.
F. Shihab, B. Kaplan, K. McCague, D. Patel, F. Vincenti.
University of Utah, Salt Lake City; Mayo Clinic, Phoenix; Novartis Pharmaceuticals Corporation, East Hanover; University of California, San Francisco.
The US92 study determined whether, in de novo renal transplant patients, concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®, (mycophenolate…
2016 American Transplant Congress
miR-21 in Chronic Allograft Vasculopathy.
V. Usuelli,¹ M. Ben Nasr,^1,2 F. D'Addio,^1,2 L. Kaifeng,² L. Borgese,³ L. Potena,³ A. Solini,⁴ C. Rossi,⁴ A. Secchi,¹ D. Corradi,⁵ N. Chau,⁶ P. Fiorina.^1,2
¹Ospedale San Raffaele, Milano, Italy; ²Boston Children's Hospital, Boston; ³University of Bologna, Bologna, Italy; ⁴University of Pisa, Pisa, Italy; ⁵University of Parma, Parma, Italy; ⁶Regulus Therapeutics Inc, San Diego.
Background. Heart transplantation is the most effective therapy to prolong life expectancy in patients with end-stage heart failure. However, despite much progress in the field,…