Articles tagged "Allorecognition"

2017 American Transplant Congress
Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.
T. Brennan,¹ L. Lin,¹ M. Song,¹ F. Feng,¹ Q.-J. Li,² A. Kirk,^1,2 H. Xu.¹
¹Surgery, Duke University, Durham, NC; ²Immunology, Duke University, Durham, NC
Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…
2017 American Transplant Congress
Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.
T. Borges, N. Murakami, L. Riella.
Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…
2017 American Transplant Congress
FcγRIIB-Mediated Coinhibition Attenuates Donor-Reactive CD8+ T Cell Responses.
A. Morris, D. Pinelli, D. Liu, M. Ford.
Emory Transplant Center, Emory University, Atlanta, GA
Memory T cells can be a formidable barrier to long-term, rejection-free allograft survival, particularly in the setting of costimulation blockade. Ongoing work in the field…
2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
R. Gill,¹ M. Coulombe,¹ T. Kupfer,¹ K. Beard,¹ A. Burrack.²
¹Surgery and Immunology, University of Colorado Denver, Aurora, CO; ²University of Minnesota, Minneapolis, MN
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
2017 American Transplant Congress
Nephrectomy of the Failed First Kidney Allograft Predisposes Kidney Transplant Recipients to Presensitization with Alloreactive T-Cells and Inferior Allograft Survival After Retransplantation.
T. Schachtner,^1,2 M. Stein,¹ P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany
During the last two decades the number of recipients (KTRs) of a previous kidney transplantation being evaluated and waitlisted for a subsequent kidney transplantation has…
2017 American Transplant Congress
Donor SIRPa Polymorphism Modulates the Innate Immune Response to Allogeneic Grafts.
H. Dai,¹ A. Friday,¹ K. Abou-Daya,¹ A. Williams,¹ M. Oberbarnscheidt,¹ J. Danska,² F. Lakkis.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ²Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Mice devoid of T, B, NK, and innate lymphoid cells distinguish between self and allogeneic non-self despite the absence of an adaptive immune system. When…
2017 American Transplant Congress
Donor Factors Show Low Impact on Patient and Kidney Allograft Outcomes: A Paired Analysis of Left/Right Deceased Donor Kidney Pairs.
T. Schachtner,^1,2,3 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Charite and Max-Delbrück Center, Berlin Institute of Health BIH, Berlin, Germany
The impact of donor factors on kidney allograft outcomes and infectious complications has been suggested in many previous studies. However, analyses of left/right donor kidney…
2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
B. Keating,¹ B.-L. Chang,¹ J. van Setten,² B. Cole,¹ L. Jennings,¹ G. Klintmalm,³ A. Shaked.¹
¹University of Pennsylvania, Philadelphia, PA; ²University Medical Center of Utrecht, UtrechT, Netherlands; ³Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…
2016 American Transplant Congress
B Lymphocyte-Induced Maturation Protein-1 Promotes Allograft Survival via Modulation of T Cell Development.
A. Wang,¹ C. Loh,^1,3,4 S.-J. Chen,² C.-H. Lin,¹ H.-K. Sytwu,² S.-H. Chuang,¹ F.-C. Wei.^1,4
¹VCA; PRS Dept., CGMH, Taoyuan, Taiwan; ²Department of Microbiology and Immunology, NDMC, Taipei, Taiwan; ³Division of Surgery and Interventional Science, University College London, London, United Kingdom; ⁴College of Medicine, Chang Gung University, Taoyuan, Taiwan.
*Equal contributionPurposeVascularized composite allotransplantation (VCA) is a promising new field in plastic surgery. Skin is known to be the most immunogenic component of a composite…
2016 American Transplant Congress
Exome Sequencing and HLA-Independent Prediction of Long-Term Kidney Allograft Function.
L. Mesnard,^1,3,6 T. Muthukumar,^2,9 M. Burbach,² C. Li,² H. Shang,⁴ D. Dadhania,^2,3 J. Lee,^2,3 V. Sharma,² J. Xiang,⁴ M. Carmagnat,⁵ C. Suberbielle,⁵ N. Ouali,⁶ E. Rondeau,^6,1 J. Friedewald,⁸ M. Abecassis,⁷ M. Suthanthiran,^2,9 F. Campagne.³
¹UMR1155, INSERM, Paris, France; ²Division of Nephrology and Hypertension, New York Presbyterian Hospital, New York; ³Department of Physiology and Biophysics, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY; ⁴Genomics Core Facility, Weill Cornell Medical College, New York, NY; ⁵Laboratoire d'histocompatibilité Hôpital Saint Louis, APHP, Paris, France; ⁶Service des Urgences Néphrologiques et Transplantation Rénale, APHP, Paris, France; ⁷Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁸Northwestern University Feinberg School of Medicine, Chicago, IL; ⁹Department of Transplantation Medicine, Weill Cornell Medical College, New York, NY.
Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. We asked whether information outside of the HLA loci can…