- 2017 American Transplant Congress - Rapamycin Directly Alters Human Endothelial Cell Alloimmunogenicity.The mTOR inhibitor rapamycin (Rapa) is known to suppress T cell function. However, many of its in vivo effects, particularly its synergistic effects with costimulation…
- 2017 American Transplant Congress - Exosomes Containing IL35 Are Secreted by Donor-Specific Regulatory T Cells and Cause Linked-Suppression.Introduction: We previously reported that donor specific splenocytes transfusion (DST) plus anti-CD40L costimulatory blockade treatment causes allo-specific regulation approximately 5 weeks after the tolerization. The…
- 2017 American Transplant Congress - Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity.- Emory Transplant Center, Emory University, Atlanta, GA Recipient-derived, graft-specific memory T cells play a critical role in mediating allograft rejection, particularly in the setting of immunosuppression with costimulation blockade. Recently, it is…
- 2017 American Transplant Congress - Refinement of an Old Faithful: A Standardized Flow Cytometry Approach to Measure Donor-Recipient Alloreactivity (a Pilot Study).Purpose: Donor-specific antibody (DSA) and antibody (Ab)-mediated rejection are challenges in long-term outcomes and limit re-transplantation. Sensitizing events such as homografts in surgical procedures, assist…
- 2017 American Transplant Congress - Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.- 1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…
- 2017 American Transplant Congress - Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…
- 2017 American Transplant Congress - FcγRIIB-Mediated Coinhibition Attenuates Donor-Reactive CD8+ T Cell Responses.- Emory Transplant Center, Emory University, Atlanta, GA Memory T cells can be a formidable barrier to long-term, rejection-free allograft survival, particularly in the setting of costimulation blockade. Ongoing work in the field…
- 2017 American Transplant Congress - Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
- 2016 American Transplant Congress - Activation of Alloreactive T Cells by Allogeneic Exosomes and Cells Cross-Dressed with Allogeneic MHC Molecules.Our recent studies have documented the presence of high numbers of recipient antigen presenting cells (APCs) displaying donor MHC molecules (cross-dressed) on their surface after…
- 2016 American Transplant Congress - Fate of Endogenous Alloreactive B Cells in Transplant Tolerance.The conceptual underpinning of our studies is that robust tolerance requires multiple mechanisms to enforce functional quiescence of alloreactive T and B cells. While much…
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