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American Transplant Congress abstracts

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Articles tagged "Allorecognition"

  • 2017 American Transplant Congress

    Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.

    T. Brennan,1 F. Feng,1 L. Lin,1 M. Song,1 Q.-J. Li,2 A. Kirk,1,2 H. Xu.1

    1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC

    Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…
  • 2017 American Transplant Congress

    Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.

    B. Gonzalez-Nolasco, J. Marino, W. Orent, G. Benichou.

    Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA

    Background:CD8+ memory T cells produce IFN-g in a faster and stronger fashion than their naïve counterparts after allorecognition. Unmanipulated mice possess a proportion of endogenous…
  • 2017 American Transplant Congress

    mTOR Inhibition Diminishes Peripheral Blood CD8+CD28–CD38hi Effector/Memory T Cells and Facilitates Resolution of Belatacept-Refractory Kidney Rejection.

    C. Castro-Rojas,1 A. Godarova,1 A. Leino,2 R. Alloway,2 M. Jordan,3 E. Woodle,2 D. Hildeman.1

    1Division of Immunobiology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH; 2Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH; 3Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Research Foundation, Cincinnati, OH

    Belatacept, a CD28-CD80/86 blocker, was approved by the FDA to provide immunosuppression without nephrotoxicity or cardiovascular and metabolic adverse effects. As part of our multi-center…
  • 2017 American Transplant Congress

    Trafficking of Donor Leukocytes and Recipient Cells Cross-Dressed with Donor MHC Molecules After Transplantation of Cardiac Allografts in Monkeys.

    J. Marino, K. Robinson, J. Paster, I. Hanekamp, J. Madsen, G. Benichou.

    Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA

    Activation of recipient T cells recognizing allogeneic MHC molecules displayed on donor leukocytes is known to trigger acute allograft rejection (direct allorecognition). Recently, we have…
  • 2017 American Transplant Congress

    Genome-Wide Genotyping in 1022 Heart Transplantation Recipients & 758 Donors Reveal Association with Acute Allograft Rejection.

    J. van Setten,1 B. Cole,2 B. Chang,2 N. de Jonge,1 M. Holmes,2 C. Baan,4 O. Manintveld,4 A. Peeters,4 F. Dominguez,5 K. Khush,3 P. Garcia-Pavia,5 M. Huibers,1 R. de Weger,1 J. Moore,2 F. Asselbergs,1 B. Keating.2

    1UMC Utrecht, Utrecht, Netherlands; 2University of Pennsylvania, Philadelphia; 3Stanford University, Stanford, CA; 4Erasmus MC, Rotterdam, Netherlands; 5Puerta de Hierro University Hospital, Madrid, Spain

    Introduction: Acute rejection (AR) in the 1st year post-cardiac transplant remains a significant clinical issue, and predisposes recipients to subsequent chronic allograft vasculopathy. Genetic factors…
  • 2017 American Transplant Congress

    Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.

    J. Merola, C. Anderson, H. Xu, T. Manes, J. Pober.

    Yale School of Medicine, New Haven, CT

    Human endothelial cells (ECs) derived from cord blood progenitors have significant replicative potential and are thus well suited for use in tissue engineering of vascularized…
  • 2017 American Transplant Congress

    Accelerated Rejection of Secondary Third Party Allografts in Older Recipients Is Facilitated by an Augmented Innate Immune Response.

    T. Heinbokel, K. Minami, A. Elkhal, S. Tullius.

    Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Accumulating evidence acknowledges the central relevance of aging and chronic antigen exposure in shaping the balance of innate and adaptive immunity. Here, we assessed whether…
  • 2017 American Transplant Congress

    Placental Leukocytes Are Maternally Derived: Implications for Pregnancy-Induced Alloimmunization.

    P. Porrett,1 E. Lewis,2 R. Xu,1 A. Brown,2 E. Wherry,3 M. Elovitz.2

    1Surgery, University of Pennyslvania, Philadelphia, PA; 2Obstetrics & Gynecology, University of Pennsylvania, Philadelphia, PA; 3Microbiology, University of Pennsylvania, Philadelphia, PA

    Background Alloimmunization of women during pregnancy has significant consequences for both transplant access and outcomes. However, the location and context of maternal immune priming by…
  • 2016 American Transplant Congress

    Malignancies Contribute to Presensitization with Alloreactive T-Cells in Kidney Transplant Recipients.

    T. Schachtner,1,2 M. Stein,2 P. Reinke.1,2

    1Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; 2Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.

    Alloreactive T-cells have been suggested to impact allograft outcome due to a higher incidence of acute rejection in the initial period after kidney transplantation. Knowledge…
  • 2016 American Transplant Congress

    An In-Situ Treatment of Donor Skin Induces MARCH1 and Decreases MHC II Expression on Donor Dendritic Cells, Promoting Skin Allograft Acceptance.

    T. Borges,1,2 F. Machado,1 C. Bonorino,1 L. Riella.2

    1School of Biosciences and Biomedical Research Institute, PUCRS, Porto Alegre, RS, Brazil; 2Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

    Background: Skin transplants are the most immunogenic of all transplants and donor DCs play a crucial role in activating effector alloreactive T cells and initiating…
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