2017 American Transplant Congress
Donor Factors Show Low Impact on Patient and Kidney Allograft Outcomes: A Paired Analysis of Left/Right Deceased Donor Kidney Pairs.
The impact of donor factors on kidney allograft outcomes and infectious complications has been suggested in many previous studies. However, analyses of left/right donor kidney…2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…2017 American Transplant Congress
Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.
1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC
Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…2017 American Transplant Congress
Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.
Background:CD8+ memory T cells produce IFN-g in a faster and stronger fashion than their naïve counterparts after allorecognition. Unmanipulated mice possess a proportion of endogenous…2017 American Transplant Congress
mTOR Inhibition Diminishes Peripheral Blood CD8+CD28–CD38hi Effector/Memory T Cells and Facilitates Resolution of Belatacept-Refractory Kidney Rejection.
Belatacept, a CD28-CD80/86 blocker, was approved by the FDA to provide immunosuppression without nephrotoxicity or cardiovascular and metabolic adverse effects. As part of our multi-center…2017 American Transplant Congress
Trafficking of Donor Leukocytes and Recipient Cells Cross-Dressed with Donor MHC Molecules After Transplantation of Cardiac Allografts in Monkeys.
Activation of recipient T cells recognizing allogeneic MHC molecules displayed on donor leukocytes is known to trigger acute allograft rejection (direct allorecognition). Recently, we have…2017 American Transplant Congress
Genome-Wide Genotyping in 1022 Heart Transplantation Recipients & 758 Donors Reveal Association with Acute Allograft Rejection.
Introduction: Acute rejection (AR) in the 1st year post-cardiac transplant remains a significant clinical issue, and predisposes recipients to subsequent chronic allograft vasculopathy. Genetic factors…2017 American Transplant Congress
Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.
Yale School of Medicine, New Haven, CT
Human endothelial cells (ECs) derived from cord blood progenitors have significant replicative potential and are thus well suited for use in tissue engineering of vascularized…2017 American Transplant Congress
Accelerated Rejection of Secondary Third Party Allografts in Older Recipients Is Facilitated by an Augmented Innate Immune Response.
Accumulating evidence acknowledges the central relevance of aging and chronic antigen exposure in shaping the balance of innate and adaptive immunity. Here, we assessed whether…2017 American Transplant Congress
Placental Leukocytes Are Maternally Derived: Implications for Pregnancy-Induced Alloimmunization.
Background Alloimmunization of women during pregnancy has significant consequences for both transplant access and outcomes. However, the location and context of maternal immune priming by…
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