2017 American Transplant Congress
Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity.
Emory Transplant Center, Emory University, Atlanta, GA
Recipient-derived, graft-specific memory T cells play a critical role in mediating allograft rejection, particularly in the setting of immunosuppression with costimulation blockade. Recently, it is…2017 American Transplant Congress
Refinement of an Old Faithful: A Standardized Flow Cytometry Approach to Measure Donor-Recipient Alloreactivity (a Pilot Study).
Purpose: Donor-specific antibody (DSA) and antibody (Ab)-mediated rejection are challenges in long-term outcomes and limit re-transplantation. Sensitizing events such as homografts in surgical procedures, assist…2017 American Transplant Congress
Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.
1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC
Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…2017 American Transplant Congress
Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.
Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…2017 American Transplant Congress
FcγRIIB-Mediated Coinhibition Attenuates Donor-Reactive CD8+ T Cell Responses.
Emory Transplant Center, Emory University, Atlanta, GA
Memory T cells can be a formidable barrier to long-term, rejection-free allograft survival, particularly in the setting of costimulation blockade. Ongoing work in the field…2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…2017 American Transplant Congress
Nephrectomy of the Failed First Kidney Allograft Predisposes Kidney Transplant Recipients to Presensitization with Alloreactive T-Cells and Inferior Allograft Survival After Retransplantation.
During the last two decades the number of recipients (KTRs) of a previous kidney transplantation being evaluated and waitlisted for a subsequent kidney transplantation has…2017 American Transplant Congress
Donor SIRPa Polymorphism Modulates the Innate Immune Response to Allogeneic Grafts.
Mice devoid of T, B, NK, and innate lymphoid cells distinguish between self and allogeneic non-self despite the absence of an adaptive immune system. When…2017 American Transplant Congress
Donor Factors Show Low Impact on Patient and Kidney Allograft Outcomes: A Paired Analysis of Left/Right Deceased Donor Kidney Pairs.
The impact of donor factors on kidney allograft outcomes and infectious complications has been suggested in many previous studies. However, analyses of left/right donor kidney…2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…
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