2018 American Transplant Congress
Regulatory Dendritic Cell (DCreg) Cell Infusion in Living Donor Liver Transplantation
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Purpose: We have embarked on a first-in-human phase I/II safety and preliminary efficacy trial of donor-derived regulatory dendritic cells (DCreg) in living donor liver transplantation…2017 American Transplant Congress
Expression of T-Cell Mediated Rejection (TCMR) Associated Genes in Native and Renal Allograft Renal Biopsies with Inflamed Scars (i-IFTA).
The presence of i-IFTA in allograft kidney biopsies is a bad prognostic parameter. However, despite the presence of T-cell infiltrates in these lesions there is…2017 American Transplant Congress
IL-21R Antagonist Inhibits Differentiation of B Cells Towards Plasmablasts upon Alloantigen Stimulation.
Background: Antigen-specific antibody responses rely on IL-21+ T follicular helper (Tfh) cells that regulate B cell differentiation. In transplantation, a large proportion of renal allograft…2017 American Transplant Congress
Inhibition of Heat Shock Protein 90 Suppresses the Expression of MHC Class I Molecules, but Not MHC Class II Molecules, on Endothelial Cells in Allografts.
Urology, Sapporo Medical University, Sapporo, Japan
Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…2017 American Transplant Congress
Non-Human Primate Auto-Immune Responses to Col V, Kα-1Tubulin and Vimentin Are P2X7R Dependent.
1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI
Background: Auto-immune responses to Collagen type V (ColV) have been associated with coronary artery disease and lung or heart transplant rejection in humans and murine…2017 American Transplant Congress
Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.
Yale School of Medicine, New Haven, CT
Human endothelial cells (ECs) derived from cord blood progenitors have significant replicative potential and are thus well suited for use in tissue engineering of vascularized…2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts).
Background: Ab-mediated rejection (ABMR) is a major obstacle in HS KTx Pts. ADCC is a mechanism responsible for ABMR. IdeS cleaves all 4 human IgG…2017 American Transplant Congress
C4d Immunohistochemistry in Lung Allograft Interstitial Capillaries Lacks Linear Correlation with Donor Specific Antibodies, yet It Is Still Diagnostically Relevant.
Antibody mediated rejection in lung allograft biopsies is not well defined from a morphologic or immunohistochemical aspect. Many centers routinely run immunohistochemistry for C4d as…2017 American Transplant Congress
Transient High Dose Tacrolimus Allows Tolerance of a Vascularized Composite Allograft Tolerance Across a Full MHC Mismatch.
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD
Purpose: The achievement of tolerance in Vascularized composite allografts (VCA) could avoid the risks of immunosuppression in this setting. We investigated strategies for tolerance induction…2017 American Transplant Congress
IL-33 Enhances the Ability of Dendritic Cells to Expand Human Regulatory T Cells.
Introduction:The importance of increasing the number of regulatory T cells (Treg) relative to T effectors for the promotion of long-term experimental allograft survival/tolerance is well-established.…
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