Articles tagged "Alloantigens"

2022 American Transplant Congress
HLA-II Subclasses Behave Differently Between Themselves and Between Humans: Cues to Understand Alloreactivity
S. Beland, O. Desy, M. Marcoux, M. Thivierge, J. Desgagnes, S. A. De Serres
Transplantation Unit, Renal Division, University Health Center of Quebec, Faculty of Medicine, Universite Laval, Quebec, QC, Canada
*Purpose: De novo anti-HLA-II DSAs (dnDSA) are associated with antibody-mediated rejection. However, some patients with anti-HLA-II DSAs will not develop rejection, suggesting that the development…
2022 American Transplant Congress
Alloimmunization Against Red Blood Cell Antigens is Not Associated with Increased All Cause Mortality in Liver Transplant Recipients
Y. Chornenkyy¹, A. P. Gama¹, N. Khurram¹, A. L. Booth¹, J. R. Leventhal², G. E. Ramsey¹, G. Yang¹
¹Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Liver transplantation (LT) is a life‐saving procedure for patients with end‐stage liver disease and transfusion therapy of LT patients remains a challenge. Improvement of…
2022 American Transplant Congress
“ABO-Adjusted CPRA”: A Unified Metric for Immunologic Compatibility in Kidney Transplantation
L. Gragert¹, M. Kadatz², J. Alcorn³, D. Stewart³, D. Chang², J. Gill², R. Liwski⁴, H. Gebel⁵, E. Kransdorf⁶, J. Gill², J. Lan²
¹Tulane University, New Orleans, LA, ²University of British Columbia, Vancouver, BC, Canada, ³UNOS, Richmond, VA, ⁴Dalhousie University, Halifax, NS, Canada, ⁵Emory University, Atlanta, GA, ⁶Cedars-Sinai, Beverly Hills, CA
*Purpose: Implementation of the kidney allocation system in 2014 greatly reduced access disparity due to HLA sensitization. To address persistent disparities among both candidate cPRA…
2021 American Transplant Congress
Epigenetic & Functional Changes Associated with Alloreactive Memory CD8 T Cell Subsets in Liver Transplant Patients
H. Abdelsamed¹, S. Liu¹, M. Juya¹, D. Metes², F. Lakkis¹, A. Thomson¹
¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²UPMC, Pittsburgh, PA
*Purpose: Donor-specific allo-reactive memory CD8 T cells play a pivotal role in allo-immunity and represent a major hurdle against tolerance induction in solid organ transplantation.…
2021 American Transplant Congress
Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome
K. Janek¹, J. H. Fechner¹, R. A. Daley¹, K. Krautkamer¹, F. Rey², J. D. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine & Public Health, Madison, WI, ²Bacteriology, University of Wisconsin, Madison, WI
*Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…
2021 American Transplant Congress
Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone
P. A. Fontes
NA, LyGenesis, Pittsburgh, PA
*Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…
2021 American Transplant Congress
Iguratimod Reduce Panel Reactive Antibody in High Mismatched Renal Transplant Recipients: A Retrospective Propensity Score-Matched Study
D. Feng, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: To evaluate the clinical efficacy and safety of iguratimod (IGU) for reducing panel reactive antibody (PRA) in high mismatched renal transplant recipients.*Methods: Eligible recipients…
2021 American Transplant Congress
hlaR,” a Simplified Interface for the HLA Matchmaker Tool
A. Johnson¹, J. Zhang¹, H. Gebel², C. Larsen¹
¹Surgery, Emory University, Atlanta, GA, ²Pathology, Emory University, Atlanta, GA
*Purpose: Functional epitopes, or eplets, represent a set of amino acids within three angstroms of one another that may not be sequentially contiguous but are…
2020 American Transplant Congress
The Addition of Splenectomy to Simultaneous Liver Kidney Transplantation Improves Class II DSA Clearance in Sensitized Patients
V. Fleetwood, D. Aufhauser, C. Papageorge, K. Janek, L. Hidalgo, B. Welch, R. Redfield, J. Mezrich
Department of Transplantation, University of Wisconsin, Madison, WI
*Purpose: The liver allograft clears class I donor specific antibody (DSA) more effectively than class II DSA. Persistent class II DSA in simultaneous liver kidney…
2020 American Transplant Congress
Risk Factors for Antibody-Mediated Rejection after Adult Liver Transplantation with Preformed Donor-Specific Antibodies: A Single Center Experience
T. Tajima, K. Hata, J. Kusakabe, H. Miyauchi, T. Anazawa, T. Ito, S. Uemoto
Div. of HBP Surgery and Transplantation, Dept. of Surgery, Kyoto University, Kyoto, Japan
*Purpose: In general, preformed donor-specific antibodies (pDSAs) can lead to an increased risk of antibody-mediated rejection (AMR); however, their prevalence, risk factors, and the efficacy…