2022 American Transplant Congress
Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance
*Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…2022 American Transplant Congress
Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens
*Purpose: Highly sensitised (HS) patients exhibit worse long-term outcomes after kidney transplantation compared to non-sensitised patients. It has been hypothesised that regulatory T cells (Tregs)…2022 American Transplant Congress
Regulatory T Cells Suppress Memory IFN-Gamma Production in Highly Sensitised Patients
*Purpose: Highly sensitized patients (HS) present worse long-term outcome after transplantation compared to those without donor-specific antibodies (DSA). It has been suggested that desensitisation using…2021 American Transplant Congress
hlaR,” a Simplified Interface for the HLA Matchmaker Tool
1Surgery, Emory University, Atlanta, GA, 2Pathology, Emory University, Atlanta, GA
*Purpose: Functional epitopes, or eplets, represent a set of amino acids within three angstroms of one another that may not be sequentially contiguous but are…2021 American Transplant Congress
Epigenetic & Functional Changes Associated with Alloreactive Memory CD8 T Cell Subsets in Liver Transplant Patients
1University of Pittsburgh Medical Center, Pittsburgh, PA, 2UPMC, Pittsburgh, PA
*Purpose: Donor-specific allo-reactive memory CD8 T cells play a pivotal role in allo-immunity and represent a major hurdle against tolerance induction in solid organ transplantation.…2021 American Transplant Congress
Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome
*Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…2021 American Transplant Congress
Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone
*Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…2021 American Transplant Congress
Iguratimod Reduce Panel Reactive Antibody in High Mismatched Renal Transplant Recipients: A Retrospective Propensity Score-Matched Study
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: To evaluate the clinical efficacy and safety of iguratimod (IGU) for reducing panel reactive antibody (PRA) in high mismatched renal transplant recipients.*Methods: Eligible recipients…2020 American Transplant Congress
Activated CD27+CD21– Subset Dominate the Memory B Cell Response During Antibody-Mediated Rejection of Kidney Allografts
1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Inserm UMR 976, Paris, France
*Purpose: The role of alloreactive memory B (mB) cells in the pathogenesis of antibody-mediated rejection (ABMR) is increasingly recognized. Yet, a comprehensive characterization of mB…2020 American Transplant Congress
The Addition of Splenectomy to Simultaneous Liver Kidney Transplantation Improves Class II DSA Clearance in Sensitized Patients
Department of Transplantation, University of Wisconsin, Madison, WI
*Purpose: The liver allograft clears class I donor specific antibody (DSA) more effectively than class II DSA. Persistent class II DSA in simultaneous liver kidney…
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