ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Alloantigens"

  • 2022 American Transplant Congress

    cDC1-Mediated Prolongation of Cardiac Allograft Survival and Alloantigen Induced Transcriptional Programming

    S. L. Schroth, E. B. Thorp

    Pathology, Northwestern Feinberg School of Medicine, Chicago, IL

    *Purpose: Heart transplantation is currently the only treatment for advanced stage heart failure. While patient survival after transplantation has improved acutely, the same cannot be…
  • 2022 American Transplant Congress

    Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential

    U. Bhatia, E. C. Guinan

    Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA

    *Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…
  • 2022 American Transplant Congress

    Impact of the High Baseline Anti-a/b Antibody Titer on the Clinical Outcomes in ABO-incompatible Living Donor Liver Transplantation

    J. Cho, B. Lee, H. Lee

    Surgery, Seoul National Bundang Hospital, Seongnam, Korea, Republic of

    *Purpose: Recently, advances in desensitization protocol have made ABO-incompatible (ABOi) living donor liver transplantation (LDLT) feasible option in the era of organ shortage. Although, multiple…
  • 2021 American Transplant Congress

    Epigenetic & Functional Changes Associated with Alloreactive Memory CD8 T Cell Subsets in Liver Transplant Patients

    H. Abdelsamed1, S. Liu1, M. Juya1, D. Metes2, F. Lakkis1, A. Thomson1

    1University of Pittsburgh Medical Center, Pittsburgh, PA, 2UPMC, Pittsburgh, PA

    *Purpose: Donor-specific allo-reactive memory CD8 T cells play a pivotal role in allo-immunity and represent a major hurdle against tolerance induction in solid organ transplantation.…
  • 2021 American Transplant Congress

    Environmental Factors That Shape T-cell Alloimmunity: Role of the Microbiome

    K. Janek1, J. H. Fechner1, R. A. Daley1, K. Krautkamer1, F. Rey2, J. D. Mezrich1

    1Surgery, University of Wisconsin School of Medicine & Public Health, Madison, WI, 2Bacteriology, University of Wisconsin, Madison, WI

    *Purpose: Unlike other types of immunity, T-cell alloimmune responses to mismatched MHC proteins do not need priming by a previous exposure. While genetic differences between…
  • 2021 American Transplant Congress

    Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone

    P. A. Fontes

    NA, LyGenesis, Pittsburgh, PA

    *Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…
  • 2021 American Transplant Congress

    Iguratimod Reduce Panel Reactive Antibody in High Mismatched Renal Transplant Recipients: A Retrospective Propensity Score-Matched Study

    D. Feng, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: To evaluate the clinical efficacy and safety of iguratimod (IGU) for reducing panel reactive antibody (PRA) in high mismatched renal transplant recipients.*Methods: Eligible recipients…
  • 2021 American Transplant Congress

    hlaR,” a Simplified Interface for the HLA Matchmaker Tool

    A. Johnson1, J. Zhang1, H. Gebel2, C. Larsen1

    1Surgery, Emory University, Atlanta, GA, 2Pathology, Emory University, Atlanta, GA

    *Purpose: Functional epitopes, or eplets, represent a set of amino acids within three angstroms of one another that may not be sequentially contiguous but are…
  • 2020 American Transplant Congress

    Human, Monkey Transplant Tolerance and IL35 “Exokine

    W. J. Burlingham1, E. Jankowska-Gan2, D. Lema2, J. H. Fechner2, J. A. Sullivan2, D. B. Kaufman2

    1University of Wisconsin, Madison, WI, 2Surgery, University of Wisconsin, Madison, WI

    *Purpose: Studies in B6 (H2b) mice tolerized to CBA (H2k) have shown that induced allospecific Tregs make 2 very different forms of immunoregulatory cytokines: 1)…
  • 2020 American Transplant Congress

    The Potential Significance of ABO Genotyping for Donor Selection in Kidney Transplantation

    Y. Zhou1, W. Deng1, Y. Wang1, N. Cui1, Y. Wu1, J. Xu1, S. Fu1, L. Xiao1, H. Liu1, F. Xiong2, Y. Miao1

    1Department of Organ Trasplantation, Nanfang Hospital, Guangzhou, China, 2Southern Medical University, Guangzhou, China

    *Purpose: The ABO blood group system is clinically important in kidney transplantation, but ABO genotyping fails to attract sufficient attention in China. We identified one…
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