2022 American Transplant Congress
Optimal Development and Effector Function of Antibody-Suppressor CXCR5+CD8+ T Cells Requires Host IFN-γ and CD4+ T Cells
*Purpose: We reported the discovery of a novel subset of CXCR5+IFNγ+CD8+ T cells that suppresses antibody production (CD8+ TAb-supp cells). Alloprimed CD8+ TAb-supp cells significantly…2022 American Transplant Congress
Marginal Zone Phenotype B Cells Are Required for Formation of Donor-Specific IgG After Allogeneic Sensitization
Department of Pathology, Johns Hopkins University, Baltimore, MD
*Purpose: The formation of allogeneic antibody directed against non-self MHC, termed donor-specific antibody (DSA), is a significant barrier to successful transplant outcomes. Pre-formed DSA limits…2022 American Transplant Congress
Alloprimed Antibody-Suppressor CD8+ T Cells Preferentially Kill Alloprimed Germinal Center B Cells
*Purpose: Antibody-mediated rejection (AMR) is a significant contributor to transplant rejection. Our prior work identified a novel subset of CXCR5+CD8+ T cells (CD8+ TAb-supp cells)…2022 American Transplant Congress
Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance
*Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…2022 American Transplant Congress
Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens
*Purpose: Highly sensitised (HS) patients exhibit worse long-term outcomes after kidney transplantation compared to non-sensitised patients. It has been hypothesised that regulatory T cells (Tregs)…2022 American Transplant Congress
Regulatory T Cells Suppress Memory IFN-Gamma Production in Highly Sensitised Patients
*Purpose: Highly sensitized patients (HS) present worse long-term outcome after transplantation compared to those without donor-specific antibodies (DSA). It has been suggested that desensitisation using…2022 American Transplant Congress
HLA-II Subclasses Behave Differently Between Themselves and Between Humans: Cues to Understand Alloreactivity
*Purpose: De novo anti-HLA-II DSAs (dnDSA) are associated with antibody-mediated rejection. However, some patients with anti-HLA-II DSAs will not develop rejection, suggesting that the development…2022 American Transplant Congress
Alloimmunization Against Red Blood Cell Antigens is Not Associated with Increased All Cause Mortality in Liver Transplant Recipients
*Purpose: Liver transplantation (LT) is a life‐saving procedure for patients with end‐stage liver disease and transfusion therapy of LT patients remains a challenge. Improvement of…2022 American Transplant Congress
“ABO-Adjusted CPRA”: A Unified Metric for Immunologic Compatibility in Kidney Transplantation
*Purpose: Implementation of the kidney allocation system in 2014 greatly reduced access disparity due to HLA sensitization. To address persistent disparities among both candidate cPRA…2022 American Transplant Congress
Fibroblastic Reticular Cell Subset Transcriptional Reprogramming Differs in Response to Immunity versus Tolerance
1UMB, Baltimore, MD, 2Harvard University, Boston, MD
*Purpose: Lymph node (LN) fibroblastic reticular cells (FRCs) are central contributors to the LN niche. We hypothesized that FRC subsets reactive to immunity versus tolerance…
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