2022 American Transplant Congress
Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens
*Purpose: Highly sensitised (HS) patients exhibit worse long-term outcomes after kidney transplantation compared to non-sensitised patients. It has been hypothesised that regulatory T cells (Tregs)…2022 American Transplant Congress
Regulatory T Cells Suppress Memory IFN-Gamma Production in Highly Sensitised Patients
*Purpose: Highly sensitized patients (HS) present worse long-term outcome after transplantation compared to those without donor-specific antibodies (DSA). It has been suggested that desensitisation using…2022 American Transplant Congress
HLA-II Subclasses Behave Differently Between Themselves and Between Humans: Cues to Understand Alloreactivity
*Purpose: De novo anti-HLA-II DSAs (dnDSA) are associated with antibody-mediated rejection. However, some patients with anti-HLA-II DSAs will not develop rejection, suggesting that the development…2022 American Transplant Congress
Alloimmunization Against Red Blood Cell Antigens is Not Associated with Increased All Cause Mortality in Liver Transplant Recipients
*Purpose: Liver transplantation (LT) is a life‐saving procedure for patients with end‐stage liver disease and transfusion therapy of LT patients remains a challenge. Improvement of…2022 American Transplant Congress
“ABO-Adjusted CPRA”: A Unified Metric for Immunologic Compatibility in Kidney Transplantation
*Purpose: Implementation of the kidney allocation system in 2014 greatly reduced access disparity due to HLA sensitization. To address persistent disparities among both candidate cPRA…2022 American Transplant Congress
Fibroblastic Reticular Cell Subset Transcriptional Reprogramming Differs in Response to Immunity versus Tolerance
1UMB, Baltimore, MD, 2Harvard University, Boston, MD
*Purpose: Lymph node (LN) fibroblastic reticular cells (FRCs) are central contributors to the LN niche. We hypothesized that FRC subsets reactive to immunity versus tolerance…2022 American Transplant Congress
cDC1-Mediated Prolongation of Cardiac Allograft Survival and Alloantigen Induced Transcriptional Programming
Pathology, Northwestern Feinberg School of Medicine, Chicago, IL
*Purpose: Heart transplantation is currently the only treatment for advanced stage heart failure. While patient survival after transplantation has improved acutely, the same cannot be…2022 American Transplant Congress
Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…2022 American Transplant Congress
Impact of the High Baseline Anti-a/b Antibody Titer on the Clinical Outcomes in ABO-incompatible Living Donor Liver Transplantation
Surgery, Seoul National Bundang Hospital, Seongnam, Korea, Republic of
*Purpose: Recently, advances in desensitization protocol have made ABO-incompatible (ABOi) living donor liver transplantation (LDLT) feasible option in the era of organ shortage. Although, multiple…2022 American Transplant Congress
Optimal Development and Effector Function of Antibody-Suppressor CXCR5+CD8+ T Cells Requires Host IFN-γ and CD4+ T Cells
*Purpose: We reported the discovery of a novel subset of CXCR5+IFNγ+CD8+ T cells that suppresses antibody production (CD8+ TAb-supp cells). Alloprimed CD8+ TAb-supp cells significantly…
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