2020 American Transplant Congress
Transitional B Cell Cytokines for the Early Prediction of Long-Term Renal Allograft Decline
1Starzl Transplantation Institute, UPMC, Pittsburgh, PA, 2UCL, London, London, United Kingdom
*Purpose: Early prediction of allograft loss using potentially modifiable risk factors is vital for conceiving novel therapeutic interventions to improve outcomes.*Methods: In this prospective, multicenter…2020 American Transplant Congress
Immune Response Following Cardiac Progenitor Cells Transplantation in Rat Myocardial Infarction Model
Surgery, University of Maryland, Baltimore, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo…2020 American Transplant Congress
The Impact of HLA-DQ Molecular Mismatches on De Novo Occurrence of Donor-Specific Anti-HLA Antibodies after Kidney Transplantation: An Observational Cohort Study
*Purpose: Evaluating HLA molecular mismatches (MM) instead of antigen mismatches might be a better tool to assess donor-recipient HLA incompatibility and provide a better risk…2020 American Transplant Congress
Serum CXCL13 Levels Indicate Humoral Alloreactivity and Donor Specific Antibody Formation
*Purpose: Donor-specific antibodies (DSA) are an increasingly recognized cause of allograft injury, yet biomarkers to predict their development or guide their clinical management post-transplant are…2020 American Transplant Congress
Erythropoietin Reduces Alloantibody Formation by Inhibiting T Follicular Helper Cells
*Purpose: Donor-specific antibodies (DSA) develop in a significant minority of transplant recipients and are associated with increased morbidity and mortality, underscoring the need to identify…2020 American Transplant Congress
Calculated Panel Reactive Antibody Values Increase for Kidney Transplant Candidates with HLA-DQA and HLA-DPB Unacceptable Antigens
*Purpose: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. CPRA includes…2020 American Transplant Congress
Are Molecular Diagnoses of Antibody Mediated Rejection (ABMR) Reliable in the Setting of Antibody-Antigen Complex Mediated Tissue Injury Unrelated to Alloimmunity?
*Purpose: Transcriptomics based tests for ABMR are now available commercially. The reliability of these tests in clinical settings where allograft tissue is damaged by antibody-antigen…2020 American Transplant Congress
HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bethiB Cell Response to Vaccine
University of Alabama, Birmingham, AL
*Purpose: Bystander B cell differentiation into antibody (Ab) secreting cells (ASCs) may augment alloimmunity in the HLA-sensitized patient. Recently, a population of FcrL5+IgDnegB cells that…2020 American Transplant Congress
Role of B-Cell Subsets in Allograft Rejection in Intestinal Transplantation
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: While B-cells contribute to allograft rejection by presenting antigens to T-cells and by producing donor-specific antibodies (DSAs) and various cytokines, their pathophysiology in transplant…2020 American Transplant Congress
Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Rejection – Molecular Rebound Phenomena Under IL-6 Blockade?
*Purpose: Late antibody-mediated rejection (ABMR) is well established as a major cause of kidney allograft failure. Targeting interleukin-6 (IL-6), a pro-inflammatory cytokine involved in B…
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