Articles tagged "Alloantibodies"

2021 American Transplant Congress
Acoustofluidic Device to Remove Donor Specific Antibody in a Sensitized Animal Model
J. Kwun¹, E. David², Y. Gu³, Z. Ma³, M. Kuchibhatla⁴, G. Arepally⁵, T. J. Huang³, E. T. Chambers²
¹Surgery, Duke University, Durham, NC, ²Pediatrics, Duke University, Durham, NC, ³Biomedical Engineering, Duke University, Durham, NC, ⁴Biostatistics and Bioinformatics, Duke University, Durham, NC, ⁵Internal Medicine, Duke University, Durham, NC
*Purpose: Current therapies for antibody-mediated rejection are neither donor-specific nor are they tailored toward children, resulting in premature allograft loss and increased mortality. Apheresis involves…
2021 American Transplant Congress
The Absence of T Follicular Regulatory Cells Prolongs Germinal Center Reactivity in Transplantation
E. S. Crichton, S. Zeng, I. Badell
Emory University, Atlanta, GA
*Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…
2021 American Transplant Congress
Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies
R. G. Gill¹, B. Mehrad², C. M. Lin²
¹Surgery, University of Colorado Denver, Aurora, CO, ²Medicine, University of Florida, Gainesville, FL
*Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…
2021 American Transplant Congress
Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation
S. Zeng, E. S. Crichton, I. R. Badell
Department of Surgery, Emory, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…
2021 American Transplant Congress
Use of a Novel Bead-based Assay to Measure the Impact of Imlifidase on ABO IgG Antibodies
A. Halpin¹, B. Motyka², T. Ellis², J. Pearcey², T. L. Lowary³, A. Runström⁴, L. Winstedt⁴, R. Bockermann⁴, S. Järnum⁴, A. Robertson⁴, L. J. West⁵
¹Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta and Alberta Precision Laboratories, Edmonton, AB, Canada, ²Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ⁴Hansa Biopharma, Lund, Sweden, ⁵Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: The accurate assessment and measurement of ABO antibodies (ABO-Ab) is a critical component of ABO-incompatible (ABOi) transplantation. ABO-Ab comprise both IgG and IgM, which…
2021 American Transplant Congress
Outcomes of Deceased Donor Transplants with Donor Specific Antibodies Before and After the New Kidney Allocation System
R. Crew, P. Khairallah, S. S. Patel
Columbia University, New York, NY
*Purpose: KAS forced centers to list unacceptable HLA antigens. Some centers excluded antigens at any level of anti-HLA Ab. Our center only excluded antibodies posing…
2021 American Transplant Congress
Contribution of T-bet Expressing CD27+ CD21- Activated Memory B Cells Poised for Plasma Cell Differentiation to Antibody-mediated Rejection of Kidney Transplants
K. Louis¹, E. Bailly¹, C. Macedo¹, B. Ramaswami¹, X. Gu¹, G. Chalasani¹, A. Zeevi¹, P. Randhawa¹, H. Singh², C. Lefaucheur³, D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Center for Systems immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ³Human Immunology and Immunopathology, INSERM U976, Paris, France
*Purpose: Alloimmunity triggered by donor-specific antibodies (DSAs) and ensuing development of antibody-mediated rejection (ABMR) are detrimental to organ transplants. Yet, the cellular states underlying B…
2021 American Transplant Congress
The Relevance of Naturally Occurring Non-HLA Antibody to Antibody Mediated Rejection in Patients without Anti-HLA Antibodies After Kidney Transplantation
H. Ishida¹, T. Shimizu², K. Unagami³, H. Shirakawa¹, K. Tanabe¹
¹Tokyo Womens, Tokyo 162-8666, Japan, ²Urology, Tokyo Womens, Tokyo 162-8666, Japan, ³Nephrology, Tokyo Womens, Tokyo 162-8666, Japan
*Purpose: Very few papers describe the association between non-HLA antibodies and the incidence of antibody mediated rejection (AMR) in kidney recipients. We investigated the incidence…
2021 American Transplant Congress
Novel Discovery of Super-antigen That Mobilize Regulatory Cd8 T Cells Inhibits Donor-specific Antibody and Protects Heart Allografts from Antibody-mediated Rejection
J. Y. Choi¹, H. Nakagawa², Z. Solhjou¹, K. Yatim¹, H. Zhang³, P. Patel³, M. Tawfeek Mohammed³, L. Riella⁴, H. Kim², H. Cantor², J. Azzi¹
¹Brigham and Women's Hospital/Harvard Medical School, Boston, MA, ²Dana Farber Cancer Institute/Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Antibody-mediated rejection (AMR) is a critical barrier to long-term allograft survival. We showed that Qa-1 (HLA-E in humans) restricted CD8+ T cells (CD8 Treg)…
2021 American Transplant Congress
Safety and Tolerability of Tacrolimus Extended-Release (astagraf Xl) in Hla Sensitized Kidney Transplant Recipients: A Single Center Experience
A. A. Vo, N. Ammerman, E. Huang, A. Peng, R. Najjar, S. Sethi, K. Lim, M. Gillespie, S. C. Jordan
Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Pill burden is a limitation in kidney transplant. Tacrolimus extended-release (Astagraf XL) is a once daily formulation approved for kidney transplantation. Increased compliance could…

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