2015 American Transplant Congress
Maintaining Immunosuppressive Treatment After Early Allograft Nephrectomy Does Not Reduce the Risk of Anti-HLA Allo-Sensitization
BackgroundAnti-HLA immunization is greatly increased after early kidney-allograft failure, even if the graft is removed within a few hours post-transplantation. The aim of our study…2015 American Transplant Congress
Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization
[Background] Preformed and newly formed alloantibody post transplantation (TX) can significantly deteriorate graft survival. Patterns of humoral rejection in sensitized patients varies significantly due to…2015 American Transplant Congress
Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function
Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…2015 American Transplant Congress
Etiology, Incidence and Outcomes of the Highly Sensitized Kidney Transplant Patient
University of Wisconsin, Madison, WI.
Background: Sensitization to HLA antigens is a major barrier to kidney transplantation. We sought to determine the etiology, incidence and outcomes of kidney transplants performed…2015 American Transplant Congress
Detection of Donor Specific HLA-Ab (DSA) Against Native HLA Molecules Expressed On Donor Cell Surface to Eliminate False Positive DSA in Luminex Single Antigen Beads (LMX-SAB)
Pathology, Stanford University, Palo Alto, CA.
Introduction:The LMX-SAB has been extensively used for DSA virtual crossmatch (VXM) to predict actual crossmatch (AXM). The extreme pH and harsh chemical reaction conditions used…2015 American Transplant Congress
Antibody-Induced Platelet Activation Increases Allograft Hyaluronan Fragmentation
Antibodies to MHC class I antigens have been shown to activate endothelial cells to release von Willebrand factor (vWf) and P-selectin from storage granules. These…2015 American Transplant Congress
Is Electron Microscopy Adding a Diagnostic Advantage in the Evaluation of Renal Allograft Biopsies for Antibody Mediated Rejection (AMR)?
Pathology and Medicine, University of Maryland School of Medicine, Baltimore, MD.
Some electron microscopy (EM) findings have been consistently associated with antibody mediated microvascular injury; however, no large studies have been performed examining the concrete advantage…2015 American Transplant Congress
Controlling Alloreactive B Cell Responses in Sensitized Recipients With CTLA-4Ig
Sensitized recipients are defined by the presence of pre-transplant donor-specific antibodies and have significantly poorer graft outcomes compared to unsensitized recipients despite efforts to desensitize.…2015 American Transplant Congress
Role of CMV, BKV, and Immunosupression Non-Adherence in Early and Late De Novo Donor Specific Anti-HLA Antibody Development and Outcomes
This analysis aims to identify appropriate de novo DSA (dnDSA) screening points and delineate the post-transplant (txp) scenarios preceding dnDSA development to aid in clinical…2015 American Transplant Congress
Alterations in Peripheral Blood B Cell Subpopulations in Kidney Transplant Recipients With DSA
Peripheral blood B cell subpopulations were assessed over time (1, 3, 6, 9, and 12 months) in living donor kidney transplant recipients undergoing thymoglobulin (n…
American Transplant Congress abstracts