ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Alloantibodies"

  • 2015 American Transplant Congress

    Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts

    M. Tonsho,1 G. Benichou,1 R. Smith,2 R. Colvin,2 J. Madsen.1,3

    1MGH Transplant Center, Massachusetts General Hospital, Boston, MA; 2Pathology, Massachusetts General Hospital, Boston, MA; 3Cardiac Surgery, Massachusetts General Hospital, Boston, MA.

    Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…
  • 2015 American Transplant Congress

    Burden of Early Antibody-Mediated Rejection (AMR): Complications, Resource Utilization and Cost-Differential in Treatment of AMR

    R. Banga,1 C. Schinstock,1 A. Boscoe,4 M. Hathcock,3 W. Kremers,3 M. Stegall.2

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; 2Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; 3Division of Biostatistics, Mayo Clinic, Rochester, MN; 4Health Outcomes Research, Alexion Pharmaceuticals, Cheshire, CT.

    Early antibody-mediated rejection (AMR) is common in positive crossmatch kidney transplants (+XMKTx). The current study determined the complications, resource utilization and cost associated with early,…
  • 2015 American Transplant Congress

    Deceased Donor and Class II Donor Specific Antibody Predict Interface Activity While Increased Age at Time of Biopsy Predicts Fibrosis in Long-Term Pediatric Liver Allografts With Normal Liver Tests: iWITH Clinical Trial

    S. Feng,1 J. Bucuvalas,2 A. Demetris,3 K. Spain,4 G. Mazariegos,3 B. Burrell,5 iWITH Investigators.6

    1UCSF, SF; 2U Cincinnati, Cincinnati; 3U Pittsburgh, Pittsburgh; 4Rho, Chapel Hill; 5ITN, Bethesda; 6NIAID/NIDDK/ITN, Bethesda.

    Background: Although multiple single centers have reported deterioration of pediatric liver grafts in the face of normal liver tests, neither risk nor mechanism is understood.Methods:…
  • 2015 American Transplant Congress

    Notch-1 Inhibition Promotes Immune Regulation in Solid Organ Transplantation

    C. Magee,1 M. Ohari,1 T. Shimizu,1 S. Ohori,1 N. Najafian,2 L. Riella.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Cleveland Clinic, Weston.

    Notch receptor signaling plays a key role in T cell activation and differentiation, though limited data exist on its importance in immune regulation. Herein, we…
  • 2015 American Transplant Congress

    A Single Center Study on Pregnacy and Allograf Function Outcomes Post Heart Transplant

    S. Adams, M. Wigger.

    Heart Transplant, Vanderbilt Medical Center, Nasvhille, TN.

    Pregnancy is a special time during a young woman's life, especially more so in those young women who are post heart transplant. The purpose of…
  • 2015 American Transplant Congress

    Pretransplant Antibodies Against Angiotensin II Type 1 Receptor in Renal Transplantation: Preliminary Data from the KNOW-KT Study

    K. Huh,1 J. Lee,1 Y. Park,2 Y. Kim,1 C. Ahn.3

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea; 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

    BackgroundThe antibodies (Abs) against angiotensin II type 1 receptor (AT1R) have been suggested as a risk factor for graft failure and acute rejection. However, incidence…
  • 2015 American Transplant Congress

    B-Cell Tolerance to Donor Alloantigens

    A. Patil, M. Climov, A. Matar, A. Musa, E. Harrington, D. Sachs, R. Duran-Struuck, C. Huang.

    Department of Surgery, Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.

    Pre-existing panel-reactive antibodies and development of donor-specific alloantibodies are known to play important roles in graft dysfunction and deterioration. Preventing and/or eliminating alloantibody responses would…
  • 2015 American Transplant Congress

    Elective Allograft Nephrectomy After Transplant Failure

    J. Augustine, K. Woodside, K. Noon, D. Hricik, E. Sanchez, J. Schulak.

    University Hospitals, Transplant Institute, Cleveland, OH.

    Background/Methods: Because of high rates of allograft intolerance and alloantibody sensitization after kidney transplant failure, we undertook a pilot study of elective allograft nephrectomy (ENx)…
  • 2015 American Transplant Congress

    Natural History of Anti- Human Leukocyte Antigen Antibodies After Hear Transplant

    J. Kobashigawa, M. Kittleson, F. Liou, S. Siddiqui, R. Shiozaki, L. Piponniau, D. Geft, M. Hamilton, L. Czer, N. Reinsmoen, J. Patel.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: The natural history of the production of circulating antibodies has not yet been clearly established. Recent technology has allowed for the improved detection of…
  • 2015 American Transplant Congress

    Complement Inhibition Via the Lectin Pathway Improves Experimental Cardiac Graft Survival

    J. Kindermann,1,2 M. Waechter,1,2 R. Bruno,1 M. Langenmayer,3 T. Dudler,4 W. Schwaeble,5 E. Kleinert,1 T. Mayr,1,2 H. Christian,2 R. Wanke,3 J.-M. Abicht,6 S. Guethoff.1

    1Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany; 2Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; 3Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany; 4Omeros Corporation, Seattle, WA; 5Department of Infection, Immunity, and Inflammation, Leicester University, Leicester, United Kingdom; 6Department of Anaesthesiology, Ludwig-Maximilians University, Munich, Germany.

    Purpose: While complement activation via both the classical as well as the lectin pathway is believed to contribute to allograft loss, their relative contribution is…
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