2016 American Transplant Congress
Impact of Donor Specific Antibodies on Cardiac Allograft Vasculopathy.
Purpose: Cardiac allograft vasculopathy (CAV) is a significant complication after cardiac transplantation (CTX). The presence of donor specific antibodies (DSA) has been associated with an…2016 American Transplant Congress
Factors Predicting Risk for Antibody-Mediated Rejection in Highly Sensitized Pediatric Renal Transplants.
Introduction: Antibody-mediated rejection (ABMR) is a concern in highly sensitized (HS) patients (pts) receiving renal transplant (tx). We have previously published that a donor specific…2016 American Transplant Congress
Ischemia Reperfusion Induced Murine Heart Transplant Rejection Is Complement Dependent.
Increased posttransplant ischemia reperfusion injury (IRI) prevents costimulatory blockade induced heart graft survival but mechanisms linking innate and adaptive immunity are poorly understood. Based on…2016 American Transplant Congress
Ibrutinib Suppresses Alloantibody Responses in A Mouse Model of Allosensitization: A Preliminary Report.
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Ibrutinib is a Bruton tyrosine Kinase (BTK) antagonist that inhibits B cell receptor (BCR) signaling, therefore blocking B cell activation. Ibrutinib is approved by…2016 American Transplant Congress
Frequency and Utility of Donor-Specific Antibody Testing in Simultaneous Liver Kidney Transplant.
Introduction: The risk of antibody mediated rejection (AMR) in simultaneous liver kidney (SLK) recipients is thought to be lower than in kidney alone patients due…2016 American Transplant Congress
De Novo DQA/DQB Donor Specific Antibodies (DSA) Is Associated with Allograft Dysfunction in Pediatric Liver Transplantation (LT).
Yale New Haven Transplantation Center, New Haven.
Antibody mediated rejection following LT is thought to be uncommon. Studies suggest HLA Ab that bind C1q may be deleterious to the TX allograft, &…2016 American Transplant Congress
Renal Fibroblast Activation and Survival by Anti-MHC Class I Antibody: The Role of mTOR Signaling Pathway.
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Background: Antibody-mediated injury (AMI) is an important contributor to late kidney allograft loss, and is accompanied by interstitial fibrosis (IF) and tubular atrophy (TA). However,…2016 American Transplant Congress
Clinical Significance of C3d Binding Donor Specific Anti-HLA Antibodies (DSA) Detected by Single Antigen Beads (SAB) After Kidney Transplantation.
A new Luminex-based SAB method detects DSA compliment fixing via C3d-binding. This study compares the clinical outcomes in kidney recipients that developed de novo DSA…2016 American Transplant Congress
Simultaneous Pancreas/Kidney Transplantation Increases the Risk of Late-Onset BKV-Associated Nephropathy.
Infections have increased in simultaneous pancreas/kidney transplant recipients (SPKTRs) with BKV-associated nephropathy (BKVN) being the most important infectious cause of allograft loss. Comparisons of BKVN…2016 American Transplant Congress
Recall Alloantibody Production Is Driven by CD138+ Cells Proliferating in the Spleens: An Indication for Long-Lived Plasma Cell Activities and Potential Therapeutic Target.
Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Donor-specific antibodies (DSA) generated in recall responses are produced by long-lived plasma cells (L-PC) residing in the bone marrows (BM). Mechanisms of L-PC activation,…
- « Previous Page
- 1
- …
- 31
- 32
- 33
- 34
- 35
- …
- 40
- Next Page »