Articles tagged "Alloantibodies"

2016 American Transplant Congress
Torque Teno Virus – Inverse Association with Late Silent Antibody Mediated Kidney Allograft Rejection.
G. Bond,¹ M. Schiemann,¹ F. Eskandary,¹ H. Herkner,² E. Puchhammer,³ R. Oberbauer,¹ G. Böhmig.¹
¹Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; ²Emergency Medicine, Medical University of Vienna, Vienna, Austria; ³Virology, Medical University of Vienna, Vienna, Austria.
Clinical Problem and hypothesis: Antibody mediated rejection (ABMR) is a cardinal cause of late graft failure after kidney transplantation (KTX). A promising predictive diagnostic tool…
2016 American Transplant Congress
Type of Sensitization Does Not Impact Kidney Graft Outcome in Weakly Sensitized Patients.
A. Morrison,¹ D. Sawinski,² M. Lim,² M. Levine,¹ M. Kamoun,³ P. Porrett.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Medicine, University of Pennsylvania, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: The impact of low level sensitization on kidney transplant (KTx) outcomes is unclear. While limited data suggest that KTx outcomes are comparable between weakly…
2016 American Transplant Congress
Pre-Transplant IgM to Post-Transplant IgG DSA Conversion May Be Affected by Immunosuppression.
A. Nguyen,¹ M. Everly,¹ L. Rebellato,² C. Haisch,² K. Briley,² P. Bolin,² S. Kendrick,² C. Morgan,² A. Maldonado,² P. Terasaki.¹
¹Terasaki Foundation Laboratory, Los Angeles, CA; ²East Carolina University, Greenville, NC.
Post-transplant (tx) IgG donor-specific antibodies (DSA), but not IgM DSA has been identified as one of the major causes of late graft loss. Considering the…
2016 American Transplant Congress
HLA Antibody in Transplant Recipients During Transition from Paediatrics.
S. Kaki,¹ A. Lunn,² J. Goodwin,³ T. Key,³ W. McKane.¹
¹Renal, Sheffield Kidney Institute, Sheffield, United Kingdom; ²Renal, Queens Medical Centre, Sheffield, United Kingdom; ³Histocompatibility and Immunogenetics, National Health Service blood and transplantation, Sheffield, United Kingdom.
Objective:Adolescent transplant recipients in transition from paediatric to adult units are known to be at high risk of graft failure. Detection of HLA antibody is…
2016 American Transplant Congress
Long-Term Follow-Up of Renal Transplant Recipients (RTR) Treated with IVIG for De Novo Donor Specific Antibodies (DSA).
R. Knight,¹ S. Patel,¹ J. Loucks-DeVos,² S. Kuten,¹ A. Gaber.¹
¹Houston Methodist Hospital, Houston, TX; ²Kansas University Medical Center, Kansas City, KS.
Intravenous immune globulin (IVIG) may be beneﬁcial for pre-emptive treatment of de novo DSA in RTR without biopsy-proven acute rejection (AR). Herein, we present long-term…
2016 American Transplant Congress
The Impact of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx) Is Independent of Time Post-Transplant.
R. Gaston,¹ J. Grande,² R. Leduc,³ The DeKAF Study Group.
¹Dept. of Medicine, University of Alabama at Birmingham, Birmingham, AL; ²Dept of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ³Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.
Detection of MVI in a KTxBx, often associated with antibody mediated rejection, is associated with a poor prognosis for kidney graft survival. However most information…
2016 American Transplant Congress
Pregnancy Excludes Women from Successful Living Donor Transplantation.
P. Porrett,¹ B. Bromberger,² S. Hashmi,¹ A. Morrison,¹ D. Sawinski.³
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Columbia University, New York, NY; ³Medicine, University of Pennsylvania, Philadelphia, PA.
INTRODUCTION Pregnancy-induced sensitization (PIS) is a barrier to the transplantation of women and contributes significantly to gender disparity in transplantation. We hypothesized that this barrier…
2016 American Transplant Congress
Post-Transplant T-Cell Alloreactive Perturbation Precedes the Advent of Humoral Immunity in Kidney Transplant Patients.
E. Crespo,¹ S. Luque,¹ J. Cruzado,² E. Melilli,² J. Grinyo,² M. Lucia,¹ O. Bestard.²
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.
Subclinical inflammation in kidney allografts is associated with worse outcome and the activation of humoral alloimmunity. Surveillance allograft biopsies are an accurate tool to diagnose…
2016 American Transplant Congress
MHC/HLA-Specific IgE in Allotransplantation.
A. Farkas,¹ U. Baranyi,¹ L. Unger,¹ B. Mahr,¹ K. Hock,¹ N. Pilat,¹ H. Regele,² M. Wahrmann,³ G. Böhmig,³ R. Valenta,⁴ T. Wekerle.¹
¹Dept. of Surgery, Medical University of Vienna, Vienna, Austria; ²Clin. Inst. of Pathology, Medical University of Vienna, Vienna, Austria; ³Dept. of Internal Medicine III, Medical University of Vienna, Vienna, Austria; ⁴Dept. of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Background: Donor-specific antibodies (DSA) are recognized as important factors in determining outcome in renal transplantation.Typically DSAs of the IgG isotype are measured, but little is…
2016 American Transplant Congress
Thrombalexin: Detection & Efficacy of a Membrane-Bound Anti-Thrombin Agent.
M. Manook,^1,2 J. Kwun,¹ J. Yoon,¹ S. Sacks,² A. Dorling,² N. Mamode,² R. Smith,² S. Knechtle.¹
¹Surgery, Duke University, Durham; ²King's College, London, United Kingdom.
Introduction: Early activation of coagulation may be an important factor in the initiation of innate immunity. Anti-coagulation in the transplant setting is difficult due to…