2017 American Transplant Congress
Accelerated De-Novo Donor-Specific Antibody-Mediated Rejection in a Non-Human Primate Model of Renal Transplantation.
Surgery - Division of Transplantation, University of Wisconsin-Madison, Madison, WI
The development of accelerated antibody-mediated rejection (ABMR) is associated with early allograft dysfunction and premature graft loss. In animals, pre-sensitization is usually required in order…2017 American Transplant Congress
The Incremental of Cost of Incompatible Living Donor Kidney Transplant: A National Cohort Analysis.
Incompatible living donor kidney transplant (ILDKT) has been established as an effective option for patients with willing but human leukocyte antigen incompatible live donors, reducing…2017 American Transplant Congress
TACI Polymorphisms Associated with De Novo Alloantibodies in Humans and Allograft Rejection in Mice.
A. Trans-membrane Activator and CAML Interactor (TACI) controls B cell differentiation and memory and exists as numerous allelic variants among healthy individuals and individuals with…2017 American Transplant Congress
Rapid Depletion of Circulating DSA and Treatment of Acute Antibody-Mediated Rejection with the Combination of CTLA-4Ig/Belatacept and Bortezomib in Mouse and Man.
1Sugery, University of Chicago, Chicago, IL; 2Surgery, The Ohio State University, Columbus, OH
Antibody mediated rejection (AMR) is a major cause of rejection, and there are limited therapeutic options for reversing alloantibody production when it is fully established.…2017 American Transplant Congress
Validation of a Novel Computational Approach for Predicting HLA Immunogenicity Based on Quantification of Structural and Surface Electrostatic Potential Differences Between Donor and Recipient HLA.
Background: Our preliminary work indicates that donor HLA immunogenicity in kidney and haematopoietic stem cell transplantation can be predicted by comparative assessment of donor and…2017 American Transplant Congress
Effects of Tofacitinib (JAK-3 Inhibitor) on De Novo HLA-A2 Antibody Production in a Mouse Model of Allo-Sensitization.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: Tofacitinib is a Janus Kinase Inhibitor currently approved by FDA for treatment of rheumatoid arthritis. In considering its effect in reducing B cell proliferation…2017 American Transplant Congress
De Novo Donor-Specific Antibodies After Allograft Nephrectomy.
Introduction: although the development of donor-specific antibodies (DSAs) is a known event after allograft nephrectomy (Nx), there are few studies describing the tempo, class and…2017 American Transplant Congress
Endocapillary NK Cells Are Increased in Indication Renal Transplant Biopsies with Antibody and T Cell Mediated Rejection.
Pathology, University of Michigan Medical School, Ann Arbor, MI
Detection of NK cell transcripts in renal transplant biopsies is associated with antibody mediated rejection (AMR). Similarly, quantification of endocapillary NK cells in paraffin tissue…2017 American Transplant Congress
Predictive Value of Pre-Transplant Cross-Match Techniques on Living Donor Kidney Transplant Outcomes.
Study aim: To investigate the impact of different cross-match techniques and their combination before living-donor kidney transplantation(LDKT) on main clinical outcomes.Methods: Retrospective study including 394…2017 American Transplant Congress
Differential Effect of Antibody Removal on ABO Blood Group Type Chain Specific Antibodies Over Time.
Introduction: The trisaccharide epitope defines A&B blood group antigens where antibody binds to subtype chains (I-VI), but only subtype II is expressed on cardiac vascular…
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