2017 American Transplant Congress
Clinical and Histopathologic Features of Antibody Mediated Rejection (ABMR) in Highly Sensitized (HS) vs Non-Sensitized (NS) Pediatric Renal Transplant Recipients.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: The presence of preformed donor-specific antibody (pDSA) in HS pts and development of de-novo DSA (dnDSA) in NS patients are risk factors for ABMR.…2017 American Transplant Congress
CTLA4Ig Suppresses Memory Responses to HLA-A2+ Skin Grafts in a Mouse Model of Allosensitization by Reducing CD138+ Plasma Cells.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: In previous studies we demonstrated that CTLA4Ig suppresses de novo T-cell activation through blocking CD28 co-stimulation and attenuates recall alloantibody responses following re-exposure to…2017 American Transplant Congress
Association of Non-HLA Antibodies with Histological Changes of Antibody Mediated Injury in Kidney Transplantation.
1Division of Nephrology, University of Washington, Seattle; 2Bloodworks NW, Seattle
Solid phase assays, particularly single-antigen beads, have substantially increased the sensitivity and accuracy of antibody detection in transplantation. However, donor specific antibodies(DSA) against human leukocyte…2017 American Transplant Congress
Effects of Anti-HLA Antibodies on Endothelial Expression and Serum Levels of Thrombomodulin in Kidney Recipients.
Medicine, Universite Laval, Quebec, QC, Canada
Background: Thrombomodulin (TBM) is an anticoagulant and anti-inflammatory protein expressed on endothelial cells (ECs). Mutations of TBM are seen in thrombotic microangiopathies due to aHUS.…2017 American Transplant Congress
Clinical Significance of Alloantibodies in Hand Transplantation: Impact on Rejection and Functional Outcome.
Purpose: Although alloantibodies, and donor-specific antibodies (DSA) in particular, are well-known to negatively impact graft survival in human solid organ transplantation, little is known about…2017 American Transplant Congress
Impact of a B-Cell Targeting Agent on Antibody Mediated Rejection and Graft' Survival in Liver Transplantation with Preformed DSAs.
Introduction The negative impact of preformed anti-HLA donor specific antibodies (DSAs) in liver transplantation is clearly established. However, the potential interest of a B-cell depleting…2017 American Transplant Congress
Non-Donor-Specific Anti-HLA Antibodies Have an Adverse Impact in Kidney Graft Outcomes.
1CHP, Porto, Portugal; 2IPST, Porto, Portugal
Few studies have studied the impact of non-donor-specific antibodies (NDSA) in kidney transplantation (KT), with most showing no impact of these antibodies. As antibody-mediated graft…2017 American Transplant Congress
APRIL/BLyS Inhibition Reduces Donor Specific Antibody in Sensitized Mice.
Background: Highly sensitized candidates on the kidney transplant waitlist remain a significant challenge as current desensitization protocols have variable success rates. Improved therapies are therefore…2017 American Transplant Congress
Delayed Tolerance Induction Protocol for Vascularized Composite Allografts in Non-Human Primates: The Immunomodulatory Effect of Donor Bone Marrow Transplantation Does Not Prevent the Development of Chronic Rejection in the Absence of Durable Mixed Chimerism.
Massachusetts General Hospital, Boston, MA
PURPOSE: Donor bone marrow transplantation (DBMT) has been investigated in experimental and clinical vascularized composite allotransplantation (VCA). With longer-term follow-up, reports of chronic VCA rejection…2017 American Transplant Congress
Emerging Safety and Tolerability of Obinutuzumab, a Type 2 Anti-CD20 Monoclonal Antibody for the Desensitization of Renal Transplant Candidates.
Background: Rituximab has limited efficacy for desensitizing allosensitized patients (pts) with end-stage renal disease (ESRD) and enabling kidney transplantation (KTx), however, tissue B-cell depletion is…
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