2018 American Transplant Congress
Humoral Immunity to CMV Remains Intact after Dual Targeting Desensitization in Allosensitized Nonhuman Primates
Department of Surgery, Duke University Medical Center, Durham, NC.
Desensitization to remove donor specific antibody (DSA) is a way to expand the pool of potential donors for sensitized patients. This study compared the effects…2018 American Transplant Congress
High Frequency of HLA-DQ De Novo Donor Specific Antibodies is Independent of the Number of Mismatches in Heart Transplant
Aim: Development of de novo donor specific antibodies (DSA) after heart transplant is associated with an increased risk of allograft failure. The aim of this…2018 American Transplant Congress
Circulating Follicular Helper T Cells (cTfh) in Renal Transplantation: Utility as Rejection Biomarker
Introduction: Antibody (Ab) mediated rejection is responsible for 30-50% of renal graft failures. Follicular helper T cells (Tfh) are required for the differentiation of B…2018 American Transplant Congress
NKG2C+CD57+ NK (G2C+57+) Cells Expanded by CMV Infection Are Highly Responsive to Allo-Antibody (Ab)-Mediated NK Cell Stimulation
Introduction: Active CMV infection is known to be associated with risk for ABMR in allograft recipients. Ab-dependent cellular cytotoxicity (ADCC) primarily mediated by NK cells…2018 American Transplant Congress
Association between Genetic Polymorphisms of Fc Gamma Receptor Genes (FcgR) and the Development of Donor Specific Antibodies (DSA) after Kidney Transplant
Background: Antibody mediated rejection (AMR) is one of the most important barriers to improve long-term kidney transplant outcomes. The presence of donor specific antibodies (DSA)…2018 American Transplant Congress
CTLA4-Ig and Bortezomib Successfully Reverses Established DSA Responses in Allograft-Sensitized Recipients
Background: Sensitized recipients have lower rates of transplantation and poorer outcomes. We and others have reported that the delayed administration of CTLA4-Ig can disrupt fully-established…2018 American Transplant Congress
The Likelihood of Re-Transplantation in Patients Undergoing Allograft Nephrectomy
Introduction: transplant nephrectomy (NX) is a known cause of allosensitisation after graft failure. As yet, there is no consensus for the management of the patient…2018 American Transplant Congress
Pre-Transplant versus De Novo Donor Specific Antibodies: Differences in Clinical Outcomes and Antibody Mediated Rejection
Montefiore-Einstein Transplant Center, Montefiore-Einstein Transplant Center, Bronx.
Background: Antibody mediated rejection (ABMR) can occur through pre-transplant(tx) vs. de novo donor specific antibodies (DSA). Clinical outcomes, allograft injury and dynamics of DSAs have…2018 American Transplant Congress
Urinary Tract Infections May Be Associated with De Novo Donor-Specific Anti-Human Leucocyte Antigen Antibodies: Single-Center Study
Introduction: We have recently shown that immunosuppression reduction with BK virus is associated with the development of de novo donor anti-human leukocyte antigen-specific antibodies (dnDSA).…2018 American Transplant Congress
APRIL/BLyS Blockade Improves Depletion of Antibody Secreting B Cells Compared to BLyS Blockade Alone in Sensitized Murine Kidney Transplant Model
1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI.
Introduction: Antibody mediated rejection (AMR) remains a significant problem in highly sensitized individuals undergoing kidney transplantation. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte…
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