Articles tagged "Alloantibodies"

2019 American Transplant Congress
Long-Term Kidney Graft Evolution in Simultaneous Liver-Kidney Transplants with Immunological Risk
G. J. Piñeiro¹, E. Montagud¹, J. Ugalde¹, R. Gelpi¹, V. Torregrosa¹, J. Rovira², J. Colmenero³, F. Diekmann¹, N. Esforzado¹
¹Nephrology and Kidney Transplantation, Hospital Clínic of Barcelona, Barcelona, Spain, ²Nephrology and Kidney Transplantation, Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain, ³Liver Transplant Unit, Hospital Clínic of Barcelona, Barcelona, Spain
*Purpose: There is disagreement about the real impact of anti-HLA sensitization on patient and kidney graft survival in simultaneous liver-kidney transplant (SLKT).*Methods: We reviewed the…
2019 American Transplant Congress
Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation
J. Y. Choi¹, S. K. Eskandari¹, J. Assaker¹, I. Sulkaj¹, S. Cai¹, H. Allos¹, M. Uehara¹, M. Mohammad¹, B. S. Al Dulaijan¹, A. Bano¹, E. Al Huassain¹, H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Dana-Farbar Caner Institute, Boston, MA
*Purpose: HLA-E is an MHC class-1b molecule that is under-studied in the transplant setting. Recent clinical studies have revealed a robust association between allograft outcome…
2019 American Transplant Congress
ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy
D. Jane-wit¹, C. Fang¹, L. Liu¹, L. Qin¹, G. Guangxin Li¹, P. Nigrovic², G. Tellides³, J. Pober⁴
¹Dept of Cardiology, Yale University School of Medicine, New Haven, CT, ²Dept of Rheumatology, Immunology, and Allergy, Harvard University, Boston, MA, ³Dept of Surgery, Yale University School of Medicine, New Haven, CT, ⁴Dept of Immunobiology, Yale University School of Medicine, New Haven, CT
*Purpose: Complement promotes vascular inflammation in transplant organ rejection, a process leading to cardiac allograft vasculopathy. In this study, we identify a new Rab5 effector…
2019 American Transplant Congress
APRIL^-/-/BLyS^-/-Deplete Antibody Secreting Cells and Alloantibody Production in Sensitized Antibody Mediated Rejection Model
N. Bath, B. Verhoven, N. Wilson, R. Redfield III
University of Wisconsin, Madison, WI
*Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A proliferation inducing ligand) and BLyS (B Lymphocyte Stimulator) are two…
2019 American Transplant Congress
Vaccination And Allosensitization In Solid Organ Transplant Candidates
L. Lourenco¹, K. B. Bain², L. Bowman³, D. C. Brennan⁴, G. A. Ewald⁵, R. R. Hachem⁶
¹Pharmacy, University of Chicago Medicine, Chicago, IL, ²Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, ³Pharmacy, Tampa General Hospital, Tampa, FL, ⁴Internal Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, ⁵Heart Failure and Heart Transplantation, Washington University School of Medicine, St. Louis, MO, ⁶Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO
*Purpose: Clinical practice guidelines recommend vaccinating patients awaiting solid organ transplantation (SOT) against vaccine-preventable infections, but there is little evidence to suggest that vaccination reduces…
2019 American Transplant Congress
Variable Glycosylations of Anti-HLA Antibodies Detected with Single Antigen Beads in Kidney Transplant Recipients
Y. Chang¹, N. Lemp², J. Cicciarelli¹, T. Shah³, D. Min⁴
¹Mendez National Institute of Transplantation Foundation, Los Angeles, CA, ²Transplantation Research, Mendez National Institute of Transplantation Foundation, Los Angeles, CA, ³St. Vincent Medical Center, Los Angeles, CA, ⁴Western Univ of Health Sciences, Pomona, CA
*Purpose: Differential glycosylation of Immunoglobulin G (IgG) is known to affect its effector functions by modulating interactions with its binding partners, such as C1q or…
2019 American Transplant Congress
Ligation Of Hla Class Il Molecules Disrupts Endothelial Barrier Through Src-dependent Ve-cadherin Destabilization
F. Li¹, R. A. Sosa¹, N. M. Valenzuela¹, E. Rozengurt², E. F. Reed¹
¹Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²Digestive Diseases Research Center, University of California, Los Angeles, Los Angeles, CA
*Purpose: Microvascular inflammation, vascular permeability, and accumulation of intravascular mononuclear cells are characteristics of acute and chronic antibody-mediated rejection. Vascular endothelial cadherin (VE-Cadherin) is a…
2019 American Transplant Congress
Interleukin-27 is Required for Donor Specific Antibody Production in Response to Heart Allograft Transplantation
M. Nicosia, S. Miyairi, R. Fan, A. Beavers, V. Gorbacheva, A. Valujskikh
Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Interleukin-27 (IL-27), a member of IL-12 cytokine family, is involved in both pro- and anti-inflammatory immune responses. Previously we reported that B cell derived…
2019 American Transplant Congress
Development of De Novo DSA after Kidney Transplant Correlates with Low Quantity of Peripheral Blood “Antibody-Suppressor” CD8⁺T Cells
J. Zimmerer¹, M. Basinger¹, B. Ringwald¹, R. Pelletier¹, A. Rajab¹, A. El-Hinnawi¹, M. Abdel-Rousoul², H. Parekh³, K. Washburn¹, G. Bumgardner¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, ³Clinical Histocompatibility Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: It is well known that CD4+ T cells provide “help” for antibody production in vivo. Our group discovered a novel subset of murine antibody-suppressor…
2019 American Transplant Congress
α -1,3-galactosyltransferase Knockout Porcine Tissue And Organ May Reduce The Risks Of Antibody Mediated Rejection Via Less Rhesus Igm Cross-reactivity.
J. Yoon, B. Ezekian, M. Manook, J. Kwun, S. Knechtle
Duke Transplant Center, Durham, NC
*Purpose: Previously, we observed that sera from rhesus macaques contained preformed antibodies against wild type (WT) swine splenocytes. In the context of xenotransplantation, preformed xenoantibodies…