Articles tagged "Alloantibodies"

2020 American Transplant Congress
Role of B-Cell Subsets in Allograft Rejection in Intestinal Transplantation
H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. Fishbein, A. Kroemer
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: While B-cells contribute to allograft rejection by presenting antigens to T-cells and by producing donor-specific antibodies (DSAs) and various cytokines, their pathophysiology in transplant…
2020 American Transplant Congress
Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Rejection – Molecular Rebound Phenomena Under IL-6 Blockade?
A. Borski¹, S. Haindl², M. Duerr³, K. Budde³, S. Schranz¹, F. A. Eskandary², K. Doberer², P. F. Halloran⁴, E. Chong⁵, B. Jilma¹, G. A. Böhmig², M. Wahrmann²
¹Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Medical University of Vienna, Vienna, Austria, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Vitaeris Inc., Vancouver, BC, Canada
*Purpose: Late antibody-mediated rejection (ABMR) is well established as a major cause of kidney allograft failure. Targeting interleukin-6 (IL-6), a pro-inflammatory cytokine involved in B…
2020 American Transplant Congress
Targeting the CD40/CD40L Axis in Sensitized Nonhuman Primate Allotransplantation
Z. W. Fitch, R. Schmitz, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, S. J. Knechtle
Duke University, Durham, NC
*Purpose: Blockade of the CD28/B7 costimulation pathway has shown great promise as part of desensitization and maintenance immunosuppression regimens in our sensitized nonhuman primate model.…
2019 American Transplant Congress
Circulating Donor Specific Antibody and Biopsy C4d Positivity in Pancreas Rejection Increase the Probability of Earlier Return to Insulin after Rejection
S. M. Riad¹, S. Jackson², E. B. Finger³, R. Kandaswamy³
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Outcome data following rejection in pancreas recipients are sparse. We sought to study the influence of C4d positivity and the presence of circulating DSA…
2019 American Transplant Congress
A Prognostic Biomarker to Estimate the Likelihood of Developing De Novo Donor Specific Antibody in Kidney Transplant Recipients
S. Kawakita¹, L. M. Rebellato², K. P. Briley², A. Q. Maldonado³, C. E. Haisch², P. Bolin², S. A. Kendrick⁴, H. Jones⁴, K. McLawhorn⁴, D. Leeser², V. Jucaud¹, V. Burnett¹, M. J. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Vidant Medical Center, Greenville, NC, ⁴Eastern Nephrology Associates, Greenville, NC
*Purpose: Evaluation of human leukocyte antigen (HLA) mismatch at antibody epitope level rather than antigen level may explain better the impact of HLA mismatch on…
2019 American Transplant Congress
Development of De Novo Antibody in Renal Transplant Recipients with BK Viremia Managed with Immunosuppression Reduction
M. Raijmakers¹, A. Shetty², R. Hod Dvorai², A. Tambur², M. G. Ison²
¹University of Santiago, Santiago, Chile, ²Northwestern University Comprehensive Transplant Center, Chicago, IL
*Purpose: To determine the development of de novodonor specific antibodies (DSA) in renal transplant recipients with immunosuppression modulation and BK viremia and the associated risk…
2019 American Transplant Congress
Belatacept Monotherapy in Kidney Transplant Recipients with Failed Allografts Reduces Humoral Sensitization in a Single Center Randomized Controlled Trial
I. R. Badell, R. Elbein, R. A. Bray, H. M. Gebel, A. B. Adams, C. P. Larsen
Emory University School of Medicine, Atlanta, GA
*Purpose: Kidney transplant recipients with failed allografts suffer from high rates of humoral sensitization. Immunosuppression (IS) strategies are highly variable in these patients with many…
2019 American Transplant Congress
Next Gen ABO Antibody Assessment: Development of a Bead-Based ABO Antibody Detection Assay
A. Halpin¹, J. Pearcey², B. Motyka², S. Maier², J. Zhou³, T. L. Lowary⁴, C. W. Cairo⁴, L. J. West¹
¹Dept of Pediatrics, Dept of Laboratory Medicine, GlycoNet, ATI, CDTRP, University of Alberta, Edmonton, AB, Canada, ²Dept of Pediatrics, ATI, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada, ³Dept of Laboratory Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Dept of Chemistry, GlycoNet, CDTRP, University of Alberta, Edmonton, AB, Canada
*Purpose: Accurate characterization of ABO antibodies (ABO-Ab) is critical to assess their impact in ABO incompatible (ABOi) transplantation. The current ABO-Ab detection method using erythrocyte…
2019 American Transplant Congress
ABMR In Low-single Dose Thymoglobulin Induction Protocol In Renal Transplant Recepients From A Tertiary Care Centre In A Developing Country
R. Parthasarathy¹, M. Mohammed¹, P. Koshy², I. Pradeep², M. Mathew¹, G. Abraham¹
¹Nephrology, Madras Medical Mission, Chennai, India, ²Pathology, Madras Medical Mission, Chennai, India
*Purpose: Fool proof induction therapy in low sensitized patients is still elusive. There is a thin line between over immunosuppression and infection . Conventional rabbit…
2019 American Transplant Congress
Clazakizumab as an Agent to Reduce Donor Specific HLA Antibodies and Improve Outcomes in Patients with Chronic & Active Antibody-Mediated Rejection Post-Kidney Transplantation
S. C. Jordan¹, N. Ammerman¹, M. Toyoda², E. Huang¹, C. C. Nast³, A. Peng¹, S. Sethi¹, R. Najjar¹, I. Kim¹, K. Lim¹, J. Choi¹, A. Vo¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Ctr, Los Angeles, CA, ²Transplant Immunology Lab, Cedars-Sinai Medical Ctr, Los Angeles, CA, ³Department of Pathology, Cedars-Sinai Medical Ctr, Los Angeles, CA
*Purpose: Highly sensitized (HS) patients are at an increased risk for chronic antibody mediated rejection (cABMR) and graft loss due to persistent, deleterious DSA production.…