Articles tagged "Alloantibodies"

2020 American Transplant Congress
De Novo DSA in the Setting of Stable Renal Allograft Function Does Not Impair Long-Term Graft Survival
R. Knight¹, D. T. Nguyen², E. A. Graviss², O. Gaber¹
¹Surgery, Houston Methodist Hospital, Houston, TX, ²Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: To determine the long-term outcome of renal allograft recipients with de novo DSA (dnDSA) in the setting of stable allograft function.*Methods: A single-center review…
2020 American Transplant Congress
Activated Circulating Memory TFollicular Helper Cells with Self-Renewal Potential Underlie the Kidney Allograft Antibody-Mediated Rejection Response
K. Louis¹, C. Macedo¹, E. Bailly¹, B. Ramaswami¹, M. Marrari¹, T. Shi¹, D. Landsittel¹, U. Chandran¹, P. Fadakar¹, M. Yamada¹, G. Chalasani¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: Antibody-mediated rejection (ABMR) is the leading cause of allograft failure after organ transplantation. Yet, the cellular events that lead to the induction of a…
2020 American Transplant Congress
Estimating Alloantibody Levels in Highly-Sensitized Renal Allograft Candidates Using Serial Dilutions
C. Maguire¹, A. R. Tambur¹, C. Schinstock², M. D. Stegall²
¹Northwestern University, Chicago, IL, ²Mayo Clinic, Rochester, MN
*Purpose: Despite the new Kidney Allocation System and Kidney Paired Donation, renal allograft candidates with a >99.9% cPRA still have extremely low rates of transplantation…
2019 American Transplant Congress
NK Cells Are Associated with Alloimmune Failure in Transplanted Children
E. T. Chambers¹, O. Martinez², M. Robien³, C. Chan¹, R. Ettenger⁴, P. Grimm⁵, H. Lee¹, E. Reed⁴, L. Stempora⁶, M. Sarwal⁷, B. Warshaw⁸, C. Zhao¹, A. D. Kirk⁶
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Stanford, Palo Alto, CA, ³NIH, Bethesda, MD, ⁴Pediatrics, UCLA, Los Angeles, CA, ⁵Pediatrics, Stanford, Stanford, CA, ⁶Surgery, Duke University, Durham, NC, ⁷Pediatrics, UCSF, San Francisco, CA, ⁸Pediatrics, Emory University, Atlanta, GA
*Purpose: Alloimmune failure, defined as the development of donor specific antibody (DSA) and/ or allograft rejection, remains a significant complication in pediatric kidney transplantation. NK…
2019 American Transplant Congress
Alloreactive B Cells in Transplant Tolerant Recipients Cannot Differentiate into Antibody-Secreting Cells but Can Suppress Donor-Specific IgG Production By Naïve B Cells
S. H. Khiew¹, J. Chen¹, D. Jain¹, Q. Wang¹, D. Yin¹, M. Alegre², A. S. Chong¹
¹Department of Surgery, Section of Transplant, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Donor specific transplantation tolerance has long been the goal of clinical transplantation. Clinical observations suggest that donor-specific antibodies (DSA) are a major cause of…
2019 American Transplant Congress
Long-Term Kidney Graft Evolution in Simultaneous Liver-Kidney Transplants with Immunological Risk
G. J. Piñeiro¹, E. Montagud¹, J. Ugalde¹, R. Gelpi¹, V. Torregrosa¹, J. Rovira², J. Colmenero³, F. Diekmann¹, N. Esforzado¹
¹Nephrology and Kidney Transplantation, Hospital Clínic of Barcelona, Barcelona, Spain, ²Nephrology and Kidney Transplantation, Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain, ³Liver Transplant Unit, Hospital Clínic of Barcelona, Barcelona, Spain
*Purpose: There is disagreement about the real impact of anti-HLA sensitization on patient and kidney graft survival in simultaneous liver-kidney transplant (SLKT).*Methods: We reviewed the…
2019 American Transplant Congress
Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation
J. Y. Choi¹, S. K. Eskandari¹, J. Assaker¹, I. Sulkaj¹, S. Cai¹, H. Allos¹, M. Uehara¹, M. Mohammad¹, B. S. Al Dulaijan¹, A. Bano¹, E. Al Huassain¹, H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Dana-Farbar Caner Institute, Boston, MA
*Purpose: HLA-E is an MHC class-1b molecule that is under-studied in the transplant setting. Recent clinical studies have revealed a robust association between allograft outcome…
2019 American Transplant Congress
ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy
D. Jane-wit¹, C. Fang¹, L. Liu¹, L. Qin¹, G. Guangxin Li¹, P. Nigrovic², G. Tellides³, J. Pober⁴
¹Dept of Cardiology, Yale University School of Medicine, New Haven, CT, ²Dept of Rheumatology, Immunology, and Allergy, Harvard University, Boston, MA, ³Dept of Surgery, Yale University School of Medicine, New Haven, CT, ⁴Dept of Immunobiology, Yale University School of Medicine, New Haven, CT
*Purpose: Complement promotes vascular inflammation in transplant organ rejection, a process leading to cardiac allograft vasculopathy. In this study, we identify a new Rab5 effector…
2019 American Transplant Congress
APRIL^-/-/BLyS^-/-Deplete Antibody Secreting Cells and Alloantibody Production in Sensitized Antibody Mediated Rejection Model
N. Bath, B. Verhoven, N. Wilson, R. Redfield III
University of Wisconsin, Madison, WI
*Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft failure. APRIL (A proliferation inducing ligand) and BLyS (B Lymphocyte Stimulator) are two…
2019 American Transplant Congress
Vaccination And Allosensitization In Solid Organ Transplant Candidates
L. Lourenco¹, K. B. Bain², L. Bowman³, D. C. Brennan⁴, G. A. Ewald⁵, R. R. Hachem⁶
¹Pharmacy, University of Chicago Medicine, Chicago, IL, ²Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, ³Pharmacy, Tampa General Hospital, Tampa, FL, ⁴Internal Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, ⁵Heart Failure and Heart Transplantation, Washington University School of Medicine, St. Louis, MO, ⁶Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO
*Purpose: Clinical practice guidelines recommend vaccinating patients awaiting solid organ transplantation (SOT) against vaccine-preventable infections, but there is little evidence to suggest that vaccination reduces…