2020 American Transplant Congress
Targeting the CD40/CD40L Axis in Sensitized Nonhuman Primate Allotransplantation
*Purpose: Blockade of the CD28/B7 costimulation pathway has shown great promise as part of desensitization and maintenance immunosuppression regimens in our sensitized nonhuman primate model.…2020 American Transplant Congress
Notch Signaling Inhibition via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…2020 American Transplant Congress
Clinical Significance of Late Antibody-Mediated Rejection without Donor Specific Anti-hLA Antibodies
*Purpose: Late onset antibody-mediated rejection (AMR) is a leading cause of kidney allograft failure. Its diagnosis has been based on a combination of morphologic, immunohistologic…2020 American Transplant Congress
Isolation of Preformed Antibodies from Whole Blood by Integrating Acoustics and Microfluidics in Sensitized Animal Model
*Purpose: Apheresis therapy refers to the separation, removal and/or exchange of unwanted blood components (red cells, white cells, platelets and/or plasma) by centrifugation and return…2020 American Transplant Congress
Costimulation Blockade-Based Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Sensitized transplant recipients represent a challenging population in part due to the presence of donor-specific antibodies (DSA), which increase the risk of antibody-mediated rejection.…2020 American Transplant Congress
Late De Novo Donor Specific Antibodies in Steroid Free Immunosuppression and Delayed Graft Function
Temple University School of Medicine, Philadelphia, PA
*Purpose: Donor Specific Antibodies (DSA) have been implicated in acute and chronic antibody-mediated rejection. Once developed, they tend to be persistent and lead to transplant…2020 American Transplant Congress
Recipient LAG3 Deficiency Results in Antibody-Mediated Rejection of Mouse Renal Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphocyte activation gene-3 (LAG3) is a coinhibitory receptor on the surface of T and B lymphocytes, NK cells and plasmacytoid dendritic cells. Its functions…2020 American Transplant Congress
Preformed Donor Specific Antibody and Mfi-Dependent Effects in Simultaneous Liver-Kidney Transplantation
Department of Transplantation, University of Wisconsin, Madison, WI
*Purpose: Preformed donor specific antibody to HLA Class II (pDSA) is suggested to be an independent risk factor for mortality in simultaneous liver and kidney…2020 American Transplant Congress
Impact of the Baseline Anti-A/B IgG Titer on the Clinical Outcome in ABO-Incompatible Liver Transplantation
*Purpose: The use of ABO incompatible (ABOi) living donors is an attractive solution for expanding the liver donor pool. We investigated the impact of the…2020 American Transplant Congress
B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4+ T Cell Responses in Highly Sensitized Transplant Model
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…
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