Articles tagged "Alloantibodies"

2020 American Transplant Congress
Novel Role of Qa-1, a Murine Homolog of HLA-E, in Controlling Follicular Helper T Cells During Humoral Alloimmunity
J. Y. Choi¹, S. K. Eskandari¹, S. Cai¹, J. Assaker¹, I. Sulkaj¹, H. Allos¹, J. Alhaddad¹, P. Chu¹, H. Kim², H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Immunology, Dana Farber Cancer Institute, Boston, MA
*Purpose: Antibody-mediated rejection (AMR) is a major challenge in prolonging allograft survival. Limited insight into the humoral alloimmunity hinders the development of therapeutic strategies. We…
2020 American Transplant Congress
De Novo DSA in the Setting of Stable Renal Allograft Function Does Not Impair Long-Term Graft Survival
R. Knight¹, D. T. Nguyen², E. A. Graviss², O. Gaber¹
¹Surgery, Houston Methodist Hospital, Houston, TX, ²Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: To determine the long-term outcome of renal allograft recipients with de novo DSA (dnDSA) in the setting of stable allograft function.*Methods: A single-center review…
2020 American Transplant Congress
Activated Circulating Memory TFollicular Helper Cells with Self-Renewal Potential Underlie the Kidney Allograft Antibody-Mediated Rejection Response
K. Louis¹, C. Macedo¹, E. Bailly¹, B. Ramaswami¹, M. Marrari¹, T. Shi¹, D. Landsittel¹, U. Chandran¹, P. Fadakar¹, M. Yamada¹, G. Chalasani¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm UMR 976, Paris, France
*Purpose: Antibody-mediated rejection (ABMR) is the leading cause of allograft failure after organ transplantation. Yet, the cellular events that lead to the induction of a…
2020 American Transplant Congress
Estimating Alloantibody Levels in Highly-Sensitized Renal Allograft Candidates Using Serial Dilutions
C. Maguire¹, A. R. Tambur¹, C. Schinstock², M. D. Stegall²
¹Northwestern University, Chicago, IL, ²Mayo Clinic, Rochester, MN
*Purpose: Despite the new Kidney Allocation System and Kidney Paired Donation, renal allograft candidates with a >99.9% cPRA still have extremely low rates of transplantation…
2020 American Transplant Congress
Are HLA-DQ De Novo Donor-Specific Antibodies a Risk Factor for Acute Humoral Rejection?
R. Hod Dvorai¹, C. A. Hubbell¹, M. R. Laftavi², R. Shahbazov², B. Gallay³, O. G. Pankewycz³
¹Pathology, SUNY Upstate Medical University, Syracuse, NY, ²Surgery, SUNY Upstate Medical University, Syracuse, NY, ³Medicine, SUNY Upstate Medical University, Syracuse, NY
*Purpose: To identify HLA-DQ de novo donor-specific antibodies (dnDSA) characteristics associated with acute humoral rejection (ABMR) and response to treatment.*Methods: We performed a retrospective analysis…
2020 American Transplant Congress
The Effect of Desensitization Therapy on Sex Disparity in Living Kidney Transplantation
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: Sex- and gender-based disparities which have shown women to have lower access to kidney transplantation have been reported. In living kidney transplantation (LKT), pregnancy-related…
2020 American Transplant Congress
Incidence of Antibody Mediated Rejection in Living Kidney Transplant Recipients with Sensitizing History
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Regulation, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: A donor-reactive alloimmune memory response can arise from prior exposure to foreign human leukocyte antigen by sensitization history in transplant recipients. Assessing risk levels…
2020 American Transplant Congress
Quantitative Analysis of Humoral Immunity by Flow-Cytometric Crossmatch Using Molecules of Equivalent Soluble Fluorochromosome (FCXM-MESF)
H. Ishida, M. Furusawa, T. Shimizu, M. Okumi, Y. Kakuta, K. Omoto, K. Tanabe
Tokyo Womens, Tokyo, Japan
*Purpose: In this study, we examined the quantitative significance of humoral immunity by flow-cytometric crossmatch using molecules of equivalent soluble fluorochromosome (FCXM-MESF) in recipients of…
2020 American Transplant Congress
Kidney Transplant Recipients with De Novo Donor Specific Antibody is Associated with Increased Risk of Developing BK Viremia
S. Kareem¹, L. Suresh², A. Gundroo¹, J. Von Viger¹, S. Chang¹
¹Internal Medicine, University of Buffalo, Buffalo, NY, ²Pathology, University of Buffalo, Buffalo, NY
*Purpose: Background: De novo donor specific anti-HLA antibodies (dnDSA) has profound effect on the renal graft long-term function and survival. Studies has shown identifications of…
2020 American Transplant Congress
Association between Education and Waitlist Mortality, Access to Transplant, and Post-Transplant Survival among Patients with Alcohol-Associated Liver Disease
A. T. Strauss, J. Motter, D. Segev, A. Massie, T. Purnell, J. Hamilton, A. Gurakar, A. Cameron, J. Garonzik-Wang
Johns Hopkins University, Baltimore, MD
*Purpose: Alcohol-associated liver disease (ALD) is the leading indication for liver transplant (LT) and these patients have been shown to have worse outcomes compared to…

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