Articles tagged "Age factors"

2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
P. Gauthier, A. Aleshin, S. Shchegrova, T. Mckenna, E. Kalashnikova, S. Sharma, H. Sethi, R. Salari, R. Swenerton, Z. Demko, B. Zimmermann, P. Billings
Natera, Inc., San Carlos, CA
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…
2020 American Transplant Congress
Liver Transplant Outcomes Across the Age Distribution and Interactions with County Health
S. K. Niazi¹, E. Vargas², A. Spaulding³, J. Crook², T. Schneekloth⁴, A. Keaveny⁵, A. Vasquez⁶, M. Gentry⁴, T. Rummans⁶, C. Taner⁵
¹Psychiatry & Psychology; Transplantation, Mayo Clinic, Jacksonville, FL, ²Health Sciences Research, Mayo Clinic, Jacksonville, FL, ³Heath Sciences Research, Mayo Clinic, Jacksonville, FL, ⁴Psychiatry & Psychology, Mayo Clinic, Rochester, MN, ⁵Transplantation, Mayo Clinic, Jacksonville, FL, ⁶Psychiatry & Psychology, Mayo Clinic, Jacksonville, FL
*Purpose: We examined risk of graft failure and patient mortality after liver transplant (LT) across the age continuum and county Health Outcomes & Health Factors…
2020 American Transplant Congress
From Marginal to Meaningful: Donor Liver Biopsy Increases Donation Rates amongst Elderly Donors
J. A. Steggerda¹, M. B. Bloom¹, K. Mahendraraj¹, G. Voidonikolas¹, T. Todo¹, M. Noureddin², N. N. Nissen¹, A. S. Klein¹, I. K. Kim¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA, ²Hepatology, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA
*Purpose: Recently, there has been public scrutiny on the non-utilization of elderly donors in liver transplantation. Here, we evaluate the influence of donor liver biopsy…
2020 American Transplant Congress
Older Organs Transfer Senescence to Transplant Recipients
J. Iske¹, R. Maenosono¹, M. Seyda¹, T. Heinbockel¹, M. Koichiro¹, Y. Nian¹, T. Tchkonia², J. L. Kirkland², R. Abdi¹, A. Elkhal¹, S. G. Tullius¹
¹Brigham and Women's Hospital, Boston, MA, ²Mayo Clinic, Rochester, MN
*Purpose: Older organs represent an underutilized potential. Organ age, at the same time, augments alloimmune responses resulting into increased acute rejection rates. Senescent cells accumulate…
2019 American Transplant Congress
Infectious Complications in Kidney Transplant Recipients Age 65 and Older
L. E. Liriano-Ward¹, M. Barbachan e Silva², Y. Azzi¹, M. Ajaimy¹, A. Cambell¹, J. Graham¹, J. Rocca¹, C. Pynadath¹, G. Nair¹, O. Andacoglu¹, S. Greenstein¹, P. Ó Broin², E. Akalin¹
¹Transplant, Einstein/Montefiore Medical Center, Bronx, NY, ²School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway, Galway, Ireland
*Purpose: Kidney transplant recipients age 65 years and older are at higher risk for development of infections. We aimed to investigate the incidence of both…
2019 American Transplant Congress
The Power of Young Donor Liver; Elixir of Life for Sick Liver Transplant Recipient
J. Kusakabe¹, J. McVey², D. J. Firl², M. Fujiki², F. N. Aucejo², C. Quintini², K. Hashimoto², K. Sasaki²
¹Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Cleveland Clinic Foundation, Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Young donor organs are known to have significant prognostic benefits in liver transplantation (LT). However, details of short- and long-term prognostic benefits of young…
2019 American Transplant Congress
Poor Outcomes in Kidney Transplant Candidates & Recipients with History of Falls
N. Chu¹, H. Ying¹, Z. Shi¹, C. Haugen¹, S. Norman², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins, Baltimore, MD, ²Michigan Medical Center, Ann Arbor, MI
*Purpose: In patients with ESRD, serious fall injuries (e.g. fractures) are associated with decreased chance of listing or transplantation. It is likely that KT candidates…
2019 American Transplant Congress
Combined Ischemic and Rapamycin Preconditioning Alleviated Liver Ischemia and Reperfusion Injury by Restoring Autophagy in Old Mice
Z. Rao, X. Pan, W. Zhong, Z. Ding, H. Zhou, C. Liu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the…
2019 American Transplant Congress
Outcomes of Liver Transplantation for Hepatocellular Carcinoma in Septuagenarians
M. Najjar¹, K. Bruestle¹, P. Jiang¹, E. Lieberman¹, R. Hwang¹, A. Mathur¹, E. C. Verna¹, A. Griesemer¹, B. Samstein², T. Kato¹, Y. M. Saenger¹, K. J. Halazun², J. C. Emond¹
¹Columbia University Medical Center, New York, NY, ²Weill Cornell Medicine, New York, NY
*Purpose: The impact of advanced age on liver transplantation (LT) for hepatocellular carcinoma (HCC) has not been well studied. We sought to compare post-OLT survival…
2019 American Transplant Congress
Senescent Cell Clearance with Senolytic Drugs Improves Cardiac Allograft Survival by Targeting mt-DNA Mediated Immune Responses
J. Iske¹, M. Koichiro¹, M. Seyda¹, T. Heinbokel¹, Y. Nian¹, R. Maenosono¹, H. Azuma¹, C. Falk², T. Tchokonia³, J. Kirkland³, A. Elkhal¹, S. Tullius¹
¹Transplant Surgery, Brigham and Women's Hospital, Boston, MA, ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ³Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN
*Purpose: Older organs represent an underutilized potential. We dissected alloimmune responses when transplanting older organs and tested if the depletion of senescent cells in older…

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