Articles tagged "Age factors"

2016 American Transplant Congress
Replicative Senescence and Arteriosclerosis After Kidney Transplantation.
K. De Vusser,¹ D. Martens,² E. Lerut,³ D. Kuypers,¹ T. Nawrot,² M. Naesens.¹
¹Department of Nephrology and Renal Transplantation, UZ Leuven, Leuven, Belgium; ²Department of Imaging and Pathology, KULeuven, Leuven, Belgium; ³Centre for Environmental Sciences, U Hasselt, Hasselt, Belgium.
BackgroundReplicative senescence is associated with telomere shortening. In native kidneys, obtained prior to transplantation, we recently described and validated a significant association between shorter intrarenal…
2016 American Transplant Congress
Defining Frailty in Liver Transplant Recipients.
L. Louwers,¹ K. Eid,¹ J. Plescia,¹ N. Presser,¹ J. Muntean,¹ M. Kattan,² K. Chagrin,² C. Miller,¹ D. Kelly.¹
¹Surgery, Cleveland Clinic, Cleveland, OH; ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
PURPOSETo define frailty in the liver transplant (OLT) population to optimize care and assist in predicting post OLT outcomes.METHODSAll adult primary OLT patients from 01/2010…
2016 American Transplant Congress
Induction Agent Use and Outcomes in Older KT Recipients: Patient and Center Level Associations.
M. McAdams-DeMarco, Q. Huang, X. Luo, B. Orandi, S. Dorry.
Johns Hopkins, Baltimore.
Background: Clinical trials of induction agents typically exclude older recipients, so our practice in older recipients is extrapolated from this. Older adults are different, so…
2016 American Transplant Congress
C1-Inhibitor Abrogated Ischemia/Reperfusion (I/R) Induced Inflammaging by Inhibiting Senescence-Associated Secretory Phenotype (SASP) in Tubular Epithelial Cells (TEC).
G. Castellano,¹ R. Franzin,¹ A. Stasi,¹ C. Divella,¹ M. Gigante,¹ S. Simone,¹ A. Intini,¹ A. Picerno,¹ P. Pontrelli,¹ A. Crovace,¹ M. Battaglia,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; ²Pharming Technologies, Leiden, Netherlands; ³Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Inflammaging is a pathogenic process usually associated with chronic kidney disease such as diabetic nephropathy where TEC cells have a diminished regenerative potential and develop…
2016 American Transplant Congress
The Effect of Families on Organ Donation Among Native Americans.
T. Bongiovanni,^1,3 J. Rawlings,² J. Trompeta.¹
¹Dept of Surgery, UCSF, San Francisco, CA; ²CT Native American Tribal Council, New Haven, CT; ³Robert Wood Johnson Foundation CSP, Yale University School of Medicine, New Haven, CT.
Background: Prevalence of end-stage renal disease is 3.5 times greater among the >2.5 million Native Americans (NAs) in the US than in Caucasians, due to…
2016 American Transplant Congress
The Long and Short of Old and Cold on Renal Allograft Outcomes.
A. Naik,¹ D. Luan,¹ K. Lentine,² P. Rao,¹ A. Sakhuja,¹ Y. Huang,¹ M. Samaniego,¹ S. Norman,¹ A. Ojo,¹ D. Cibrik.¹
¹University of Michigan, Ann Arbor; ²Saint Louis University, St. Louis.
Introduction: Donor age and cold ischemia times (CIT) have been shown to have independent and varying degrees of impact on short and long term risk…
2016 American Transplant Congress
Factors Associated with Acute Rejections in Kidney Transplant Recipients: Time for HLA-DR Matching in Elderly Recipients?
D. Khadzhynov, F. Halleck, L. Lehner, M. Duerrr, A. Kleinsteuber, D. Schmidt, K. Budde, O. Staeck.
Nephrology, Charite Universitaetsmedizin, Berlin, Germany.
Background. Within the Eurotransplant Senior Allocation Program (ESP) HLA-matching is neglected,potentially causing inferior outcomes. There is a lack of data analysing the long-term immunologic outcomes…
2016 American Transplant Congress
Age Adapted Immunosuppression for Elderly Kidney Allograft Recipients: Balancing Risks for Cancer versus Rejection.
F. Jackson-Spence,¹ H. Gillott,¹ S. Tahir,¹ F. Evison,² J. Nath,³ A. Sharif.³
¹University of Birmingham Medical School, Birmingham, United Kingdom; ²Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom; ³Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Introduction Cancer is a growing cause of morbidity and mortality after kidney transplantation, driven by immunosuppression. Age is one of the strongest risk factors for…
2016 American Transplant Congress
The Effect of Donor Age on Acute Rejection Age – The Clinical Impact of Donor Immuno-Senescence in the Modern Immunosuppressive Era.
U. Khalid, P. Donato, L. Szabo, R. Chavez, E. Ablorsu, A. Asderakis.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom.
Experimental work has shown that donor age may alter the immune response of the recipient so that older donor grafts elicit a stronger response in…
2016 American Transplant Congress
Dendritic Cells and Damage-Associated Molecular Patterns in Aging.
M. Seyda, H. Li, G. Liu, M. Quante, H. Uehara, J. Schuitenmaker, A. Elkhal, S. Tullius.
Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Boston.
Recently, it has been shown that Dendritic Cells (DCs) of old organs accelerate graft rejection by orchestrating IL-17A-mediated T cell responses. Moreover, cell-free DNA has…