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Articles tagged "Age factors"

  • 2016 American Transplant Congress

    The Effect of Families on Organ Donation Among Native Americans.

    T. Bongiovanni,1,3 J. Rawlings,2 J. Trompeta.1

    1Dept of Surgery, UCSF, San Francisco, CA; 2CT Native American Tribal Council, New Haven, CT; 3Robert Wood Johnson Foundation CSP, Yale University School of Medicine, New Haven, CT.

    Background: Prevalence of end-stage renal disease is 3.5 times greater among the >2.5 million Native Americans (NAs) in the US than in Caucasians, due to…
  • 2016 American Transplant Congress

    The Long and Short of Old and Cold on Renal Allograft Outcomes.

    A. Naik,1 D. Luan,1 K. Lentine,2 P. Rao,1 A. Sakhuja,1 Y. Huang,1 M. Samaniego,1 S. Norman,1 A. Ojo,1 D. Cibrik.1

    1University of Michigan, Ann Arbor; 2Saint Louis University, St. Louis.

    Introduction: Donor age and cold ischemia times (CIT) have been shown to have independent and varying degrees of impact on short and long term risk…
  • 2016 American Transplant Congress

    Factors Associated with Acute Rejections in Kidney Transplant Recipients: Time for HLA-DR Matching in Elderly Recipients?

    D. Khadzhynov, F. Halleck, L. Lehner, M. Duerrr, A. Kleinsteuber, D. Schmidt, K. Budde, O. Staeck.

    Nephrology, Charite Universitaetsmedizin, Berlin, Germany.

    Background. Within the Eurotransplant Senior Allocation Program (ESP) HLA-matching is neglected,potentially causing inferior outcomes. There is a lack of data analysing the long-term immunologic outcomes…
  • 2016 American Transplant Congress

    Age Adapted Immunosuppression for Elderly Kidney Allograft Recipients: Balancing Risks for Cancer versus Rejection.

    F. Jackson-Spence,1 H. Gillott,1 S. Tahir,1 F. Evison,2 J. Nath,3 A. Sharif.3

    1University of Birmingham Medical School, Birmingham, United Kingdom; 2Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom; 3Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

    Introduction Cancer is a growing cause of morbidity and mortality after kidney transplantation, driven by immunosuppression. Age is one of the strongest risk factors for…
  • 2016 American Transplant Congress

    The Effect of Donor Age on Acute Rejection Age – The Clinical Impact of Donor Immuno-Senescence in the Modern Immunosuppressive Era.

    U. Khalid, P. Donato, L. Szabo, R. Chavez, E. Ablorsu, A. Asderakis.

    Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom.

    Experimental work has shown that donor age may alter the immune response of the recipient so that older donor grafts elicit a stronger response in…
  • 2016 American Transplant Congress

    Dendritic Cells and Damage-Associated Molecular Patterns in Aging.

    M. Seyda, H. Li, G. Liu, M. Quante, H. Uehara, J. Schuitenmaker, A. Elkhal, S. Tullius.

    Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Boston.

    Recently, it has been shown that Dendritic Cells (DCs) of old organs accelerate graft rejection by orchestrating IL-17A-mediated T cell responses. Moreover, cell-free DNA has…
  • 2016 American Transplant Congress

    Acute Rejection Profoundly Impacts Graft Survival in Young but Not in Old Kidney Transplant Recipients.

    C. Denecke,1,3 M. Biebl,1,3 J. Fritz,2 A. Brandl,1,4 S. Weiss,1,4 T. Dziodzio,1,3 F. Aigner,1,3 R. Sucher,1,3 C. Bösmüller,1 J. Pratschke,1,3,4 R. Öllinger.1,3

    1Visceral, Transplantation and Thoracic Surgery, Medical University, Innsbruck, Austria; 2Medical Statistics, Informatics and Health Economics, Medical University, Innsbruck, Austria; 3General, Visceral and Transplantation Surgery, Charité Universitätsmedizin, Campus Virchow, Berlin, Germany; 4General, Visceral, Vascular and Thoracic Surgery, Charite Universitätsmedizin, Campus Mitte, Berlin, Germany.

    Background: The proportion of marginal grafts and elderly recipients awaiting kidney transplantation is ever increasing. The correlation of age with DGF and acute rejection determines…
  • 2016 American Transplant Congress

    Clinical Prediction Tool to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation.

    L.-X. Chen,1 M. Josephson,1 N. Stankus,1 K. Campbell,1 D. Hedeker,2 M. Saunders.1

    1Department of Medicine, University of Chicago, Chicago, IL; 2Department of Public Health Sciences, University of Chicago, Chicago, IL.

    Background: Adults over 70 years old are the fastest growing segment of the end stage renal disease (ESRD) population. Due to substantial variation in co-morbidities…
  • 2016 American Transplant Congress

    End Stage Renal Disease Patients Have a Skewed T Cell Receptor Vbeta Repertoire.

    L. Huang,1 A. Langerak,2 I. Wolvers - Tettero,2 R. Meijers,1 C. Baan,1 N. Litjens,1 M. Betjes.1

    1Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; 2Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.

    IntroductionEnd stage renal disease (ESRD) is associated with a defective T-cell mediated immunity, resembling premature T-cell ageing. A diverse T-cell receptor Vbeta (TCR Vβ) repertoire…
  • 2016 American Transplant Congress

    Ageing as a Barrier to Transplant Tolerance.

    J. Kim, R. Stott, H. Deirawan, L. Kojima, L. Washburn, G. Zhao, H. Yeh, J. Markmann.

    Surgery/Transplant, Massachusetts General Hospital, Harvard Medical, Boston, MA.

    We recently demonstrated that ageing also impedes development of transplantation tolerance. Unlike their young counterparts (8-12 weeks of age) aged male recipients (greater than 12…
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