Articles tagged "Age factors"

2019 American Transplant Congress
Long-Term Outcomes of Older Kidney-Transplant Recipients: A Single-Center Experience
S. Sultan, M. Aull, M. Lubetzky, A. Watkins, S. Kapur
Weill Cornell Medical College, New York, NY
*Purpose: Given the aging population of patients with ESRD, and the high rates of associated mortality, at our center we perform an individualized risk assessment…
2019 American Transplant Congress
Infectious Complications in Kidney Transplant Recipients Age 65 and Older
L. E. Liriano-Ward¹, M. Barbachan e Silva², Y. Azzi¹, M. Ajaimy¹, A. Cambell¹, J. Graham¹, J. Rocca¹, C. Pynadath¹, G. Nair¹, O. Andacoglu¹, S. Greenstein¹, P. Ó Broin², E. Akalin¹
¹Transplant, Einstein/Montefiore Medical Center, Bronx, NY, ²School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway, Galway, Ireland
*Purpose: Kidney transplant recipients age 65 years and older are at higher risk for development of infections. We aimed to investigate the incidence of both…
2019 American Transplant Congress
The Power of Young Donor Liver; Elixir of Life for Sick Liver Transplant Recipient
J. Kusakabe¹, J. McVey², D. J. Firl², M. Fujiki², F. N. Aucejo², C. Quintini², K. Hashimoto², K. Sasaki²
¹Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Cleveland Clinic Foundation, Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Young donor organs are known to have significant prognostic benefits in liver transplantation (LT). However, details of short- and long-term prognostic benefits of young…
2019 American Transplant Congress
Poor Outcomes in Kidney Transplant Candidates & Recipients with History of Falls
N. Chu¹, H. Ying¹, Z. Shi¹, C. Haugen¹, S. Norman², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins, Baltimore, MD, ²Michigan Medical Center, Ann Arbor, MI
*Purpose: In patients with ESRD, serious fall injuries (e.g. fractures) are associated with decreased chance of listing or transplantation. It is likely that KT candidates…
2019 American Transplant Congress
Combined Ischemic and Rapamycin Preconditioning Alleviated Liver Ischemia and Reperfusion Injury by Restoring Autophagy in Old Mice
Z. Rao, X. Pan, W. Zhong, Z. Ding, H. Zhou, C. Liu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the…
2019 American Transplant Congress
Outcomes of Liver Transplantation for Hepatocellular Carcinoma in Septuagenarians
M. Najjar¹, K. Bruestle¹, P. Jiang¹, E. Lieberman¹, R. Hwang¹, A. Mathur¹, E. C. Verna¹, A. Griesemer¹, B. Samstein², T. Kato¹, Y. M. Saenger¹, K. J. Halazun², J. C. Emond¹
¹Columbia University Medical Center, New York, NY, ²Weill Cornell Medicine, New York, NY
*Purpose: The impact of advanced age on liver transplantation (LT) for hepatocellular carcinoma (HCC) has not been well studied. We sought to compare post-OLT survival…
2019 American Transplant Congress
Senescent Cell Clearance with Senolytic Drugs Improves Cardiac Allograft Survival by Targeting mt-DNA Mediated Immune Responses
J. Iske¹, M. Koichiro¹, M. Seyda¹, T. Heinbokel¹, Y. Nian¹, R. Maenosono¹, H. Azuma¹, C. Falk², T. Tchokonia³, J. Kirkland³, A. Elkhal¹, S. Tullius¹
¹Transplant Surgery, Brigham and Women's Hospital, Boston, MA, ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ³Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN
*Purpose: Older organs represent an underutilized potential. We dissected alloimmune responses when transplanting older organs and tested if the depletion of senescent cells in older…
2019 American Transplant Congress
Damage-Associated Molecular Pattern Release and Toll-Like Receptor Activation during Cold Storage and Ex Vivo Reperfusion of Old Rat Livers
U. Scheuermann, E. R. Seyferth, M. Zhu, M. Song, J. Yerxa, R. P. Davis, W. Parker, M. Hartwig, J. Kwun, J. Lee, A. S. Barbas
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Donor age is one of the most important predictive factors of graft outcome in liver transplantation. The aim of this study was to investigate…
2019 American Transplant Congress
Fatal Graft versus Host Disease in Liver Transplantation. An Analysis of UNOS Registry
S. Nagai¹, A. Yoshida¹, R. Salgia², M. Abouljoud¹, D. Moonka²
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI, ²Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: Graft-versus-host disease (GVHD) after liver transplant is a rare complication. This study aimed to analyze the UNOS registry to identify risk factors for fatal…
2019 American Transplant Congress
The Outcomes after an Infection in Older Liver Transplant Recipients is Comparable to Younger Adults
J. Garcia-Diaz¹, M. Kerkelis², T. Shah³, M. Tucker⁴, M. Gastanaduy⁵, J. Woo¹, M. Ponder¹, M. Malinis⁶, M. Malinis⁶
¹Infectious Diseases, Ochsner Medical Center, New Orleans, LA, ²University of Queensland/Ochsner Clinical School, New Orleans, LA, ³Internal Medicine, St. Joseph Hospital, Denver, CO, ⁴Internal Medicine, Yale School of Medicine, New Haven, CT, ⁵Center for Outcomes and Health Services Research, Ochsner Medical Center, New Orleans, LA, ⁶Infectious Diseases, Yale School of Medicine, New Haven, CT
*Purpose: Solid organ transplantation is being increasingly offered to older patients with concurrent chronic medical conditions such as cardiovascular, cerebrovascular, and renal disease. Risk of…