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Articles tagged "Adverse effects"

  • 2018 American Transplant Congress

    Belatacept and Tacrolimus Corticosteroid-Free Regimens Lead to Elevated Mycophenolic Acid Exposure at 1 and 3 Months after Kidney Transplantation

    A. Dao, S. Tremblay, A. Shields, A. Loethen, B. Abu Jawdeh, T. Diwan, A. Govil, E. Woodle, R. Alloway.

    UCincinnati, Cincinnati.

    Mycophenolate mofetil (MMF) is generally administered as a fixed dose. Studies have shown a relationship between MPA exposure (MPAAUC) but no data evaluates this relationship…
  • 2018 American Transplant Congress

    Efficacy and Safety of a Single-Dose Rituximab for Prevention of Focal Segmental Glomerulosclerosis Recurrence after Kidney Transplant

    Y. Lu,1 J. Lyons,2 S. Tischer,2 K. Woodside,3 J. Park.2

    1Transplant Nephrology, University of Michigan, Ann Arbor, MI; 2Transplant Pharmacy, University of Michigan, Ann Arbor, MI; 3Transplant Surgery, University of Michigan, Ann Arbor, MI.

    Background: For patients with end stage renal disease (ESRD) due to primary focal segmental glomerulosclerosis (FSGS), there is a significantly increased risk for disease recurrence…
  • 2018 American Transplant Congress

    The Infusion with a Difference: Patient Experiences with Belatacept

    H. Murad, D. Malhotra, E. Cohen, W. Asch.

    Yale University, New Haven, CT.

    Introduction: The results of the BENEFIT trial led to the FDA approval of the novel anti-rejection agent belatacept (bela) in 2011. In addition to its…
  • 2017 American Transplant Congress

    Single-Center Initial Experience in Treating Chronic Hepatitis C in Kidney Transplant Recipients.

    G. Meinerz, C. da Silva, R. Bruno, E. Keitel, V. Garcia.

    Nephrology and Kidney Transplant Department, ISCMPA, Porto Alegre, RS, Brazil

    Chronic hepatitis C (HCV) infection is a prevalent condition in end-stage renal disease and presents an important clinical challenge in kidney transplant recipients (KTR). Interferon-based…
  • 2017 American Transplant Congress

    Alemtuzumab Induction Is Safe, and Permits the Avoidance of Steroids in the Majority of Renal Transplant Recipients.

    A. Seitz,1 M. Robb,2 N. Ahmad,1 A. McLean,3 D. Taube,3 R. Johnson,2 R. Baker.1

    1Renal Unit, St James's Hospital, Leeds, United Kingdom; 2Organ Donation and Transplantation Studies, NHS Blood and Transplant, Bristol, United Kingdom; 3West London Renal and Transplant, Hammersmith Hospital, London, United Kingdom

    IntroductionThe introduction of alemtuzumab into routine clinical use has been hindered by safety concerns surrounding its prolonged effect on the lymphoid compartment. Here we report…
  • 2017 American Transplant Congress

    Systemic Immunosuppression in the Setting of Ocular Surface Stem Cell Transplantation.

    A. Govil,1 A. Cheung,2 E. Sarnicola,2 E. Holland.2

    1University of Cincinnati, Cincinnati, OH; 2Cincinnati Eye Institute, Cincinnati, OH

    Purpose: To evaluate the success, tolerability, and side effects of systemic immunosuppression (SI) in patients undergoing ocular surface stem cell transplantation (OSST) under the SI…
  • 2017 American Transplant Congress

    Improvement of Cyclosporine A Dosing Strategy to Enhance Medication Adherence.

    M. Barten,1 E. Harmel,1 M. Goldmann,1 F. Wagner,1 H. Reichenspurner,1 M. Rybczynski.2

    1Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; 2General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany

    Background: It is known that the number of daily pills is crucial for medical adherence of patients after heart transplantation (HTx). For cyclosporine A (CsA)…
  • 2017 American Transplant Congress

    This is Why We Can't Have Nice Things- Real World Experience with Everolimus in Livers.

    C. Perez,1 J. Fleming,1 M. Sell,1 B. O'Brien,1 A. Rogers,1 I. Lee,1 C. Mardis,1 A. Mardis,1 N. Patel,1 H. Meadows,1 N. Pilch,2 K. Chavin,2 D. Dubay,2 D. Taber.2

    1Pharmacy, Medical University of South Carolina, Chareleston, SC; 2Surgery, Medical University of South Carolina, Charleston, SC

    Purpose: To determine if discontinuation rates of everolimus (RAD) in clinical practice is higher than the 30% demonstrated in trials.Methods: This was a retrospective cohort…
  • 2017 American Transplant Congress

    An Investigation of Biopsy-Proven De Novo Autoimmune Hepatitis After Hepatitis C Clearance with Direct Acting Antivirals in Liver Transplant Patients.

    R. Sigireddi, J. Moffett, M. Kueht, R. Ackah, A. Rana, C. O'Mahony, J. Goss, S. Dhingra, S. Khaderi.

    Department of Abdominal Transplantation, Baylor College of Medicine, Houston, TX

    Direct acting antivirals (DAAs) for hepatitis C virus (HCV) have been widely prescribed to post-liver transplant patients for HCV clearance and are believed to be…
  • 2017 American Transplant Congress

    De Novo Low-Dose Sirolimus versus Mycophenolate Mofetil in Combination with Extended-Release Tacrolimus in Kidney Transplant Recipients.

    J. Lee,1 K. Huh,1 J. Ha,2 C.-K. Oh,3 M. Ju,4 C.-D. Kim,5 H. Cho,6 C. Jung,7 B. Lim,8 Y. Kim.1

    1Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; 2Surgery, Seoul National University Hospital, Seoul, Republic of Korea; 3Surgery, Ajou University Hospital, Suwon, Republic of Korea; 4Surgery, Gangnam Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea; 5Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea; 6Surgery, Ulsan University Hospital, Ulsan, Republic of Korea; 7Surgery, Korea University Anam Hospital, Seoul, Republic of Korea; 8Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea

    Previous studies reported that tacrolimus (TAC) with high-dose sirolimus (SRL) was associated with worse outcomes in kidney transplantation, compared to TAC with mycophenolate mofetil (MMF.).…
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