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Articles tagged "Adhesion molecules"

  • 2018 American Transplant Congress

    CD4 T Cells Require Both S1PR1 and S1PR4 for Afferent Lymphatic Migration

    Y. Xiong,1 W. Piao,1 C. Brinkman,1 L. Li,1 J. Kulinski,2 A. Olivera,2 A. Cartier,3 T. Hla,3 S. Schwab,4 K. Hippen,5 B. Blazar,5 J. Bromberg.1

    1UMB, MD; 2NIH, MD; 3Boston Children's Hospital, MA; 4NYU, NY; 5U. Minnesota, MN.

    Introduction: Sphingosine 1-phospate (S1P) receptor 1 (S1PR1) drives T cell migration from thymus into blood, and lymph nodes (LN) into efferent lymphatics. Whether S1PR1 and…
  • 2018 American Transplant Congress

    Lymphatic Endothelium Requires S1PR2 for T Cell Transendothelial Migration

    Y. Xiong,1 W. Piao,1 C. Brinkman,1 L. Li,1 J. Kulinski,2 A. Olivera,2 A. Cartier,3 T. Hla,3 S. Schwab,4 K. Hippen,5 B. Blazar,5 J. Bromberg.1

    1UMB, MD; 2NIH, MD; 3Boston Children's Hospital, MA; 4NYU, NY; 5U. Minnesota, MN.

    Introduction: Sphingosine 1-phosphate (S1P) receptors 1 (S1PR1) and S1PR2 are highly expressed by lymphatic endothelial cells (LEC), while T cells express S1PR1 and S1PR4. S1P…
  • 2018 American Transplant Congress

    Involvement of PD-L1 Upregulation in Anti-A/B Antibody-Induced Graft Accommodation: Reduction of CD4 T Cell Allo-Response against Graft HLA Class II DR

    K. Iwasaki,1 Y. Miwa,1 H. Hamana,3 H. Kishi,3 A. Muraguchi,3 K. Uchida,1 T. Kobayashi.2

    1Kidney Disease and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 2Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 3Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

    [Background] Antibodies against transplanted organs cause complement-independent graft injury, but there remain many unknown aspects of its mechanism, in particular its effect on allo-response to…
  • 2017 American Transplant Congress

    Uptake of Extracellular Mitochondria Activates Human Endothelial Cells That Stimulate Alloreactive Effector T Cell Responses.

    T. Brennan,1 F. Feng,1 L. Lin,1 M. Song,1 Q.-J. Li,2 A. Kirk,1,2 H. Xu.1

    1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC

    Introduction: Vascular endothelial cells (VECs), the initial barrier between host immunity and donor allograft tissue, play a critical role in allograft rejection. We investigated the…
  • 2017 American Transplant Congress

    The Treg/Th17 Axis: A Dynamic Balance Regulated by Stromal Laminins.

    T. Simon, J. Bromberg.

    University of Maryland, Baltimore

    Background: Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively…
  • 2017 American Transplant Congress

    Binding of Human Neutrophils to Activated Porcine Endothelium Is Mediated by E-Selectin.

    C. Laird,1 B. French,1 L. Burdorf,1 X. Cheng,1 W. Fogler,2 J. Magnani,2 C. Phelps,3 D. Ayares,3 A. Azimzadeh,1 R. Pierson.1

    1University of Maryland SOM, Baltimore; 2GlycoMimetics, Inc, Rockville; 3Revivicor, Inc, Blacksburg

    Purpose: Shortage of transplantable human organs motivates research into alternatives, including xenotransplantation. When porcine lungs are perfused with human blood, a majority of human neutrophils…
  • 2016 American Transplant Congress

    A Unique In Vitro Migration Model for Leukocyte Trans-Lymphatic Endothelial Migration.

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.

    Trans-endothelial migration (TEM) is an essential process for leukocyte circulation. While much is known about lymphocyte blood to tissue migration, far less is known about…
  • 2016 American Transplant Congress

    Belatacept Immunotherapy Is Not Augmented by Blockade of Activated LFA-1 in a Nonhuman Primate Renal Transplant Model.

    K. Samy,1 M. Mulvihill,1 B. Collins,1 D. Lo,2 M. Song,1 F. Leopardi,1 A. Kirk.1,2

    1Department of Surgery, Duke University Medical Center, Durham, NC; 2Emory University, Atlanta, GA.

    Purpose: Belatacept specifically targets de novo alloimmune responses without off target side effects. However, resistant alloreactive memory T cells have complicated its use. LFA-1 therapy…
  • 2016 American Transplant Congress

    Acute Rejection in Non-Human Primates Treated with Belatacept Is Mediated by a Unique CD8 Memory Subset.

    D. Mathews,1 W. Wakwe,1 M. Lowe,1 C. Breeden,1 F. Leopardi,1 A. Farris,1 M. Song,1 E. Strobert,2 J. Jenkins,2 C. Larsen,1 R. Townsend,3 A. Adams.1

    1Emory Transplant Center, Emory University, Atlanta, GA; 2Yerkes National Primate Research Center, Atlanta, GA; 3Bristol Myers-Squibb Pharmaceutical Research Institute, Princeton, NJ.

    Belatacept is a high affinity version of the fusion protein CTLA4-Ig that blocks CD28 mediated T cell costimulation, providing a more targeted/less toxic form of…
  • 2015 American Transplant Congress

    VLA-4 Blockade Inhibits Endogenous Memory CD8 T Cell-Mediated Rejection of Cardiac Allografts

    S. Iida,1 C. Su,1 T. Abe,1 K. Tanabe,2 R. Fairchild.1

    1Immunology, Cleveland Clinic, Cleveland, OH; 2Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Endogenous memory CD8 T cells infiltrate cardiac allografts within 24 hours of reperfusion and are activated to proliferate and produce IFN-γ in response to donor…
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