2022 American Transplant Congress » Tregs and Tolerance

5:30pm-5:40pm

Synergistic Effect of CXCR5⁺CD8⁺ T_Ab-supp Cell Adoptive Cell Therapy and mTOR Inhibition (but Not Calcineurin Inhibition) in Suppressing Alloantibody Following Kidney Transplant in Mice

J. L. Han¹, J. M. Zimmerer¹, Q. Zeng², S. Chaudhari¹, C. K. Breuer², G. L. Bumgardner¹

5:40pm-5:50pm

Alloreactive Regulatory T Cells Release Distinct Subpopulations of Extracellular Vesicles Bearing Immune Regulatory Proteins and the TCR/CD3 Complex Under Antigen Specific Stimulation

B. Schreiber, S. Tripathi, A. Sonawane, M. Blaser, S. Kuraoka, S. Singh, M. Aikawa, E. Aikawa, A. Chandraker

5:50pm-6:00pm

TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival

S. Miura¹, Z. Abady¹, F. Pollok¹, M. Ma¹, K. Kinoshita¹, S. Fogarty², P. Maguire², B. Daugherty², S. Lederman², R. Pierson III¹

6:00pm-6:10pm

Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells

E. Landmann¹, P. Ruiz¹, A. Kurt¹, E. Kodela¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹

6:10pm-6:20pm

A Novel IL-2 Mutein Selectively Expands Regulatory T Cells and Prolongs Skin Graft Survival

O. Efe¹, T. J. Borges¹, R. B. Gassen¹, L. Morena¹, A. Al Jurdi¹, I. T. Lape¹, G. J. Bobcock², J. C. Madsen¹, L. V. Riella¹

6:20pm-6:30pm

TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3⁺ Treg

C. R. Hartigan, D. Liu, S. Laurie, M. L. Ford

6:30pm-6:40pm

Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates

C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, A. Dehnadi, T. Costa, M. Momodu, J. A. Morrissette, D. Muldoon, I. M. Hanekamp, J. S. Allan, G. Benichou, J. C. Madsen

6:40pm-6:50pm

Why Females Have Weaker Tregs Than Males: Inhibitory Effects of Estrogen Receptor Signaling on Foxp3+ Treg Cell Suppressive Function

L. M. Christensen¹, T. Akimova¹, G. Ge², R. Han¹, L. Wang³, C. O'Brien², M. Levine², W. W. Hancock³

6:50pm-7:00pm

Alloreactive Human Regulatory T Cell-Derived Extracellular Vesicles Exhibit Adenosinergic Mediated Suppression and Potential for Infectious Tolerance

B. Schreiber, S. Tripathi, A. Chandraker